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287,723 results
  • Long-term neurocognitive and other side effects of radiotherapy, with or without chemotherapy, for glioma. [Review]
    Cochrane Database Syst Rev 2019; 8:CD013047Lawrie TA, Gillespie D, … Grant R
  • CONCLUSIONS: Radiotherapy for gliomas with a good prognosis may increase the risk of neurocognitive side effects in the long term; however the magnitude of the risk is uncertain. Evidence on long-term neurocognitive side effects associated with chemoradiotherapy is also uncertain. Neurocognitive assessment should be an integral part of long-term follow-up in trials involving radiotherapy for lower-grade gliomas to improve the certainty of evidence regarding long-term neurocognitive effects. Such trials should also assess other potential long-term effects, including endocrine dysfunction, and evaluate costs and cost effectiveness.
  • Political priority and pathways to scale-up of childhood cancer care in five nations. [Journal Article]
    PLoS One 2019; 14(8):e0221292Denburg AE, Ramirez A, … Atun R
  • CONCLUSIONS: The importance of key health system actors in determining the relative political priority for childhood cancer in the countries studied points to actor power as a critical enabler of prioritization in other LMIC. Responsiveness to political contexts-in particular, rhetorical and policy priority placed on NCDs and UHC-will be crucial to efforts to place childhood cancer firmly on national health agendas. National governments must be convinced of the potential for foundational health system strengthening through attention to childhood cancer care, and the presence and capability of networked actors primed to amplify public sector investments and catalyze change on the ground.
  • Colobine forestomach anatomy and diet. [Journal Article]
    J Morphol 2019Matsuda I, Chapman CA, Clauss M
  • Colobine monkeys have complex, multichambered, foregut-fermenting stomachs with either three ("tripartite") or four ("quadripartite," adding the praesaccus) chambers where a commensal microbiome digests plant cell walls and possibly detoxifies defensive plant chemicals. Although different potential functions for the praesaccus have been suggested, little evidence exists to support any of the prop…
  • Molecular pathways of senescence regulate placental structure and function. [Journal Article]
    EMBO J 2019; :e100849Gal H, Lysenko M, … Krizhanovsky V
  • The placenta is an autonomous organ that maintains fetal growth and development. Its multinucleated syncytiotrophoblast layer, providing fetal nourishment during gestation, exhibits characteristics of cellular senescence. We show that in human placentas from pregnancies with intrauterine growth restriction, these characteristics are decreased. To elucidate the functions of pathways regulating sen…
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