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900,913 results
  • Antiphospholipid antibodies in patients with COVID-19: a relevant observation? [Journal Article]
    J Thromb Haemost. 2020 Jul 03 [Online ahead of print]Devreese KMJ, Linskens EA, … Peperstraete H
  • CONCLUSIONS: Our observations support the frequent single LAC positivity during (acute phase) observed in COVID-19 infection, however not clearly related to thrombotic complications. Triple aPL positivity and high aCL/aβ2GPI titers are rare. Repeat testing suggests aPL to be mostly transient. Further studies and international registration of aPL should improve understanding the role of aPL in thrombotic COVID-19 patients.
  • The potential role of antibodies against minor blood group antigens in renal transplantation. [Review]
    Transpl Int. 2020 Jul 03 [Online ahead of print]Holt SG, Kotagiri P, … Masterson R
  • Blood group antigens are red-blood cell (RBC) surface markers comprising specific carbohydrate moieties attached to the glycolipids and glycoproteins within the membrane. In addition to the major ABO blood group antigens, at least 35 minor blood group antigens have been defined to date. These antigens have immunogenic potential and may cause a transfusion reaction. There is evidence for renal exp…
  • Epitope based peptide vaccine against SARS-COV2: an immune-informatics approach. [Journal Article]
    J Biomol Struct Dyn. 2020 Jul 03 [Online ahead of print]Bhatnager R, Bhasin M, … Dang AS
  • World is witnessing exponential growth of SARS-CoV2 and fatal outcomes of COVID 19 has proved its pandemic potential already by claiming more than 3 lakhs deaths globally. If not controlled, this ongoing pandemic can cause irreparable socio-economic and psychological impact worldwide. Therefore a safe and effective vaccine against COVID 19 is exigent. Recent advances in immunoinformatics approach…
  • Bioinformatic Identification of Plant Hydroxyproline-Rich Glycoproteins. [Journal Article]
    Methods Mol Biol. 2020; 2149:463-481.Liu X, McKenna S, … Showalter AM
  • Hydroxyproline-rich glycoproteins (HRGPs) are a superfamily of plant cell wall proteins that function in diverse aspects of plant growth and development. This superfamily consists of three members: arabinogalactan-proteins (AGPs), extensins (EXTs), and proline-rich proteins (PRPs). Hybrid and chimeric HRGPs also exist. A bioinformatic software program, BIO OHIO 2.0, was developed to expedite the …
  • A candidate multi-epitope vaccine against SARS-CoV-2. [Journal Article]
    Sci Rep. 2020 Jul 02; 10(1):10895.Kar T, Narsaria U, … Srivastava AP
  • In the past two decades, 7 coronaviruses have infected the human population, with two major outbreaks caused by SARS-CoV and MERS-CoV in the year 2002 and 2012, respectively. Currently, the entire world is facing a pandemic of another coronavirus, SARS-CoV-2, with a high fatality rate. The spike glycoprotein of SARS-CoV-2 mediates entry of virus into the host cell and is one of the most important…
  • Atypical MOG antibody disease presenting with typical multiple sclerosis lesions. [Journal Article]
    Mult Scler Relat Disord. 2020 Jun 26; 44:102342.Dolbec K, Chalkley J, Sudhakar P
  • Myelin oligodendrocyte glycoprotein (MOG) antibody disease is an autoimmune disease of the central nervous system associated with a serological antibody against MOG, a glycoprotein expressed on the outer membrane of myelin. It is solely found within the central nervous system in the brain, optic nerves and spinal cord. MOG antibody disease falls within the neuromyelitis optica spectrum disorders …
  • Stimulation with FITC-labeled antigens confers B cells with regulatory properties. [Journal Article]
    Cell Immunol. 2020 Jun 12; 355:104151.Planchais C, Rayes J, … Lacroix-Desmazes S
  • B cells with regulatory properties (Bregs) were identified in human and in mice among different B-cell subsets. Their regulatory properties rely mainly on the production of anti-inflammatory cytokines, in particular IL10, IL-35 and TGFβ, and were extensively studied in mouse models of autoimmune and inflammatory diseases. However, the exact nature of the stimulatory signals conferring regulatory …
