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35,792 results
  • Optical coherence tomography angiography analysis of fabry disease. [Journal Article]
    Int Ophthalmol. 2020 Jun 30 [Online ahead of print]Cakmak AI, Atalay E, … Turgut FH
  • CONCLUSIONS: Decreased VD and an enlarged foveal avascular area suggest possible changes in the retinal microvasculature of patients with FD. OCT-A can serve as a useful, noninvasive, quantitative tool for diagnosing FD and monitoring its progression.
  • The Roles of Glycans in Bladder Cancer. [Review]
    Front Oncol. 2020; 10:957.Jian Y, Xu Z, … Wang S
  • Bladder cancer is one of the most common malignant tumors of the urogenital system with high morbidity and mortality worldwide. Early diagnosis and personalized treatment are the keys to successful bladder cancer treatment. Due to high postoperative recurrence rates and poor prognosis, it is urgent to find suitable therapeutic targets and biomarkers. Glycans are one of the four biological macromo…
  • Influence of glycosphingolipids on cancer cell energy metabolism. [Review]
    Prog Lipid Res. 2020 Jun 24; 79:101050.Schömel N, Geisslinger G, Wegner MS
  • A growing number of studies describe a connection between glycosphingolipids (GSLs) and glutamine metabolism, glucose metabolism and mitochondrial dysfunction in cancer cells. Since deregulated cell energy metabolism is one of cancer cells hallmarks, investigating this connection is an important step in the development of anti-cancer therapies. GSL species are often aberrantly regulated in human …
  • Organisation of Gangliosides into Membrane Nanodomains. [Review]
    FEBS Lett. 2020 Jun 26 [Online ahead of print]Sarmento MJ, Ricardo JC, … Šachl R
  • Gangliosides are glycosphingolipids consisting of a ceramide base and a bulky sugar chain that contains one or more sialic acids. This unique structure endows gangliosides with a strong tendency to self-aggregate in solution, as well as in cellular membranes, where they can form nanoscopic assemblies called ganglioside nanodomains. As gangliosides are important biological molecules involved in a …
  • Role of glycosylation in TGF-β signaling and epithelial-to-mesenchymal transition in cancer. [Review]
    Protein Cell. 2020 Jun 25 [Online ahead of print]Zhang J, Ten Dijke P, … Zhang T
  • Glycosylation is a common posttranslational modification on membrane-associated and secreted proteins that is of pivotal importance for regulating cell functions. Aberrant glycosylation can lead to uncontrolled cell proliferation, cell-matrix interactions, migration and differentiation, and has been shown to be involved in cancer and other diseases. The epithelial-to-mesenchymal transition is a k…
  • IGSF3 mutation identified in patient with severe COPD alters cell function and motility. [Journal Article]
    JCI Insight. 2020 Jun 23 [Online ahead of print]Schweitzer KS, Jinawath N, … Petrache I
  • Cigarette smoking (CS) and genetic susceptibility determine the risk for development, progression, and severity of chronic obstructive pulmonary diseases (COPD). We posited that an incidental balanced reciprocal chromosomal translocation was linked to a patient's risk of severe COPD. We determined 46,XX,t(1;4)(p13.1;q34.3) caused a breakpoint in IGSF3 (immunoglobulin superfamily, member 3) gene, …
  • Total Synthesis of Terpioside B. [Journal Article]
    Chemistry. 2020 Jun 21 [Online ahead of print]Inaba K, Endo M, … Toshima K
  • The first total synthesis of terpioside B ( 1 ) has been accomplished. Key steps include the stereoselective installments of a set of challenging 1,2- cis -glycosidic linkages. Thus, α(1,4)-linked D-galactoside was effectively constructed from a 1,2-anhydrogalactose donor and an unprotected 1,6-anhydrogalactose acceptor by using a boron-mediated aglycon delivery (BMAD) method. In addition, α-L-fu…
  • A baculoviral system for the production of human β-glucocerebrosidase enables atomic resolution analysis. [Journal Article]
    Acta Crystallogr D Struct Biol. 2020 Jun 01; 76(Pt 6):565-580.Rowland RJ, Wu L, … Davies GJ
  • The lysosomal glycoside hydrolase β-glucocerebrosidase (GBA; sometimes called GBA1 or GCase) catalyses the hydrolysis of glycosphingolipids. Inherited deficiencies in GBA cause the lysosomal storage disorder Gaucher disease (GD). Consequently, GBA is of considerable medical interest, with continuous advances in the development of inhibitors, chaperones and activity-based probes. The development o…
  • StatPearls: Genetics, X-Linked Inheritance [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Basta Marina M St. George's University, School of Medicine Pandya Ashish M. AM Saurashtra University Rajkot India. PDU Goverment Medical College & Hospital Rajkot Gujarat India BOOK
