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2,219 results
  • Habenula deep brain stimulation for intractable schizophrenia: a pilot study. [Journal Article]
    Neurosurg Focus. 2020 Jul; 49(1):E9.Wang Y, Zhang C, … Sun B
  • Schizophrenia is a psychiatric disorder associated with significant morbidity and mortality. Although antipsychotic medications and electroconvulsive therapy can be used to manage the clinical symptoms of schizophrenia, a substantial portion (10%-30%) of patients do not clinically respond to these treatments or cannot tolerate the side effects. Recently, deep brain stimulation (DBS) has emerged a…
  • Putative role of GPR139 on sleep modulation using pharmacological and genetic rodent models. [Journal Article]
    Eur J Pharmacol. 2020 Jun 09 [Online ahead of print]Wang L, Dugovic C, … Bonaventure P
  • GPR139 is a G-protein coupled receptor expressed in circumventricular regions of the habenula and septum. Amino acids L-tryptophan and L-phenylalanine have been shown to activate GPR139 at physiologically relevant concentrations. The aim of the present study was to investigate the role of GPR139 on sleep modulation using pharmacological and genetic (GPR139 knockout mice, KO) rodent models. To eva…
  • A systems-neuroscience model of phasic dopamine. [Journal Article]
    Psychol Rev. 2020 Jun 11 [Online ahead of print]Mollick JA, Hazy TE, … O'Reilly RC
  • We describe a neurobiologically informed computational model of phasic dopamine signaling to account for a wide range of findings, including many considered inconsistent with the simple reward prediction error (RPE) formalism. The central feature of this PVLV framework is a distinction between a primary value (PV) system for anticipating primary rewards (Unconditioned Stimuli [USs]), and a learne…
  • Heterogeneous Habenular Neuronal Ensembles during Selection of Defensive Behaviors. [Journal Article]
    Cell Rep. 2020 Jun 09; 31(10):107752.Lecca S, Namboodiri VMK, … Mameli M
  • Optimal selection of threat-driven defensive behaviors is paramount to an animal's survival. The lateral habenula (LHb) is a key neuronal hub coordinating behavioral responses to aversive stimuli. Yet, how individual LHb neurons represent defensive behaviors in response to threats remains unknown. Here, we show that in mice, a visual threat promotes distinct defensive behaviors, namely runaway (e…
  • Ectopic over expression of kiss1 may compensate for the loss of kiss2. [Journal Article]
    Gen Comp Endocrinol. 2020 May 26 [Online ahead of print]Talya E, Nilli Z, … Yoav G
  • Kisspeptin (KISS) is a neuropeptide which plays a central role in the regulation of the hypothalamic-pituitary-gonadal axis, and is essential for sexual maturation and fertility in mammals. Unlike mammals, which possess only one KISS gene, two paralogous genes, kiss1 and kiss2, have been identified in zebrafish and other non-mammalian vertebrates. Previous studies suggest that Kiss2, but not Kiss…
  • Identification of GABAergic neurons innervating the zebrafish lateral habenula. [Journal Article]
    Eur J Neurosci. 2020 May 28 [Online ahead of print]Ramaswamy M, Cheng RK, Jesuthasan S
  • Habenula neurons are constantly active. The level of activity affects mood and behaviour, with increased activity in the lateral habenula reflecting exposure to punishment and a switch to passive coping and depression. Here, we identify GABAergic neurons that could reduce activity in the lateral habenula of larval zebrafish. GAD65/67 immunohistochemistry and imaging of gad1b:DsRed transgenic fish…
  • Astrocytes in rapid ketamine antidepressant action. [Review]
    Neuropharmacology. 2020 Aug 15; 173:108158.Stenovec M, Li B, … Zorec R
  • Ketamine, a general anaesthetic and psychotomimetic drug, exerts rapid, potent and long-lasting antidepressant effect, albeit the cellular and molecular mechanisms of this action are yet to be discovered. Besides targeting neuronal NMDARs fundamental for synaptic transmission, ketamine affects the function of astroglia the key homeostatic cells of the central nervous system that contribute to pat…
