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6,688 results
  • Pharmacologic Treatment of Diabetes in Pregnancy. [Journal Article]
  • OGObstet Gynecol Surv 2019; 74(5):289-297
  • Bishop KC, Harris BS, … Kuller JA
  • CONCLUSIONS: Insulin is the preferred pharmacologic treatment according to ACOG. However, SMFM has stated that outcomes with metformin are similar, and it may also be considered as first-line therapy. Both agree that the available data show that metformin is safer and superior to glyburide, and glyburide is no longer recommended as a first-line therapy for the treatment of gestational diabetes.
  • Repurposing glyburide as antileishmanial agent to fight against leishmaniasis. [Journal Article]
  • PPProtein Pept Lett 2019 Feb 28
  • Rub A, Shaker K, … Amir K
  • CONCLUSIONS: The results suggest that glyburide binds to LdTrySyn and inhibits its activity that further leads to altered parasite morphology and inhibition of parasite growth. Glyburide may also be used in combination with other anti-leishmanial drugs to potentiate the response of the chemotherapy. Overall this study provides information about combination therapy as well as a single drug treatment for the infected patients suffering from diabetes. This study also provides raw information for further in vivo disease model studies to confirm the hypothesis.
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