- Formulation optimization, in vitro characterization and stability studies of sustain release tablets of Ketoprofen. [Journal Article]
- PJPak J Pharm Sci 2019; 32(3 (Supplementary)):1245-1251
- The aim of the current study was to formulate sustain release (SR) tablets of ketoprofen. Five batches (batch I -V) of matrix based ketoprofen tablet were prepared by dry granulation method using hyd…
The aim of the current study was to formulate sustain release (SR) tablets of ketoprofen. Five batches (batch I -V) of matrix based ketoprofen tablet were prepared by dry granulation method using hydroxyl propyl methyl cellulose (15000cps). Compatibility of formulation excipients with drug was explored through FT-IR technique. Various physical and chemical parameters of all tablet batches were evaluated with multi-point dissolution profile (for 24hrs) for formulation optimization. Release kinetics of trials was estimated by model dependent and independent methods. Formulations having excellent quality attributes were then compared with marketed ketoprofen SR tablets. Accelerated stability study was also conducted to compute the shelf life of the optimized formulation. FT-IR scans illustrated the compatibility of ketoprofen with all tablet excipients. On the basis of testing results and controlled release pattern batch II was set to be an optimized trial having shelf life of 37 months. All trial batches (batch I-V) and the marketed brand exhibited highest linearity towards zero order and Korsmeyer-Peppas model with non-fickian anomalous transport (n=0.541-0.655).
- Comment on "Bronchiolitis Obliterans as long-term sequela of non-drug related Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in children". [Letter]
- CEClin Exp Dermatol 2019 Jul 19
- Mycoplasma pneumoniae, especially in children is a common trigger of SJS/TEN. MM lesions of EM major (EMM) are clinically similar to those of SJS/TEN and literature remains confusing between both dis…
Mycoplasma pneumoniae, especially in children is a common trigger of SJS/TEN. MM lesions of EM major (EMM) are clinically similar to those of SJS/TEN and literature remains confusing between both diseases.BO development is related to airway epithelial injury and subsequent fibroblastic proliferation. It is pathologically characterized by large airway bronchiectasis and bronchiole obstruction by inflammatory granulation tissue, which ultimately progress to fibrosis and scarring, leading to partial or total occlusion of the airway lumen. Immunomodulators should be systematically used concomitantly with antibiotics to prevent possible long-term fibrotic sequelae of Mycoplasma pneumonia-induced SJS/TEN. This article is protected by copyright. All rights reserved.
- Outcomes of Vacuum Sealing Drainage Treatment Combined with Skin Flap Transplantation and Antibiotic Bone Cement on Chronic Tibia Osteomyelitis: A Case Series Study. [Journal Article]
- MSMed Sci Monit 2019 Jul 19; 25:5343-5349
- CONCLUSIONS: Vacuum sealing drainage combined with skin flap transplantation and antibiotic bone cement is an effective treatment for chronic tibia osteomyelitis.
- Metal oxyanion removal from wastewater using manganese-oxidizing aerobic granular sludge. [Journal Article]
- CChemosphere 2019 Jul 11; 236:124353
- As, Sb, and Cr are redox-sensitive and toxic heavy metal(loid)s, and redox reactions are usually involved in the treatment of substrates containing these elements. In this study, manganese-oxidizing …
As, Sb, and Cr are redox-sensitive and toxic heavy metal(loid)s, and redox reactions are usually involved in the treatment of substrates containing these elements. In this study, manganese-oxidizing aerobic granular sludge (Mn-AGS) was obtained by continuously adding Mn(II) to the sludge in a sequencing batch reactor (SBR). Morphological observations, and analyses of extracellular polymeric substances (EPS), Mn valence-states, and microbial communities were performed on the resulting sludge. After 50 days of cultivation, biogenic Mn(III,IV) oxides (bio-MnOx) accumulated up to approximately 25 mg Mn/g suspended solids (SS). X-ray photoelectron spectroscopy (XPS) revealed that the percentage of Mn(III,IV) was 87.6%. The protein (PN) component in EPS increased from 80.3 to 87.8 mg/g volatile suspended solids (VSS) during cultivation, which might be favorable for sludge granulation and heavy metal(loid) removal. Batch experiments showed that Mn-AGS was better at oxidizing As(III)/Sb(III) into less toxic As(V)/Sb(V) than traditional AGS. Remarkably, the results indicated that Mn-AGS did not oxidize Cr(III) but was able to reduce Cr(VI) into relatively harmless Cr(III). This work provided a new promising method with which to treat As(III), Sb(III), and Cr(VI) in wastewaters.
