- Combinational effect of angiotensin receptor blocker and folic acid therapy on uric acid and creatinine level in hyperhomocysteinemia associated hypertension. [Review]
- BABiotechnol Appl Biochem 2019 Jul 17
- Homocysteine [HSCH2CH2CH(NH2)COOH] (Hcy), is a sulfur-containing amino acid of 135.18 Da of molecular weight, generated during conversion of methionine to cysteine. If there is a higher accumulation …
Homocysteine [HSCH2CH2CH(NH2)COOH] (Hcy), is a sulfur-containing amino acid of 135.18 Da of molecular weight, generated during conversion of methionine to cysteine. If there is a higher accumulation of Hcy in the blood, i.e. usually above 15 µmol/L, it leads to a condition referred to as hyperhomocysteinemia. A meta-analysis of observational study suggested an elevated concentration of Hcy in blood, which is termed as the risk factors leading to ischemic heart disease (IHD) and stroke. Further experimental studies stated that Hcy can lead to an increase in the proliferation of vascular smooth muscle cells and functional impairment of endothelial cells. The analyses confirmed some of the predictors for Hcy presence, such as serum uric acid (UA), systolic blood pressure, and hematocrit. However, angiotensin-converting enzyme inhibitors Angiotensin-converting enzyme (ACE) inhibitors and angiotensin converting enzyme inhibitors (ARBs) (except losartan) alone are inadequate for controlling UA and creatinine level, although the addition of folic acid may be beneficial in hypertensive patients who are known to have a high prevalence of elevated Hcy. We hypothesized that combination therapy with an ARB (olmesartan) and folic acid is a promising treatment for lowering the UA and creatinine level in hyperhomocysteinemia associated hypertension. This article is protected by copyright. All rights reserved.
- Evaluation of Effect of Statins on Erythropoietin Resistance in Patients of Chronic Kidney Disease on Maintenance Haemodialysis. [Journal Article]
- JAJ Assoc Physicians India 2018; 66(12):29-32
- CONCLUSIONS: Statin can be used as an adjuvant to erythropoietin in management of anemia in patients of chronic kidney disease, who show hyporesponsiveness to increased doses of erythropoietin, by its anti-inflammatory properties.
- Arterial and venous thrombosis by high platelet count and high hematocrit: 108,521 individuals from the Copenhagen General Population Study. [Journal Article]
- JTJ Thromb Haemost 2019 Jul 15
- CONCLUSIONS: Multivariable adjusted hazard ratios for individuals with platelet counts in the top 5 percentiles (>398 x 109 /L) versus in the 25th -75th percentiles (231-316x 109 /L) were 1.77 (95% CI: 1.38-2.24) for arterial thrombosis in the brain (38 and 26 events/10,000 person-years) and 0.82 (0.61-1.11) for arterial thrombosis in the heart (23 and 28 events/10,000 person-years). For individuals with hematocrit values in the top 5 percentiles (women/men: > 45 / > 48%) versus the 25th -75th percentiles (women/men: 38.1-42 / 41.1-45%), hazard ratios were 1.27 (0.91-1.75) for arterial thrombosis in the brain (40 and 26 events/10,000 person-years) and 1.46 (1.06-2.00) for arterial thrombosis in the heart (43 and 25 events/10,000 person-years). Neither high platelet count nor high hematocrit was associated with risk of venous thromboembolism. When excluding individuals with myeloproliferative neoplasia from the main analyses, results on risk of thrombosis were similar. In this prospective study, high platelet counts were associated with 1.8-fold risk of arterial thrombosis in the brain while high hematocrit was associated with 1.5-fold risk of arterial thrombosis in the heart. This article is protected by copyright. All rights reserved.
- Comparison of hemoglobin and hematocrit levels at 1, 4 and 24 h after red blood cell transfusion. [Journal Article]
- TATransfus Apher Sci 2019 Jul 09
- Previous studies have shown that equilibration following a red cell transfusion had occurred by 24 h. A shorter time to follow the hemoglobin (Hb) and hematocrit (Hct) after transfusion may help phys…
Previous studies have shown that equilibration following a red cell transfusion had occurred by 24 h. A shorter time to follow the hemoglobin (Hb) and hematocrit (Hct) after transfusion may help physicians to provide earlier and more pertinent treatment. This was a prospective study conducted from December 2014 to August 2015. This research aimed to determine the equilibration time point of the level of Hb and Hct after one unit red blood cell (RBC) transfusion. Patients were randomized into three groups and Hb level and Hct were assessed at one, four or 24 h after transfusion. The mean differences in Hb level and Hct before and after transfusion were compared between each group. Sixty patients were eligible for enrollment onto this study; 20 patients were therefore allocated to each group. The median age was 51 years old, male predominating (83.33%). The most common indication for transfusion was post-operative anemia (88.33%). There were no significant differences between the baseline characteristics baseline Hb, Hct and volume of RBC transfusion in each group. The mean differences in Hb (g/dl)/Hct (%) level at the different time points of one, four and 24 h were 1.21/3.62, 1.19/3.63, and 0.95/3.09 respectively (P = 0.109 and P = 0.398, respectively). The equilibration of Hb and Hct did not differ between one, four and 24 h after a RBC transfusion. The target Hb and Hct can be determined at one hour after transfusion.
