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20,498 results
  • Forces maintaining the DNA double helix. [Journal Article]
    Eur Biophys J. 2020 May 27 [Online ahead of print]Privalov PL, Crane-Robinson C
  • Despite the common acceptance that the enthalpy of DNA duplex unfolding does not depend on temperature and is greater for the CG base pair held by three hydrogen bonds than for the AT base pair held by only two, direct calorimetric measurements have shown that the enthalpic and entropic contributions of both base pairs are temperature dependent and at all temperatures are greater for the AT than …
  • The architecture of EMC reveals a path for membrane protein insertion. [Journal Article]
    Elife. 2020 May 27; 9O'Donnell JP, Phillips BP, … Hegde RS
  • Approximately 25% of eukaryotic genes code for integral membrane proteins that are assembled at the endoplasmic reticulum. An abundant and widely conserved multi-protein complex termed EMC has been implicated in membrane protein biogenesis, but its mechanism of action is poorly understood. Here, we define the composition and architecture of human EMC using biochemical assays, crystallography of i…
  • Evaluation of eutectic lidocaine/prilocaine cream for jugular blood sampling in cats. [Journal Article]
    J Feline Med Surg. 2020 May 27 [Online ahead of print]Crisi PE, De Santis F, … Luciani A
  • CONCLUSIONS: The present study provides evidence for the efficacy of the EMLA cream after a 30-min application time for jugular venepuncture in cats, together with significantly reduced stress for patients. Therefore, this study supports the routine use of EMLA cream as good practice to enhance the welfare of cats and to simplify venepuncture procedures.
  • Feeding behavior of honey bees on dry sugar. [Journal Article]
    J Insect Physiol. 2020 May 21 [Online ahead of print]Liao C, Xu Y, … Wu Z
  • The feeding habits of insects can be influenced by food abundance, nutrition, physical forces, and many other variables, which is why this topic is multidisciplinary and perennially fascinating. Although honey bees primarily feed on liquid nectar, they also can feed on dry sugar; however, the feeding mechanism for feeding on dry substances by a primarily fluid-feeding insect remains unexplored. W…
  • DSSR-enabled innovative schematics of 3D nucleic acid structures with PyMOL. [Journal Article]
    Nucleic Acids Res. 2020 May 22 [Online ahead of print]Lu XJ
  • Sophisticated analysis and simplified visualization are crucial for understanding complicated structures of biomacromolecules. DSSR (Dissecting the Spatial Structure of RNA) is an integrated computational tool that has streamlined the analysis and annotation of 3D nucleic acid structures. The program creates schematic block representations in diverse styles that can be seamlessly integrated into …
  • Quantitative and Qualitative Analyses of the Glenohumeral Ligaments: An Anatomic Study. [Journal Article]
    Am J Sports Med. 2020 May 22 [Online ahead of print]Dekker TJ, Aman ZS, … Provencher MT
  • CONCLUSIONS: Glenohumeral ligaments were consistently identified in all specimens with minor anatomic variability for the SGHL, MGHL, AIGHL, and PIGHL. Important landmarks including the cartilage surface of the humerus, the bicipital groove, and the clockface can be utilized intraoperatively when attempting anatomic repair of these structures.
  • Unraveling the structure and biological functions of RNA triple helices. [Review]
    Wiley Interdiscip Rev RNA. 2020 May 22 [Online ahead of print]Brown JA
  • It has been nearly 63 years since the first characterization of an RNA triple helix in vitro by Gary Felsenfeld, David Davies, and Alexander Rich. An RNA triple helix consists of three strands: A Watson-Crick RNA double helix whose major-groove establishes hydrogen bonds with the so-called "third strand". In the past 15 years, it has been recognized that these major-groove RNA triple helices, lik…
  • Short-term Treatment Outcomes of Facial Rejuvenation Using the Mint Lift Fine. [Journal Article]
    Plast Reconstr Surg Glob Open. 2020 Apr; 8(4):e2775.Moon HJ, Chang D, Lee W
  • CONCLUSIONS: We describe short-term treatment outcomes of facial rejuvenation using the Mint Lift Fine in patients with nasolabial folds, nasojugal groove, marionette lines, or sagging jowl. But further large-scale, prospective, multicenter studies with long periods of follow-up are, therefore, warranted to establish our results.
