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(hemolytic uremic syndrome)
8,206 results
  • Development and Validation of Shiga Toxin-Producing Escherichia coli Immunodiagnostic Assay. [Journal Article]
    Microorganisms 2019; 7(9)Silva MA, Santos ARR, … Piazza RMF
  • Shiga toxin (Stx)-producing Escherichia coli (STEC) and its subgroup enterohemorrhagic E. coli are important pathogens involved in diarrhea, which may be complicated by hemorrhagic colitis and hemolytic uremic syndrome, the leading cause of acute renal failure in children. Early diagnosis is essential for clinical management, as an antibiotic treatment in STEC infections is not recommended. Previ…
  • Severe and malignant hypertension are common in primary atypical hemolytic uremic syndrome. [Journal Article]
    Kidney Int 2019Cavero T, Arjona E, … Spanish Group for the Study of Glomerular Diseases (GLOSEN)
  • Malignant hypertension is listed among the causes of secondary thrombotic microangiopathy (TMA), but pathogenic mutations in complement genes have been reported in patients with hypertension-induced TMA. Here we investigated the frequency and severity of hypertension in 55 patients with primary atypical hemolytic uremic syndrome (aHUS). A genetic analysis was performed in all patients, and fundus…
  • Development of a Gold Nanoparticle Vaccine against Enterohemorrhagic Escherichia coli O157:H7. [Journal Article]
    MBio 2019; 10(4)Sanchez-Villamil JI, Tapia D, Torres AG
  • Here we exploit the natural properties of a synthetic nanoparticle (NP) scaffold as a subunit vaccine against enterohemorrhagic Escherichia coli (EHEC). Two EHEC-specific immunogenic antigens, namely, LomW and EscC, either alone or in combination, were covalently linked on the surface of gold nanoparticles (AuNPs) and used to immunize mice prior to challenge with EHEC O157:H7 strain 86-24. LomW i…
  • A review of thrombotic microangiopathies in multiple myeloma. [Review]
    Leuk Res 2019; 85:106195Portuguese AJ, Gleber C, … Lipe B
  • Patients with multiple myeloma (MM) are susceptible to developing thrombotic microangiopathies (TMAs), an etiologically diverse group of syndromes which include atypical hemolytic uremic syndrome (aHUS) and thrombotic thrombocytopenic purpura (TTP). The TMAs are characterized by thrombocytopenia and microangiopathic hemolytic anemia (MAHA), and are associated with a high mortality risk and irreve…
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