- Comparison of Intraosseous, Arterial, and Venous Blood Sampling for Laboratory Analysis in Hemorrhagic Shock. [Journal Article]
- CLClin Lab 2019 Jul 01; 65(7)
- CONCLUSIONS: Average levels of blood gases, acid base parameters, hematocrit, CK, AST, γ-GT, creatinine, and ALT, but not lactate and glucose, were similar in IO and venous samples in hypovolemia. However, precision was limited, indicating that IO test results should be confirmed when other vascular access is established, and that analysis of IO samples should be limited to acute situations and not used for detailed diagnostics in this setting.
- The Utility of MRI for Measuring Hematocrit in Fetal Anemia. [Journal Article]
- AJAm J Obstet Gynecol 2019 Jul 12
- CONCLUSIONS: Moderate-to-severe fetal anemia can be detected non-invasively by MRI with high sensitivity and specificity. Our results suggest an adjunct role for MRI in fetuses with suspected anemia, particularly following previous transfusion and in late gestation.
- Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and α-thalassemia. [Journal Article]
- PlosPLoS One 2019; 14(7):e0218040
- This study investigated the effects of hydroxyurea (HU) on hematological, biochemical and inflammatory parameters in children with sickle cell anemia (SCA) in association with βS haplotype and α-thal…
This study investigated the effects of hydroxyurea (HU) on hematological, biochemical and inflammatory parameters in children with sickle cell anemia (SCA) in association with βS haplotype and α-thalassemia. We included 22 children with SCA who were followed for an average of 14.5 months. Laboratory parameters were assessed by electronic methods, and molecular analysis was investigated by PCR-RFLP and allele-specific PCR. Results showed significant increases in hemoglobin, HbF, hematocrit, MCV, MCH, glucose, HDL-C and albumin levels, as well as significant decreases in MCHC and AST levels, WBC, neutrophils, eosinophils, lymphocytes and reticulocytes, in children during HU therapy. HbF levels were positively correlated with hemoglobin, hematocrit, MCV and total protein, yet negatively correlated with MCHC, RDW, AAT and AST during HU therapy (p<0.05). Children who carried the Central African Republic haplotype, in response to HU therapy, presented significant increases in hemoglobin, hematocrit, triglycerides and uric acid levels, as well as significant decreases in MCHC, AST and direct bilirubin levels, WBC, neutrophils, eosinophils, lymphocytes and reticulocytes. Those with the Benin haplotype presented increases in HbF and albumin levels, and a reduction in platelet counts (p<0.05). Children with α-thalassemia presented decreased ALT during HU use, while those without this deletion presented increases in hemoglobin, hematocrit, MCV, MCH, HDL-C and albumin, as well as decreases in MCHC, neutrophils, lymphocytes, reticulocytes and AST (p<0.05). Hence, regardless of its use in association with βS haplotypes or α-thalassemia, HU seems to be linked to alterations in hemolytic, inflammatory, hepatic, lipid and glycemic profiles.
- Erythropoietin improves cardiovascular function in adult rats after acute hemorrhage. [Journal Article]
- JCJ Cardiovasc Pharmacol 2019 Mar 14
- Erythropoietin (EPO) has been linked to cardioprotective effects. However, its effects during the aging process are little known. We investigated the effect of EPO administration on hemodynamic param…
Erythropoietin (EPO) has been linked to cardioprotective effects. However, its effects during the aging process are little known. We investigated the effect of EPO administration on hemodynamic parameters, cardiac function, oxidative damage, and EPO receptor (EPOR) expression pattern in hypovolemic state. EPO was administered (1000 IU/kg/3 days) and then acute hemorrhage (20% blood loss) was induced in young and adult rats. There was no difference in plasmatic EPO in either age group. Hemodynamic basal condition was similar, without alterations in renal function and hematocrit, in both age groups. After bleeding, both EPO treated age groups had increased blood pressure at the end of the experimental protocol, being greater in adult animals. EPO attenuated the tachycardic effect. Ejection fraction and fractional shortening were higher in adult EPO treated rats subjected to hemorrhage. In the left ventricle, young and adult EPO treated rats subjected to bleeding showed an increased EPOR expression. A different EPOR expression pattern was observed in the adult right atrial tissue, compared to young animals. EPO treatment decreased oxidative damage to lipids in both age groups. EPO treatment prior to acute hemorrhage improves cardiovascular function during the aging process which is mediated by different EPOR pattern expression in heart tissue.
- A randomized controlled trial of the safety and efficacy of preoperative rectal misoprostol for prevention of intraoperative and postoperative blood loss at elective cesarean delivery. [Journal Article]
- IJInt J Gynaecol Obstet 2019 Jul 15
- CONCLUSIONS: Preoperative rectal administration of misoprostol significantly reduced intraoperative and postoperative blood loss during and after elective cesarean delivery. This article is protected by copyright. All rights reserved.
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- [Quality control of red blood cell pockets produced at Centre National de Transfusion Sanguine de Lomé]. [Journal Article]
- PAPan Afr Med J 2019; 32:171
- CONCLUSIONS: we recommend to expand the interval between two blood donations and to perform hemoglobin test before blood donation in compliance with the eligibility criteria for giving blood at the National Center for Blood Transfusion in Lomé.