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667 results
  • Methotrexate overdose in clinical practice. [Journal Article]
    Curr Drug Metab 2019Pannu AK
  • CONCLUSIONS: The management should focus on high-quality supportive care, antidotal therapy (folinic acid and carboxypeptidase-G2) and plasma alkalization. In accordance to the dictum "prevention is better than cure", the author emphasizes the role of patient education, regular clinical observation, and laboratory monitoring for prompt recognition and diagnosis of methotrexate overdoing at the earliest stage.
  • Production of "biobetter" variants of glucarpidase with enhanced enzyme activity. [Journal Article]
    Biomed Pharmacother 2019; 112:108725Al-Qahtani AD, Bashraheel SS, … Goda SK
  • Glucarpidase, also known as carboxypeptidase G2, is a Food and Drug Administration-approved enzyme used in targeted cancer strategies such as antibody-directed enzyme prodrug therapy (ADEPT). It is also used in drug detoxification when cancer patients have excessive levels of the anti-cancer agent methotrexate. The application of glucarpidase is limited by its potential immunogenicity and limited…
  • Discovering Putative Protein Targets of Small Molecules: A Study of the p53 Activator Nutlin. [Journal Article]
    J Chem Inf Model 2019; 59(4):1529-1546Nguyen MN, Sen N, … Madhusudhan MS
  • Small molecule drugs bind to a pocket in disease causing target proteins based on complementarity in shape and physicochemical properties. There is a likelihood that other proteins could have binding sites that are structurally similar to the target protein. Binding to these other proteins could alter their activities leading to off target effects of the drug. One such small molecule drug Nutlin …
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