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(gonadorelin hydrochloride)
36,747 results
  • Treatment of Breast Cancer With Gonadotropin-Releasing Hormone Analogs. [Review]
    Front Oncol 2019; 9:943Huerta-Reyes M, Maya-Núñez G, … Aguilar-Rojas A
  • Although significant progress has been made in the implementation of new breast cancer treatments over the last three decades, this neoplasm annually continues to show high worldwide rates of morbidity and mortality. In consequence, the search for novel therapies with greater effectiveness and specificity has not come to a stop. Among the alternative therapeutic targets, the human gonadotropin-re…
  • Activation of a classic hunger circuit slows luteinizing hormone pulsatility. [Journal Article]
    Neuroendocrinology 2019Coutinho E, Prescott M, … Campbell RE
  • CONCLUSIONS: These data demonstrate the ability of NPY/AgRP neuronal signaling to modulate and, specifically, reduce GnRH/LH pulse generation. The findings suggest a mechanism by which increased activity of this hunger circuit, in response to negative energy balance, mediates impaired fertility in otherwise reproductively fit states, and highlight a potential mechanism to slow LH pulsatility in female infertility disorders, such as PCOS, that are associated with hyperactive LH secretion.
  • Suitability of GnRH Receptors for Targeted Photodynamic Therapy in Head and Neck Cancers. [Journal Article]
    Int J Mol Sci 2019; 20(20)Pethő L, Murányi J, … Mező G
  • Head and neck squamous cell carcinomas (HNSCC) have a high mortality rate, although several potential therapeutic targets have already been identified. Gonadotropin-releasing hormone receptor (GnRH-R) expression is less studied in head and neck cancers, hence, we investigated the therapeutic relevance of GnRH-R targeting in HNSCC patients. Our results indicate that half of the patient-derived sam…
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