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6,730 results
  • Intravenous Glibenclamide Reduces Lesional Water Uptake in Large Hemispheric Infarction. [Journal Article]
    Stroke 2019; :STROKEAHA119026036Vorasayan P, Bevers MB, … Kimberly WT
  • Background and Purpose- Prior studies have shown a linear relationship between computed tomography (CT)-derived radiodensity and water uptake, or brain edema, within stroke lesions. To test the hypothesis that intravenous glibenclamide (glyburide; BIIB093) reduces ischemic brain water uptake, we quantified the lesional net water uptake (NWU) on serial CT scans from patients enrolled in the phase …
  • NLRP3 inflammasome inhibitor glyburide expedites diabetic-induced impaired fracture healing. [Journal Article]
    Immunobiology 2019Yang X, Qu C, … Zhan Y
  • Localized inflammation is accompanied by the diabetic-induced fracture. The present study aims to investigate the therapeutic effects of glyburide, an NLRP3 inflammasome inhibitor, in a diabetic-induced fracture model. An animal model of diabetic-induced fracture was established and the mice were administrated with metformin or glyburide for 3 weeks. Quantitative polymerase chain reaction (qPCR) …
  • StatPearls: Glyburide [BOOK]
    StatPearls Publishing: Treasure Island (FL) Hardin Maiah D. MD Jacobs Tibb F. TF University of Louisiana Monroe BOOK
  • Glyburide also referred to as glibenclamide, is a second-generation sulfonylurea approved by the Food and Drug Administration (FDA) for the treatment of type 2 diabetes mellitus. The medication is available as a generic formulation. It is an adjunct therapy along with diet and exercise for the management of diabetes.[1] Treatment with glyburide has been and continues to be successful in sufficien…
  • Sulfonylurea derivatives and cancer, friend or foe? [Review]
    Eur J Pharmacol 2019; 861:172598Hendriks AM, Schrijnders D, … Landman GWD
  • Type 2 diabetes mellitus (T2DM) is associated with a higher risk of cancer and cancer-related mortality. Increased blood glucose and insulin levels in T2DM patients may be, at least in part, responsible for this effect. Indeed, lowering glucose and/or insulin levels pharmacologically appears to reduce cancer risk and progression, as has been demonstrated for the biguanide metformin in observation…
  • Magnetic Resonance Imaging Pilot Study of Intravenous Glyburide in Traumatic Brain Injury. [Journal Article]
    J Neurotrauma 2019Eisenberg HM, Shenton ME, … Hayman EG
  • Pre-clinical studies of traumatic brain injury (TBI) show that glyburide reduces edema and hemorrhagic progression of contusions. We conducted a small Phase II, three-institution, randomized placebo-controlled trial of subjects with TBI to assess the safety and efficacy of intravenous (IV) glyburide. Twenty-eight subjects were randomized and underwent a 72-h infusion of IV glyburide or placebo, b…
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