  • Nectin-2α is localized at cholinergic neuron dendrites and regulates synapse formation in the medial habenula. [Editorial]
    J Comp Neurol. 2020 May 26 [Online ahead of print]Shiotani H, Miyata M, … Takai Y
  • The medial habenula (MHb) receives afferents from the triangular septum and the medial septal complex, projects efferents to the interpeduncular nucleus (IPN) in the midbrain to regulate dopamine and serotonin levels, and is implicated in stress, depression, memory, and nicotine withdrawal syndrome. We previously showed that the cell adhesion molecule nectin-2α is localized at the boundary betwee…
  • Disentangling neuronal inhibition and inhibitory pathways in the lateral habenula. [Journal Article]
    Sci Rep. 2020 May 22; 10(1):8490.Webster JF, Vroman R, … Wozny C
  • The lateral habenula (LHb) is hyperactive in depression, and thus potentiating inhibition of this structure makes an interesting target for future antidepressant therapies. However, the circuit mechanisms mediating inhibitory signalling within the LHb are not well-known. We addressed this issue by studying LHb neurons expressing either parvalbumin (PV) or somatostatin (SOM), two markers of partic…
  • Human decisions about when to act originate within a basal forebrain-nigral circuit. [Journal Article]
    Proc Natl Acad Sci U S A. 2020 May 26; 117(21):11799-11810.Khalighinejad N, Priestley L, … Rushworth MFS
  • Decisions about when to act are critical for survival in humans as in animals, but how a desire is translated into the decision that an action is worth taking at any particular point in time is incompletely understood. Here we show that a simple model developed to explain when animals decide it is worth taking an action also explains a significant portion of the variance in timing observed when h…
  • Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice. [Journal Article]
    Nat Neurosci. 2020 May; 23(5):638-650.Flanigan ME, Aleyasin H, … Russo SJ
  • Heightened aggression is characteristic of multiple neuropsychiatric disorders and can have various negative effects on patients, their families and the public. Recent studies in humans and animals have implicated brain reward circuits in aggression and suggest that, in subsets of aggressive individuals, domination of subordinate social targets is reinforcing. In this study, we showed that, in ma…
  • Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior. [Journal Article]
    Proc Natl Acad Sci U S A. 2020 Apr 28; 117(17):9594-9603.Nakayama T, Okimura K, … Yoshimura T
  • Seasonal changes in the environment lead to depression-like behaviors in humans and animals. The underlying mechanisms, however, are unknown. We observed decreased sociability and increased anxiety-like behavior in medaka fish exposed to winter-like conditions. Whole brain metabolomic analysis revealed seasonal changes in 68 metabolites, including neurotransmitters and antioxidants associated wit…
  • Transcriptional and Spatial Resolution of Cell Types in the Mammalian Habenula. [Journal Article]
    Neuron. 2020 Jun 03; 106(5):743-758.e5.Hashikawa Y, Hashikawa K, … Stuber GD
  • The habenula complex is appreciated as a critical regulator of motivated and pathological behavioral states via its output to midbrain nuclei. Despite this, transcriptional definition of cell populations that comprise both the medial habenular (MHb) and lateral habenular (LHb) subregions in mammals remain undefined. To resolve this, we performed single-cell transcriptional profiling and highly mu…
  • Circuits and functions of the lateral habenula in health and in disease. [Review]
    Nat Rev Neurosci. 2020 05; 21(5):277-295.Hu H, Cui Y, Yang Y
  • The past decade has witnessed exponentially growing interest in the lateral habenula (LHb) owing to new discoveries relating to its critical role in regulating negatively motivated behaviour and its implication in major depression. The LHb, sometimes referred to as the brain's 'antireward centre', receives inputs from diverse limbic forebrain and basal ganglia structures, and targets essentially …
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