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5,911 results
  • Synovial fluid erythrophagocytosis: inflammation or drug-induced change? [Letter]
    Cytopathology 2019Handra-Luca A, Challal S
  • Erythrophagocytosis (EPC) may be detected on microscopy examination by the presence of erythrocytes in the cytoplasm of phagocytes. This type of phagocytosis is rarely described in the medical literature, including medical textbooks. Recent reports mention EPC in peripheral blood samples in severe cold agglutinin disease; in parvovirus-B19 and Epstein Barr virus associated warm IgM-mediated hemol…
  • Burden and etiopathogenesis of acute kidney injury in the tropics. [Journal Article]
    Clin Nephrol 2019Arogundade FA, Omotoso BA, … Balogun RA
  • Acute kidney injury (AKI) is prevalent and is associated with high morbidity and mortality globally. The epidemiology differs remarkably between developing and developed economies. Infections, diarrheal illnesses, obstetric causes and nephrotoxins are very rampant in the tropics. Even though the etiologies are different, the final common pathway in the pathogenesis is similar - tubular damage or …
  • Prediction of thrombosis risk in patients with paroxysmal nocturnal hemoglobinuria. [Journal Article]
    Ann Hematol 2019Huang Y, Liu X, … Han B
  • Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic disease with thrombosis as a major complication. The mechanism of thrombosis and related risk factors in PNH patients are still not well characterized. We retrospectively enrolled 99 patients with newly diagnosed PNH at our institute from 2011 to 2016. According to binary logistic regression model analysis, we first identified fou…
  • [Aplastic anemia following drug-induced liver injury]. [Journal Article]
    Rinsho Ketsueki 2019; 60(7):779-784Nagai J, Matsukawa T, … Miyagishima T
  • Aplastic anemia (AA), a hematopoietic disorder characterized by hypocellular bone marrow, is caused by immunologically-mediated hematopoietic stem cell injury. Viral infection is hypothesized as the underlying cause of hepatitis-associated AA, although its mechanism is still unclear. This report describes a case of AA following suspected drug-induced liver injury (DILI). An 18-year-old man develo…
  • Different Levels of Incomplete Terminal Pathway Inhibition by Eculizumab and the Clinical Response of PNH Patients. [Journal Article]
    Front Immunol 2019; 10:1639Harder MJ, Höchsmann B, … Schmidt CQ
  • CONCLUSIONS: The occurrence of extraordinary high levels of residual terminal pathway activity in PNH patients receiving Eculizumab is rare, but can impair the suppression of hemolysis. The commonly observed low levels of residual terminal pathway activity seen for most PNH patients can exacerbate during severe infections and, thus, can cause pharmacodynamic breakthrough hemolysis in PNH patients treated with Eculizumab.
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