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6,212 results
  • Targeting BKCa Channels in Migraine: Rationale and Perspectives. [Journal Article]
    CNS Drugs 2020Al-Karagholi MA, Gram C, … Ashina M
  • Large (big)-conductance calcium-activated potassium (BKCa) channels are expressed in migraine-related structures such as the cranial arteries, trigeminal ganglion and trigeminal spinal nucleus, and they play a substantial role in vascular tonus and neuronal excitability. Using synthetic BKCa channels openers was associated with headache as a frequent adverse effect in healthy volunteers. Addition…
  • Design of novel tacrolimus formulations with chemically synthesized oils for oral lymphatic delivery. [Journal Article]
    Drug Dev Ind Pharm 2020; 46(2):219-226Yoshida T, Sako K, Kondo H
  • High consumption of oil formulations has been reported to reduce the blood exposure of drugs like tacrolimus. Consumption of oil formulations has also been shown to inhibit T-cell production of interleukin-2 (IL-2) compared to solid dispersion formulations (SDFs). However, a large amount of oil causes gastrointestinal side effects such as diarrhea and low compliance. Here, we investigated the fea…
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