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15,060 results
  • Methimazole-Induced Leukocytoclastic Vasculitis: A Case Report. [Case Reports]
    Case Rep Dermatol 2019 Sep-Dec; 11(3):303-309Tawanwongsri W, Chayavichitsilp P
  • Major identifiable causes of leukocytoclastic vasculitis include certain infections and medications. Amongst antithyroid drugs, methimazole (MMI) is rarely implicated as a culprit drug. We report the first case, in Thailand, of MMI-induced leukocytoclastic vasculitis in a 41-year-old Thai female who had received MMI for relapsed Graves' disease. MMI was discontinued and cholestyramine at a dose o…
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Antithyroid Agents [BOOK]
    National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • Hyperthyroidism is defined as excessive thyroid function and is typically manifested by thyrotoxicosis as marked by clinical symptoms and excess circulating thyroid hormone. The major causes of hyperthyroidism are Graves disease, toxic multinodular goiter and toxic adenoma. Hyperthyroidism may also be caused by TSH-secreting pituitary tumors, acute or subacute thyroiditis, and excessive thyroid h…
  • Healing of Graves' Disease Thorough Lifestyle Changes: A Case Report. [Case Reports]
    Adv Mind Body Med 2019 Spring; 33(2):4-11Brogan K, Marcelino G, … Siefert A
  • CONCLUSIONS: This case report demonstrates that Graves' disease can effectively be put into lasting remission without conventional medical interventions. It also emphasizes the importance of a healthy lifestyle as a first line intervention for all patients but especially in the particular case of patients suffering from Graves' disease.
  • Propylthiouracil-induced agranulocytosis as a rare complication of antithyroid drugs in a patient with Graves' disease. [Case Reports]
    Rev Assoc Med Bras (1992) 2019; 65(6):755-760Rabelo PN, Rabelo PN, … Reis MAL
  • CONCLUSIONS: We describe here the case of a young male patient with GD. For the treatment of hyperthyroidism, thioamides are effective options. Agranulocytosis induced by ATDs is a rare complication defined as the occurrence of a granulocyte count <500/mm3 after the use of ATDs. PTU was suspended, and filgrastim and antibiotics were prescribed. Radioiodine (RAI) or surgery are therapeutic alternatives. Due to problems with ATD use, a total thyroidectomy was proposed. The preoperative preparation was performed with beta-blocker, glucocorticoid, lithium carbonate, and Lugol solution. Cholestyramine is also an option for controlling hyperthyroidism. TT was performed without postoperative complications.Thionamide-induced agranulocytosis is a rare complication. With a contraindication to ATDs, RAI and surgery are definitive therapeutic options in GD. Beta-blockers, glucocorticoids, lithium carbonate, iodine, and cholestyramine may be an adjunctive therapy for hyperthyroidism.
  • The Th1 chemokine MIG in Graves' Disease: a narrative review of the literature. [Review]
    Clin Ter 2019 Jul-Aug; 170(4):e285-e290Giusti C
  • Type-1 helper (Th1) dependent chemokines, such as monokine induced by interferon (IFN)-γ (MIG) seem to contribute to the Graves' disease (GD) pathogenesis. The thyrocytes secrete the chemokine (C-X-C motif) ligand (CXCL)10 under the IFN-γ influence. Therefore, high levels of MIG in peripheral liquids indicate a Th1 orientated immune response and are associated with the active phase of GD in hyper…
  • Propylthiouracil-induced organizing pneumonia: A case report. [Case Reports]
    Medicine (Baltimore) 2019; 98(27):e16284Xiao XW, An J, … Luo BL
  • CONCLUSIONS: Here we report the first case of histologically confirmed OP induced by PTU and conduct a literature review of the cases of PTU-induced interstitial pneumonia. The awareness of PTU-induced OP can help physicians reduce the possibility of misdiagnosis.
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