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10,400 results
  • Simplified steps to heterologous prime-boost HIV vaccine development? [Journal Article]
    J Clin Invest 2019Michael NL
  • The RV 144 HIV vaccine efficacy study showed a reduction in HIV-1 infection risk in Thai volunteers who received two priming vaccinations of vCP1521 ALVAC (attenuated recombinant canarypox virus expressing HIV group-specific antigen, polymerase, and envelope genes) followed by two additional ALVAC vaccinations and coadministration of purified bivalent gp120 proteins (AIDSVAX B/E). In this issue o…
  • DNA priming and gp120 boosting induces HIV-specific antibodies in a randomized clinical trial. [Journal Article]
    J Clin Invest 2019Rouphael NG, Morgan C, … HVTN 105 Protocol Team and the NIAID HIV Vaccine Trials Network
  • BACKGROUND RV144 is the only preventive HIV vaccine regimen demonstrating efficacy in humans. Attempting to build upon RV144 immune responses, we conducted a phase 1, multicenter, randomized, double-blind trial to assess the safety and immunogenicity of regimens substituting the DNA-HIV-PT123 (DNA) vaccine for ALVAC-HIV in different sequences or combinations with AIDSVAX B/E (protein).METHODS One…
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