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1,162 results
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Sulfonylureas [BOOK]
    National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • The sulfonylureas are a class of agents that lower blood sugar as a result of increasing release of insulin from the pancreas. The sulfonylureas are used for the therapy of mild-to-moderate type 2 diabetes in conjunction with diet, and can be used alone or in combination with metformin, thiazolidinediones or other hypoglycemic agents. The sulfonylureas have been associated with rare cases of idio…
  • Sulfonylurea derivatives and cancer, friend or foe? [Review]
    Eur J Pharmacol 2019; 861:172598Hendriks AM, Schrijnders D, … Landman GWD
  • Type 2 diabetes mellitus (T2DM) is associated with a higher risk of cancer and cancer-related mortality. Increased blood glucose and insulin levels in T2DM patients may be, at least in part, responsible for this effect. Indeed, lowering glucose and/or insulin levels pharmacologically appears to reduce cancer risk and progression, as has been demonstrated for the biguanide metformin in observation…
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