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3,561 results
  • Intrathecal injection of Brilliant Blue G, a P2X7 antagonist, attenuates the exercise pressor reflex in rats. [Journal Article]
    Am J Physiol Regul Integr Comp Physiol. 2020 Jul 01 [Online ahead of print]Estrada JA, Ducrocq GP, … Kaufman MP
  • Purinergic 2X receptors (P2X) on the endings of group III and IV afferents play a role in evoking the exercise pressor reflex. Particular attention has been paid to P2X3 receptors because their blockade in the periphery attenuated this reflex. In contrast, nothing is known about the role played by P2X receptors in the spinal cord in evoking the exercise pressor reflex in rats. P2X7 receptors, in …
  • Coccidioidal meningitis in non-AIDS patients. A case series at a Mexican neurological referral center. [Journal Article]
    Clin Neurol Neurosurg. 2020 Jun 15; 196:106011.Cárdenas G, Aristizábal S, … Hernández F
  • CONCLUSIONS: Coccidioidal meningitis is an entity with high mortality rates. More than one half of patients suffered disseminated disease. Although meningeal signs are not frequent in chronic meningitis, more than two-thirds of our patients showed mild nuchal rigidity. In addition, cerebral and cerebellar volume loss, associated with cognitive impairment and depression, was often observed in surviving patients during the clinical-radiological follow-up.
  • miR-129-5p and miR-130a-3p Regulate VEGFR-2 Expression in Sensory and Motor Neurons during Development. [Journal Article]
    Int J Mol Sci. 2020 May 28; 21(11)Glaesel K, May C, … Theis V
  • The wide-ranging influence of vascular endothelial growth factor (VEGF) within the central (CNS) and peripheral nervous system (PNS), for example through effects on axonal growth or neuronal cell survival, is mainly mediated by VEGF receptor 2 (VEGFR-2). However, the regulation of VEGFR-2 expression during development is not yet well understood. As microRNAs are considered to be key players durin…
  • Spinal cord infarction during venoarterial-extracorporeal membrane oxygenation support. [Journal Article]
    J Artif Organs. 2020 May 30 [Online ahead of print]Le Guennec L, Shor N, … Luyt CE
  • Spinal cord infarction (SCI) is a rare disease among central nervous system vascular diseases. Only a little is known about venoarterial extracorporeal membrane oxygenation (VA-ECMO)-related SCI. Retrospective observational study conducted, from 2006 to 2019, in a tertiary referral center on patients who developed VA-ECMO-related neurovascular complications, focusing on SCI. During this period, a…
  • Transverse myelitis associated with Crohn's disease: an exceptional case, idiopathic or secondary? [Journal Article]
    Rev Esp Enferm Dig. 2020 May; 112(5):418-419.Castillo López G, Lumbreras Cabrera M
  • Transverse myelitis (TM) is a serious inflammatory disorder of the spinal cord. The annual incidence is 1 to 5 cases per million people. It produces sensory, motor and autonomic symptoms. Once metabolic and vascular causes and demyelinating diseases have been ruled out, they can be classified as paraneoplastic, parainfectious (up to half debut after infection), toxic-pharmacological (TNFα recepto…
  • The Effects of Spinal Cord Stimulators on End Organ Perfusion: A Literature Review. [Review]
    Cureus. 2020 Mar 12; 12(3):e7253.Saini HS, Shnoda M, … Tariq S
  • Spinal cord stimulators (SCS) have been gaining momentum in the last decade as their role in the management of chronic pain has become more apparent. Our intention was to search, analyze and highlight the effects of spinal cord stimulators on end-organ perfusion. We also looked at vascular diseases of atherosclerotic and nonatherosclerotic nature by examining objective evidence of improved circul…
  • Neural activity regulates autoimmune diseases through the gateway reflex. [Review]
    Bioelectron Med. 2019; 5:14.Stofkova A, Murakami M
  • The brain, spinal cord and retina are protected from blood-borne compounds by the blood-brain barrier (BBB), blood-spinal cord barrier (BSCB) and blood-retina barrier (BRB) respectively, which create a physical interface that tightly controls molecular and cellular transport. The mechanical and functional integrity of these unique structures between blood vessels and nervous tissues is critical f…
  • Platelets in Amyloidogenic Mice Are Activated and Invade the Brain. [Journal Article]
    Front Neurosci. 2020; 14:129.Kniewallner KM, de Sousa DMB, … Aigner L
  • Alzheimer's disease (AD) is a neurodegenerative disease with a complex and not fully understood pathogenesis. Besides brain-intrinsic hallmarks such as abnormal deposition of harmful proteins, i.e., amyloid beta in plaques and hyperphosphorylated Tau in neurofibrillary tangles, blood-derived elements, in particular, platelets have been discussed to be involved in AD pathogenesis. The underlying m…
  • Role of mTOR and VEGFR Inhibition in Prevention of Metastatic Tumor Growth in the Spine. [Journal Article]
    Front Oncol. 2020; 10:174.Kratzsch T, Piffko A, … Vajkoczy P
  • Objective: Spinal metastatic disease remains a major problem of oncological diseases. Patients affected may suffer pain, spinal instability, and severe neurological deficits. Today, palliative surgery and radiotherapy are the mainstays of therapy. In contrast, preventive treatment strategies or treatment concepts for an early stage are lacking. Here, we have used a syngeneic, experimental spine …
  • Fenestrated endovascular repair for diseases involving the aortic arch. [Journal Article]
    J Vasc Surg. 2020 May; 71(5):1464-1471.Tsilimparis N, Law Y, … Kölbel T
  • CONCLUSIONS: Fenestrated endograft repair of aortic arch disease is a feasible technique with a high technical success rate and acceptable rates of stroke and paraplegia. A high number of secondary interventions were needed to complete the treatment of underlying diseases.
  • First case report of nematode parasitic myelopathy in a wild feline in Brazil. [Journal Article]
    Rev Bras Parasitol Vet. 2020; 29(1):e014619.Dazzi CC, Santos AD, … Motta ACD
  • Parasitic myelopathy caused by Gurltia paralysans in domestic cats is a disease commonly reported in several South American countries. The adult parasite is lodged in the meningeal veins and spinal cord, often causing clinical manifestations of vascular proliferation, thrombophlebitis, and medullary compression. Wild felines are believed to be the definitive hosts of this parasite. The infection …
  • Reactivation of Histoplasmosis Disseminated into the Central Nervous System Presenting as a Stroke. [Case Reports]
    Cureus. 2019 Dec 31; 11(12):e6525.Klumpp L, Liu-Young G, … Shah R
  • Histoplasmosis is one of the most prevalent endemic mycosis in the United States. Patients with a previous history of histoplasmosis have a risk of reinfection in the future. Individuals with impaired immunity and those who have massive re-exposure to H. capsulatum, their defenses against this organism can be overwhelmed and diseases can recur. We present a unique case of reactivation disseminate…
  • A Rare and Treatable Cause of Medullar Claudication: Spinal Dural Arteriovenous Fistula. [Case Reports]
    Ochsner J. 2019 Winter; 19(4):397-400.Derollez C, Tard C, … Pruvo JP
  • CONCLUSIONS: Physicians should be aware of the specific abnormalities shown on spinal cord MRI that indicate dural arteriovenous fistula, as well as the criteria for performing medullar angiography, so that the condition can be diagnosed and treated in a timely manner. Early therapeutic treatment is the principal prognosis factor.
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