  • Mechanobiologically induced bone-like nodules: Matrix characterization from micro to nanoscale. [Journal Article]
    Nanomedicine. 2020 Jun 29 [Online ahead of print]Rammal H, Dubus M, … Kerdjoudj H
  • In bone tissue engineering, stem cells are known to form inhomogeneous bone-like nodules on a micrometric scale. Herein, micro- and nano-infrared (IR) micro-spectroscopies were used to decipher the chemical composition of the bone-like nodule. Histological and immunohistochemical analysesanalyzes revealed a cohesive tissue with bone-markers positive cells surrounded by dense mineralized type-I co…
  • Characterizations of SARS-CoV-2 mutational profile, spike protein stability and viral transmission. [Journal Article]
    Infect Genet Evol. 2020 Jun 29 [Online ahead of print]Laha S, Chakraborty J, … Chatterjee R
  • The recent pandemic of SARS-CoV-2 infection has affected more than 3.0 million people worldwide with more than 200 thousand reported deaths. The SARS-CoV-2 genome has the capability of gaining rapid mutations as the virus spreads. Whole-genome sequencing data offers a wide range of opportunities to study mutation dynamics. The advantage of an increasing amount of whole-genome sequence data of SAR…
  • Agrin-Mediated Cardiac Regeneration: Some Open Questions. [Journal Article]
    Front Bioeng Biotechnol. 2020; 8:594.Bigotti MG, Skeffington KL, … Brancaccio A
  • After cardiac injury, the mammalian adult heart has a very limited capacity to regenerate, due to the inability of fully differentiated cardiomyocytes (CMs) to efficiently proliferate. This has been directly linked to the extracellular matrix (ECM) surrounding and connecting cardiomyocytes, as its increasing rigidity during heart maturation has a crucial impact over the proliferative capacity of …
  • Recent Progress in Chemo-Enzymatic Methods for the Synthesis of N-Glycans. [Review]
    Front Chem. 2020; 8:513.Chao Q, Ding Y, … Gao XD
  • Asparagine (N)-linked glycosylation is one of the most common co- and post-translational modifications of both intra- and extracellularly distributing proteins, which directly affects their biological functions, such as protein folding, stability and intercellular traffic. Production of the structural well-defined homogeneous N-glycans contributes to comprehensive investigation of their biologica…
  • Discovery of Small Molecule Inhibitors Targeting the Sonic Hedgehog. [Journal Article]
    Front Chem. 2020; 8:498.Yun T, Wang J, … Liu Y
  • The aberrant activation of hedgehog (Hh) signaling pathway is closely related to human diseases. The upstream protein, N-terminal product of sonic hedgehog (ShhN) is overexpressed in many cancers and considered as a promising antitumor target. Inhibitors that bind to ShhN and break its interaction with the 12-transmembrane glycoprotein patched (Ptch) protein are highly wanted to tune down the abn…
  • Molecular identification of Cryptosporidium spp. in alpacas (Vicugna pacos) in China. [Journal Article]
    Int J Parasitol Parasites Wildl. 2020 Aug; 12:181-184.Zhang Q, Li J, … Qi M
  • Cryptosporidium is a ubiquitous protozoan in human and animals. To investigate the genetic diversity of Cryptosporidium spp. in alpaca (Vicugna pacos) in China, 484 fecal samples from alpacas were collected at nine sites, and Cryptosporidium spp. were screened with PCR amplification of the small subunit ribosome RNA (SSU rRNA) locus. Cryptosporidium spp. infected 2.9% (14/484) of the alpacas. Of …
  • In Vitro Lymphocyte Functions in Undernourished Children With Sickle Cell Anemia. [Journal Article]
    Ochsner J. 2020 Summer; 20(2):151-160.Kuvibidila SR, Gardner R, … Warrier RP
  • Background: Children with sickle cell disease (SCD) often suffer from growth deficits and impaired immunity. However, the association between mild to moderate malnutrition and in vitro lymphocyte function has not been well studied. The goal of this study was to investigate the effects of undernutrition on lymphocyte functions in children with SCD. Methods: Weight; height; plasma concentrations …
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