- Managing API raw material variability in a continuous manufacturing line - Prediction of process robustness. [Journal Article]
- IJInt J Pharm 2019 Jul 15; :118525
- Many studies on continuous twin-screw granulation only focus on the granulator without linking this process step to the upstream and downstream unit operations. Product critical quality attributes (C…
Many studies on continuous twin-screw granulation only focus on the granulator without linking this process step to the upstream and downstream unit operations. Product critical quality attributes (CQAs) are however not only determined by the granulation step. In this study, the possibility to manage the batch-to-batch variability of an active pharmaceutical ingredient (API) in a high drug loaded formulation on a continuous line was investigated to obtain consistent tablet CQAs. As the ultimate goal of continuous manufacturing is to produce 24/7, current study also aimed at guaranteeing long term stability of the process. To do so, previously identified API critical material attributes (CMAs) were varied together with granulation, drying and milling critical process parameters (CPPs) in a screening design of experiments to understand the influence of these factors upon product CQAs and process stability. To evaluate the factors affecting the process stability with a reduced amount of materials, process deviations recorded by process sensors were used. While product CQAs only depended on process CPPs, process stability was strongly affected by API CMAs. The effect of API batch-to-batch variability on process stability could nonetheless be managed by applying suitable granulation conditions. Therefore, appropriate ranges of CPPs were defined to ensure both product CQAs and process stability. By studying the fully integrated continuous manufacturing line, it was possible to highlight the interactions between the different unit operations and the API CMAs and to design a robust process.
- Are Fenestrated Tracheostomy Tubes Still Valuable? [Journal Article]
- AJAm J Speech Lang Pathol 2019 Jul 17; :1-10
- Purpose The purpose of this clinical focus article is to describe the frequency, indications, and outcomes of fenestrated tracheostomy tube use in a large academic institution. Method A retrospective…
Purpose The purpose of this clinical focus article is to describe the frequency, indications, and outcomes of fenestrated tracheostomy tube use in a large academic institution. Method A retrospective chart review was conducted to evaluate the use of fenestrated tracheostomy tubes between 2007 and 2017. Patients were included in the study if they were ≥ 18 years of age and received a fenestrated tracheostomy tube in the recent 10-year period. Results Of 2,000 patients who received a tracheostomy, 15 patients had a fenestrated tracheostomy tube; however, only 5 patients received a fenestrated tracheostomy tube at the study institution. The primary reason why the 15 patients received a tracheostomy was chronic respiratory failure (73%); other reasons included airway obstruction (20%) and airway protection (7%). Thirteen (87%) patients received a fenestrated tracheostomy tube for phonation purposes. The remaining 2 patients received it as a step to weaning. Of the 13 patients who received a fenestrated tracheostomy tube for phonation, only 1 patient was not able to phonate. Nine (60%) patients developed some type of complications: granulation only, 2 (13.3%); granulation and tracheomalacia, 2 (13.3%); granulation and stenosis, 4 (26.7%); and granulation, tracheomalacia, and stenosis, 1 (6.7%). Conclusions Fenestrated tracheostomy tubes may assist with phonation in patients who cannot tolerate a 1-way speaking valve; however, the risk of developing granulation tissue, tracheomalacia, and tracheal stenosis exists. Health care providers should be educated on the safe use of a fenestrated tracheostomy tube and other options available to improve phonation while ensuring patient safety.
