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(glucose polymer)
168,346 results
  • Structural investigation of human dectin-1 receptor; A novel gateway in drug discovery. [Journal Article]
    Pak J Pharm Sci 2019; 32(4):1509-1518Roome T, Rashid Y, … Razzak A
  • Stimulation of C-type lectin domain of human dectin-1 receptor by fungal β-glucans causes conformational changes in its cytoplasmic domain which initiates various cellular responses mediated by downstream signaling components. We aimed to build the three-dimensional structures of the cytoplasmic domain as well as C-type lectin domain of human Dectin-1along with their potential ligands through hom…
  • Nanomaterials derived from fungal sources - is it the new hype? [Journal Article]
    Biomacromolecules 2019Nawawi WMFBW, Jones M, … Bismarck A
  • Greener alternatives to synthetic polymers are constantly being investigated and sought after. Chitin is a natural polysaccharide that gives structural support to crustacean shells, insect exoskeletons, and fungal cell walls. Like cellulose, chitin resides in nanosized structural elements that can be isolated as nanofibers and nanocrystals by various top-down approaches, targeted at disintegratin…
  • Synthesis of β-1,3-glucan mimics by β-1,3-glucan trisaccharyl monomer polymerization. [Journal Article]
    Carbohydr Polym 2020; 227:115105Miyagawa A, Yamamura H
  • β-1,3-Glucans are important as immunostimulating agents in living organisms. The multivalent binding of β-1,3-glucans to dectin-1, a cell surface receptor, activates immunological defenses. To study artificial immunostimulating agents, glycopolymers carrying β-1,3-glucan trisaccharides as artificial ligands were synthesized. The β-1,3-glucan trisaccharide, defined as an active unit of β-1,3-gluca…
  • A hidden battle in the dirt: Soil amoebae interactions with Paracoccidioides spp. [Journal Article]
    PLoS Negl Trop Dis 2019; 13(10):e0007742Albuquerque P, Nicola AM, … Silva-Pereira I
  • Paracoccidioides spp. are thermodimorphic fungi that cause a neglected tropical disease (paracoccidioidomycosis) that is endemic to Latin America. These fungi inhabit the soil, where they live as saprophytes with no need for a mammalian host to complete their life cycle. Despite this, they developed sophisticated virulence attributes allowing them not only to survive in host tissues but also to c…
  • Response-retaliation behaviour in synthetic protocell communities. [Journal Article]
    Angew Chem Int Ed Engl 2019Qiao Y, Li M, … Mann S
  • Two different artificial predation strategies are spatially and temporally coupled to generate a simple tit-for-tat mechanism in a ternary protocell network capable of antagonistic enzyme-mediated interactions. The consortium initially consists of protease-sensitive glucose oxidase-containing proteinosomes (1), non-interacting pH-sensitive polypeptide/mononucleotide coacervate droplets containing…
  • Brexanolone for the treatment of patients with postpartum depression. [Journal Article]
    Drugs Today (Barc) 2019; 55(9):537-544Morrison KE, Cole AB, … Bale TL
  • On March 19, 2019, the United States Food and Drug Administration (FDA) approved Zulresso (brexanolone) for intravenous use for the treatment of postpartum depression (PPD) in adult women. The decision was based on three recent clinical trials following an FDA priority review and breakthrough therapy designation. Brexanolone is now available through a restricted process called the Zulresso Risk E…
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