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(glycosyl phosphatidyl inositol anchor protein)
337 results
  • Novel Glypican-3-Binding Peptide for in Vivo Hepatocellular Carcinoma Fluorescent Imaging. [Journal Article]
    Bioconjug Chem 2016; 27(3):831-9Zhu D, Qin Y, … Zhu L
  • Glypican-3 (GPC3) is a key member of the glypican family that is expressed on the cell surface by a glycosyl-phosphatidyl-inositol (GPI) anchor. It plays a significant role in hepatocellular carcinoma (HCC) development, angiogenesis, and metastasis. Most HCC overexpress GPC3, whereas little GPC3 can be detected in normal adult liver and benign liver lesions. Therefore, it is important to understa…
  • Cholesterol balance in prion diseases and Alzheimer's disease. [Review]
    Viruses 2014; 6(11):4505-35Hannaoui S, Shim SY, … Gilch S
  • Prion diseases are transmissible and fatal neurodegenerative disorders of humans and animals. They are characterized by the accumulation of PrPSc, an aberrantly folded isoform of the cellular prion protein PrPC, in the brains of affected individuals. PrPC is a cell surface glycoprotein attached to the outer leaflet of the plasma membrane by a glycosyl-phosphatidyl-inositol (GPI) anchor. Specifica…
  • The glycome of normal and malignant plasma cells. [Journal Article]
    PLoS One 2013; 8(12):e83719Moehler TM, Seckinger A, … Schwartz-Albiez R
  • The glycome, i.e. the cellular repertoire of glycan structures, contributes to important functions such as adhesion and intercellular communication. Enzymes regulating cellular glycosylation processes are related to the pathogenesis of cancer including multiple myeloma. Here we analyze the transcriptional differences in the glycome of normal (n = 10) and two cohorts of 332 and 345 malignant plasm…
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