- Accelerated and scarless wound repair by a multicomponent hydrogel through simultaneous activation of multiple pathways. [Journal Article]
- DDDrug Deliv Transl Res 2019 Jul 17
- Scarless healing of injury remains a clinical challenge because of its complicated and overlapping phases of inflammation, clearing, and regeneration. Curcumin has been already established as a poten…
Scarless healing of injury remains a clinical challenge because of its complicated and overlapping phases of inflammation, clearing, and regeneration. Curcumin has been already established as a potential wound healing agent for normal and diabetic-impaired wounds. Herein, the question has been addressed whether a well-known antioxidant cerium oxide nanoparticle (CNP) can potentiate the activity of curcumin to promote a cellular program for scarless healing. In this study, we have developed a biocompatible poly (acrylamide) hydrogel (PAGE)-based dressing material comprising of CNP and curcumin (ACC) and tested its wound healing activity in an animal model of acute wound. Characterization of the CNP- and curcumin-entrapped hydrogel dressing (ACC) demonstrated high loading efficiency and sustained release of curcumin. In a full-thickness acute wound healing model of rat, a single application of ACC dressing demonstrated higher wound healing efficacy (78%) and negligible scarring compared to dressings containing only curcumin or CNP in 7 days. Enhanced cell proliferation, higher collagen content, advanced wound maturity, re-epithelialization, and granulation tissue formation were observed using the combination of curcumin and CNP (ACC). Study of cellular mechanisms identified MCP-1 and TGF-β as the key drivers of differential and accelerated healing observed in the ACC group. These, coupled with the upregulation of growth-related signaling pathways (HER2/ErbB2, TGF-β-Smad2/3, MAPK/ERK, AKT, and VEGF), promoted almost scarless healing in animals treated with ACC. The optimized combination of curcumin and CNP used in our study shows distinct advantage and can be a better agent for complete wound healing.
- Flexible Bronchoscopy Combined with Rigid Bronchoscopy for Treatment of Scarring in the Bronchus Caused by a Foreign Body. [Case Reports]
- CRCase Rep Med 2019; 2019:4616298
- Foreign body (FB) aspiration into the tracheobronchial tree is an emergency in the pediatric department, particularly in children aged <3 years. FB granulation tissue is commonly found in children wi…
Foreign body (FB) aspiration into the tracheobronchial tree is an emergency in the pediatric department, particularly in children aged <3 years. FB granulation tissue is commonly found in children with FB aspiration. However, scarring in the bronchus caused by a FB is rare. We herein report a case involving aspiration of a plastic whistle toy with scarring in the bronchus. The scar tissue was successfully removed by interventional bronchoscopy combined with a flexible electrosurgery probe and carbon dioxide cryotherapy.
- Principles of STAGE Management for Diabetic Foot Ulcers Based on the Wagner and Texas Classification Systems. [Journal Article]
- IJInt J Low Extrem Wounds 2019 Jul 17; :1534734619863914
- The current Wagner and Texas classifications of diabetic foot ulcers (DFUs) are used worldwide to assess the extent of foot lesions, but wound treatment principles based on both the classification sy…
The current Wagner and Texas classifications of diabetic foot ulcers (DFUs) are used worldwide to assess the extent of foot lesions, but wound treatment principles based on both the classification systems are lacking. We have summarized the STAGE principles of wound treatment for clinical practice based on the Wagner and Texas classification systems. The STAGE principles refer to the principles of surgical intervention during wound treatment of DFUs and emphasize that "based on anatomical layers, the management focuses on blood supply and includes layer-by-layer incision to the infected area, maintenance of effective wound drainage, and step-by-step treatment of the wound." During treatment, microcirculation improvement and microvascular angiogenesis (A) are essential for granulation tissue formation in the bone (skeleton, S) and tendons (T) and healing of the wound with reepithelialization (E). We defined the above mentioned steps as the STAGE principles, namely, layer-by-layer incision and step-by-step management (Phase A is essential for the treatments in Phases S-T and G-E). Ulcers or gangrene formed during Phases S-T or T should be treated according to the STAGE or TAGE principles, respectively. Similar treatment principles are applied in the other phases. However, treatments at each phase are not isolated and can be performed simultaneously. The STAGE principle can be combined with the tissue, infection, moisture, and wound edge (TIME) and TIME-H chronic wound treatment principles to eliminate the shortcomings of a single principle in wound management.
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- Effectiveness of Methylene Blue in the Prevention of Stifle Joint Arthrofibrosis in Rabbit Models. [Journal Article]
- ABArch Bone Jt Surg 2019; 7(3):269-277
- CONCLUSIONS: The MB was not an effective method regarding the prevention or treatment of arthofibrosis and the subsequent osteoarthritis. In contrast with previous studies, fibrosis was lower in the high dose MB group, compared to the low dose MB group. The alterations in the range of motion were related to the reduced movement caused by the pain and stiffness of the operated joints. The current study can be considered as the first report addressing the adverse effect of MB on synovial components.