  • The Mechanism of β2m Molecule-Induced Changes in the Peptide Presentation Profile in a Bony Fish. [Journal Article]
    iScience. 2020 May 22; 23(5):101119.Li Z, Zhang N, … Xia C
  • Contemporary antigen presentation knowledge is based on the existence of a single β2m locus, and a classical MHC class I forms a complex with a peptide (i.e., pMHC-I) to trigger CTL immunity. However, two β2m loci have been found in diploid bony fish; the function of the two β2m molecules is unclear. Here, we determined the variant peptide profiles originating from different products of the β2m l…
  • Preparation of the lingual canal in mandibular first premolar with canal bifurcation. [Journal Article]
    Odontology. 2020 May 20 [Online ahead of print]Lu Y, Liu Y, … Gu Y
  • The aim of this study was to establish an effective method of locating and negotiating the lingual canal in mandibular first premolars with two canals during root canal preparation. A total of 125 mandibular first premolars with radicular grooves were collected, and after micro-computed tomography scanning, 50 mandibular first premolars with a Vertucci V/III canal form were selected based on the …
  • A new member of fossil balaenid (Mysticeti, Cetacea) from the early Pliocene of Hokkaido, Japan. [Journal Article]
    R Soc Open Sci. 2020 Apr; 7(4):192182.Tanaka Y, Furusawa H, Kimura M
  • The family Balaenidae includes two genus and four extant species. Extinct balaenids are known for at least four genus and 10 species. The oldest known record of members of the Balaenidae is known from the early Miocene, but still need more early members of the family to provide better phylogenetic hypotheses. FCCP 1049 from the lower part of the Chippubetsu Formation, Fukagawa Group (3.5-5.2 Ma, …
  • Crystal structure of the NS3-like helicase from Alongshan virus. [Journal Article]
    IUCrJ. 2020 May 01; 7(Pt 3):375-382.Gao X, Zhu K, … Cui S
  • Alongshan virus (ALSV) is an emerging human pathogen that was identified in China and rapidly spread to the European continent in 2019, raising concerns about public health. ALSV belongs to the distinct Jingmenvirus group within the Flaviviridae family with segmented RNA genomes. While segments 2 and 4 of the ALSV genome encode the VP1-VP3 proteins of unknown origin, segments 1 and 3 encode the N…
  • Sequence-structure-function relationships in class I MHC: A local frustration perspective. [Journal Article]
    PLoS One. 2020; 15(5):e0232849.Serçinoğlu O, Ozbek P
  • Class I Major Histocompatibility Complex (MHC) binds short antigenic peptides with the help of Peptide Loading Complex (PLC), and presents them to T-cell Receptors (TCRs) of cytotoxic T-cells and Killer-cell Immunglobulin-like Receptors (KIRs) of Natural Killer (NK) cells. With more than 10000 alleles, human MHC (Human Leukocyte Antigen, HLA) is the most polymorphic protein in humans. This alleli…
  • High throughput and comprehensive approach to develop multiepitope vaccine against minacious COVID-19. [Journal Article]
    Eur J Pharm Sci. 2020 May 14 [Online ahead of print]Ojha R, Gupta N, … Prajapati VK
  • The ongoing enigmatic COVID-19 outbreak, first reported from Wuhan, China, on last day of the year 2019, which has spread to 213 countries, territories/areas till 28th April, 2020, threatens hundreds of thousands human souls. This devastating viral infection has stimulated the urgent development of viable vaccine against COVID-19 across the research institutes around the globe. The World Health O…
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