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46,941 results
  • Definition and Management of Patients With Primary Biliary Cholangitis and an Incomplete Response to Therapy. [Review]
    Clin Gastroenterol Hepatol. 2020 Jul 03 [Online ahead of print]Montano-Loza AJ, Corpechot C
  • Primary biliary cholangitis (PBC) is an immune-mediated chronic liver disease characterized by biliary epithelial injury, cholestasis, and progressive fibrosis that can lead to cirrhosis and requirement for liver transplantation. All patients with PBC should received initial treatment with ursodeoxycholic acid (UDCA) and odds for response are based on characteristics at baseline. It is important …
  • Combating the Hidden Health Disparity of Kernicterus in Black Infants: A Review. [Journal Article]
    JAMA Pediatr. 2020 Jul 06 [Online ahead of print]Okolie F, South-Paul JE, Watchko JF
  • CONCLUSIONS: There are multiple opportunities for intervention to reduce black kernicterus risk. Although kernicterus is a rare disorder, the incidence among black infants is not a trivial matter nor are efforts to prevent kernicterus. While the multiple interacting biologic and nonbiologic contributors to increased kernicterus risk among black infants pose a considerable challenge to clinicians, there are opportunities for intervention to reduce this risk and health disparity. Continued study is imperative to understand the current scope of kernicterus and its occurrence in black neonates.
  • Hemolytic Anemia: Sneaky Cause, Leaky Valve. [Case Reports]
    Cureus. 2020 May 31; 12(5):e8370.Rai M, Ali MU, Geller C
  • Intravascular hemolysis is a known complication of prosthetic heart valves. Severe hemolysis is rare (<1%) with the use of newer generation prosthetic valves. This usually occurs due to paravalvular leaks (PVLs). We present a case of hyperbilirubinemia and hemolytic anemia occurring as a result of a PVL of a prosthetic mechanical mitral valve. The patient was a 49-year-old female with a past medi…
  • Coronavirus disease (COVID-19) and the liver: a comprehensive systematic review and meta-analysis. [Journal Article]
    Hepatol Int. 2020 Jul 04 [Online ahead of print]Kumar-M P, Mishra S, … Sharma V
  • CONCLUSIONS: The most frequent abnormality in liver functions was hypoalbuminemia followed by derangements in gamma-glutamyl transferase and aminotransferases, and these abnormalities were more frequent in severe disease. The systematic review was, however, limited by heterogeneity in definitions of severity and liver function derangements. Graphical depiction of the summary of meta-analytic findings a) pooled prevalence of abnormalities b) Risk ratio of abnormality in severe versus non-severe COVID-19 c) standardized mean difference (SMD) between severe and non-severe group and d) pooled prevalence for parameters based on severity stratification for bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), albumin, globulin and acute hepatic injury (AHI) . Also estimates for overall/total liver disease (TLD) and chronic liver disease (CLD) amongst COVID-19 patients are depicted in a, b, d. For d) In addition to severity stratification, Overall (all studies for a particular estimate) and combined (only those studies which reported severity) estimates are provided.
  • Urgently listed lung transplant patients have outcomes similar to those of electively listed patients. [Journal Article]
    J Thorac Cardiovasc Surg. 2020 Apr 21 [Online ahead of print]Tang A, Thuita L, … Lung Transplantation Center
  • CONCLUSIONS: Urgent listing more often than not leads to transplantation. Although urgently listed patients are sicker overall, after transplant their perioperative morbidity and mortality, overall survival, and allograft function are similar to those of electively listed patients. Appropriate patient selection and aggressive supportive care allow urgently listed lung transplant patients to achieve these similar post-transplant outcomes.
  • Bilirubin in metabolic syndrome and associated inflammatory diseases: New perspectives. [Review]
    Life Sci. 2020 Jul 01; 257:118032.Novák P, Jackson AO, … Yin K
  • Diabetes mellitus is one of the major global health issues, which is closely related to metabolic dysfunction and the chronic inflammatory diseases. Multiple studies have demonstrated that serum bilirubin is negatively correlated with metabolic syndrome and associated inflammatory diseases, including atherosclerosis, hypertension, etc. However, the roles of bilirubin in metabolic syndrome and ass…
  • Lyme Disease and Severe Hyperbilirubinemia: A Rare Presentation of Lyme Disease. [Case Reports]
    Cureus. 2020 May 30; 12(5):e8363.Ahmed Z, Ur Rehman A, … Ahmad S
  • A 39-year-old-man presented to the emergency room with a complaint of febrile jaundice and diffuse arthralgia. The patient had a temperature of 100°F, severe jaundice, and scleral icterus. Laboratory workup showed severe hyperbilirubinemia and elevated serum creatinine, and the rest of the serum chemistry was unremarkable. The ultrasound and computed tomography (CT) of the abdomen was normal. The…
  • Bilirubin analogues as model compounds for exciton coupling. [Journal Article]
    Phys Chem Chem Phys. 2020 Jul 02 [Online ahead of print]Lyskov I, Anda A, … Smith TA
  • A series of phycobilin analogues have been investigated in terms of coupled excitonic systems. These compounds consist of a monomer, a tetrapyrrole structurally similar to bilirubin (bR), and two conjugated bR analogues. Spectroscopic and computational methods have been used to investigate the degree of interchromophore coupling. We find the synthesised bR analogue shows stronger excitonic coupli…
  • An ultra-sensitive and easy-to-use assay for sensing human UGT1A1 activities in biological systems. [Journal Article]
    J Pharm Anal. 2020 Jun; 10(3):263-270.Zhu YD, Pang HL, … Ge GB
  • The human UDP-glucuronosyltransferase 1A1 (UGT1A1), one of the most essential conjugative enzymes, is responsible for the metabolism and detoxification of bilirubin and other endogenous substances, as well as many different xenobiotic compounds. Deciphering UGT1A1 relevance to human diseases and characterizing the effects of small molecules on the activities of UGT1A1 requires reliable tools for …
  • Bilirubin Protects Transplanted Islets by Targeting Ferroptosis. [Journal Article]
    Front Pharmacol. 2020; 11:907.Yao Q, Sun R, … Kou L
  • Islet transplantation is an attractive treatment for type 1 diabetic patients. However, transplanted islets suffered from considerable cell death due to inflammatory reactions and oxidative stress. Ferroptosis is a programmed death characterized by iron-dependent lipid peroxidation, which has been implicated in the islet loss and dysfunction. Our previous studies showed that bilirubin displayed p…
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