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(hepatocarcinogen)
899 results
  • Association between aflatoxin-albumin adduct levels and tortilla consumption in Guatemalan adults. [Journal Article]
    Toxicol Rep 2019; 6:465-471Kroker-Lobos MF, Alvarez CS, … Groopman JD
  • Aflatoxin B1 (AFB1) is a known human hepatocarcinogen and a recent study reported elevated AFB1 levels, measured by serum albumin biomarkers, among Guatemalan adults. While AFB1 can contaminate a variety of foodstuffs, including maize, Guatemala's main dietary staple, the relationship of maize intake to serum AFB1-albumin adducts levels in Guatemala has not been previously examined. As a result, …
  • Aflatoxin B1 metabolism: Regulation by phase I and II metabolizing enzymes and chemoprotective agents. [Review]
    Mutat Res 2018 Oct - Dec; 778:79-89Deng J, Zhao L, … Sun LH
  • Aflatoxin B1 (AFB1) widely contaminates staple food and feed crops and is well-known as the most potent natural hepatocarcinogen in humans and domesticated animals. This review highlights significant advances in our understanding of the pivotal role of phase I and II metabolizing enzymes in the bioactivation and detoxification of AFB1 and its metabolites across species. In humans, cytochrome P450…
  • Processing of N5-substituted formamidopyrimidine DNA adducts by DNA glycosylases NEIL1 and NEIL3. [Journal Article]
    DNA Repair (Amst) 2019; 73:49-54Minko IG, Christov PP, … Lloyd RS
  • A variety of agents cause DNA base alkylation damage, including the known hepatocarcinogen aflatoxin B1 (AFB1) and chemotherapeutic drugs derived from nitrogen mustard (NM). The N7 site of guanine is the primary site of alkylation, with some N7-deoxyguanosine adducts undergoing imidazole ring-opening to stable mutagenic N5-alkyl formamidopyrimidine (Fapy-dG) adducts. These adducts exist as a mixt…
  • Chronic dietary toxicity and carcinogenicity studies of dammar resin in F344 rats. [Journal Article]
    Arch Toxicol 2018; 92(12):3565-3583Gi M, Fujioka M, … Wanibuchi H
  • Dammar resin is a natural food additive and flavoring substance present in many foods and drinks. The present study evaluates the chronic toxicity and carcinogenicity of dietary dammar resin in F344 rats. Dietary concentrations in the 52-week chronic toxicity study were 0, 0.03, 0.125, 0.5, or 2%. The major treatment-related deleterious effects were body weight suppression, increased relative liv…
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