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2,120 results
  • The Negative Affect of Protracted Opioid Abstinence: Progress and Perspectives From Rodent Models. [Review]
    Biol Psychiatry 2019Welsch L, Bailly J, … Kieffer BL
  • Opioid use disorder (OUD) is characterized by the development of a negative emotional state that develops after a history of long-term exposure to opioids. OUD represents a true challenge for treatment and relapse prevention. Human research has amply documented emotional disruption in individuals with an opioid substance use disorder, at both behavioral and brain activity levels; however, brain m…
  • [The roles of habenula and related neural circuits in neuropsychiatric diseases]. [Review]
    Zhejiang Da Xue Xue Bao Yi Xue Ban 2019; 48(3):310-317Wu Y, Zhang S, Chen Z
  • The habenula is a small and bilateral nucleus above dorsal thalamus, which contains several different types of neurons. The habenula has extensive connections with the forebrain, septum and monoaminergic nuclei in the midbrain and brainstem. Habenula is known as an 'anti-reward' nucleus, which can be activated by aversive stimulus and negative reward prediction errors. Accumulating researchs have…
  • Overexpression of Spexin 1 in the Dorsal Habenula Reduces Anxiety in Zebrafish. [Journal Article]
    Front Neural Circuits 2019; 13:53Jeong I, Kim E, … Park HC
  • Spexin (SPX) is an evolutionarily conserved neuropeptide that is expressed in the mammalian brain and peripheral tissue. Two orthologs are present in the teleost, SPX1 and SPX2. SPX1 is involved in reproduction and food intake. Recently, SPX1 neurons have been found to be located in the specific nuclei of dorsal habenula (dHb) and to project into the interpeduncular nucleus (IPN), in which galani…
  • A neural circuit for comorbid depressive symptoms in chronic pain. [Journal Article]
    Nat Neurosci 2019Zhou W, Jin Y, … Zhang Z
  • Comorbid depressive symptoms (CDS) in chronic pain are a common health problem, but the neural circuit mechanisms underlying these symptoms remain unclear. Here we identify a novel pathway involving 5-hydroxytryptamine (5-HT) projections from the dorsal raphe nucleus (5-HTDRN) to somatostatin (SOM)-expressing and non-SOM interneurons in the central nucleus of the amygdala (CeA). The SOMCeA neuron…
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