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1,155 results
  • Sulfonylurea derivatives and cancer, friend or foe? [Review]
    Eur J Pharmacol 2019; 861:172598Hendriks AM, Schrijnders D, … Landman GWD
  • Type 2 diabetes mellitus (T2DM) is associated with a higher risk of cancer and cancer-related mortality. Increased blood glucose and insulin levels in T2DM patients may be, at least in part, responsible for this effect. Indeed, lowering glucose and/or insulin levels pharmacologically appears to reduce cancer risk and progression, as has been demonstrated for the biguanide metformin in observation…
  • Clarithromycin and Glipizide Drug-drug Interaction Leading to Refractory Hypoglycemia. [Case Reports]
    Cureus 2019; 11(6):e4800Ruan XC, Tan PY, Tan Y
  • A 70-year-old end-stage renal disease patient was admitted for refractory hypoglycemia secondary to drug-drug interaction between clarithromycin and glipizide. We discussed the mechanism of antimicrobial and sulfonylurea interactions as well as the importance of understanding these interactions in the primary care setting to reduce medication-related hospitalizations.
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