  • The X chromosome contains 867 identified genes; most of these genes are responsible for the development of tissues like bone, neural, blood, hepatic, renal, retina, ears, ear, cardiac,  skin, and teeth. There are at least 533 disorders due to the involvement of the genes on the X chromosome.[1] A 'trait' or 'disorder' determined by a gene on the X  chromosome demonstrates X-linked inheritance.  I…
  • Gold nanoparticles interacting with synthetic lipid rafts: an AFM investigation. [Journal Article]
    J Microsc. 2020 May 20 [Online ahead of print]Ridolfi A, Caselli L, … Valle F
  • Inorganic nanoparticles (NPs) represent promising examples of engineered nanomaterials, providing interesting biomedical solutions in several fields, like therapeutics and diagnostics. Despite the extensive number of investigations motivated by their remarkable potential for nanomedicinal applications, the interactions of NPs with biological interfaces are still poorly understood. The effect of N…
  • Sphingolipids controlling ciliary and microvillar function. [Review]
    FEBS Lett. 2020 May 16 [Online ahead of print]Kaiser F, Huebecker M, Wachten D
  • Cilia and microvilli are membrane protrusions that extend from the surface of many different mammalian cell types. Motile cilia or flagella are only found on specialized cells, where they control cell movement or the generation of fluid flow, whereas immotile primary cilia protrude from the surface of almost every mammalian cell to detect and transduce extracellular signals. Despite these differe…
  • Glucocerebrosidase Defects as a Major Risk Factor for Parkinson's Disease. [Review]
    Front Aging Neurosci. 2020; 12:97.Avenali M, Blandini F, Cerri S
  • Heterozygous mutations of the GBA1 gene, encoding for lysosomal enzyme glucocerebrosidase (GCase), occur in a considerable percentage of all patients with sporadic Parkinson's disease (PD), varying between 8% and 12% across the world. Genome wide association studies have confirmed the strong correlation between PD and GBA1 mutations, pointing to this element as a major risk factor for PD, possibl…
  • Lipid accumulation controls the balance between surface connection and scission of caveolae. [Journal Article]
    Elife. 2020 May 04; 9Hubert M, Larsson E, … Lundmark R
  • Caveolae are bulb-shaped invaginations of the plasma membrane (PM) that undergo scission and fusion at the cell surface and are enriched in specific lipids. However, the influence of lipid composition on caveolae surface stability is not well described or understood. Accordingly, we inserted specific lipids into the cell PM via membrane fusion and studied their acute effects on caveolae dynamics.…
  • Glycosphingolipids Recognized by Acinetobacter baumannii. [Journal Article]
    Microorganisms. 2020 Apr 23; 8(4)Madar Johansson M, Azzouz M, … Teneberg S
  • Acinetobacter baumannii is an opportunistic bacterial pathogen associated with hospital-acquired infections, including pneumonia, meningitis, bacteremia, urinary tract infection, and wound infections. Recognition of host cell surface carbohydrates plays a crucial role in adhesion and enables microbes to colonize different host niches. Here the potential glycosphingolipid receptors of A. baumannii…
  • Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics. [Review]
    Front Plant Sci. 2020; 11:357.Kytidou K, Artola M, … Aerts JMFG
  • Plants contain numerous glycoconjugates that are metabolized by specific glucosyltransferases and hydrolyzed by specific glycosidases, some also catalyzing synthetic transglycosylation reactions. The documented value of plant-derived glycoconjugates to beneficially modulate metabolism is first addressed. Next, focus is given to glycosidases, the central theme of the review. The therapeutic value …
  • The role of lipid species in membranes and cancer-related changes. [Review]
    Cancer Metastasis Rev. 2020 Apr 20 [Online ahead of print]Skotland T, Kavaliauskiene S, Sandvig K
  • Several studies have demonstrated interactions between the two leaflets in membrane bilayers and the importance of specific lipid species for such interaction and membrane function. We here discuss these investigations with a focus on the sphingolipid and cholesterol-rich lipid membrane domains called lipid rafts, including the small flask-shaped invaginations called caveolae, and the importance …
  • LecA (PA-IL): A Galactose-Binding Lectin from Pseudomonas aeruginosa. [Journal Article]
    Methods Mol Biol. 2020; 2132:257-266.Kuhaudomlarp S, Gillon E, … Imberty A
  • LecA/PA-IL (Pfam PF07828) is a soluble galactose-binding lectin from bacterium Pseudomonas aeruginosa. The lectin is specific for α-galactose present on glycosphingolipids of the globoside family and has therefore been proposed to play a role in cell adhesion and in internalization of bacteria in epithelial cells. The lectin has also direct toxic activity. Search for high-affinity inhibitors can …
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