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908 results
  • Identification of Time-Invariant Biomarkers for Non-Genotoxic Hepatocarcinogen Assessment. [Journal Article]
    Int J Environ Res Public Health. 2020 Jun 16; 17(12)Huang SH, Lin YC, Tung CW
  • Non-genotoxic hepatocarcinogens (NGHCs) can only be confirmed by 2-year rodent studies. Toxicogenomics (TGx) approaches using gene expression profiles from short-term animal studies could enable early assessment of NGHCs. However, high variance in the modulation of the genes had been noted among exposure styles and datasets. Expanding from our previous strategy in identifying consensus biomarkers…
  • Protective Effects of Dietary Capsaicin on the Initiation Step of a Two-Stage Hepatocarcinogenesis Rat Model. [Journal Article]
    Nutr Cancer. 2020 May 13 [Online ahead of print]Sarmiento-Machado LM, Romualdo GR, … Barbisan LF
  • Capsaicin (CPS), an ingredient of Capsicum plants, has anti-inflammatory, antioxidant and antitumoral properties. The mechanisms of CPS on hepatocarcinogenesis preclinical bioassays are not described. Thus, the protective effects CPS were evaluated in the early stages of chemically-induced hepatocarcinogenesis. Male Wistar rats received diet containing 0.01% or 0.02% CPS for 3 weeks. Afterwards, …
  • Aflatoxins in rice: Worldwide occurrence and public health perspectives. [Review]
    Toxicol Rep. 2019; 6:1188-1197.Ali N
  • Aflatoxins are fungal secondary metabolites that contaminate dietary staples worldwide, including maize, rice and groundnuts. Dietary exposure to aflatoxins is a public health concern due to their carcinogenic, acute and chronic effects. Rice is an important staple food consumed widely and consists of a major part of the diets for half of the world population. Human exposure to these mycotoxins i…
  • Genome sequencing of evolved aspergilli populations reveals robust genomes, transversions in A. flavus, and sexual aberrancy in non-homologous end-joining mutants. [Journal Article]
    BMC Biol. 2019 11 11; 17(1):88.Álvarez-Escribano I, Sasse C, … Cánovas D
  • CONCLUSIONS: We present for the first time direct counts of the mutation rate of filamentous fungal species and find that Aspergillus genomes are very robust. Deletion of the NHEJ machinery results in a slight increase in the mutation rate, but at a rate we suggest is still safe to use for biotechnology purposes. Unexpectedly, we found GC→TA transversions predominated only in the species A. flavus, which could be generated by the hepatocarcinogen secondary metabolite aflatoxin. Lastly, a strong effect of the NHEJ mutation in self-crossing was observed and an increase in the mutations of the asexual lines was quantified.
  • Association between aflatoxin-albumin adduct levels and tortilla consumption in Guatemalan adults. [Journal Article]
    Toxicol Rep. 2019; 6:465-471.Kroker-Lobos MF, Alvarez CS, … Groopman JD
  • Aflatoxin B1 (AFB1) is a known human hepatocarcinogen and a recent study reported elevated AFB1 levels, measured by serum albumin biomarkers, among Guatemalan adults. While AFB1 can contaminate a variety of foodstuffs, including maize, Guatemala's main dietary staple, the relationship of maize intake to serum AFB1-albumin adducts levels in Guatemala has not been previously examined. As a result, …
  • Aflatoxin B1 metabolism: Regulation by phase I and II metabolizing enzymes and chemoprotective agents. [Review]
    Mutat Res. 2018 Oct - Dec; 778:79-89.Deng J, Zhao L, … Sun LH
  • Aflatoxin B1 (AFB1) widely contaminates staple food and feed crops and is well-known as the most potent natural hepatocarcinogen in humans and domesticated animals. This review highlights significant advances in our understanding of the pivotal role of phase I and II metabolizing enzymes in the bioactivation and detoxification of AFB1 and its metabolites across species. In humans, cytochrome P450…
  • Processing of N5-substituted formamidopyrimidine DNA adducts by DNA glycosylases NEIL1 and NEIL3. [Journal Article]
    DNA Repair (Amst). 2019 01; 73:49-54.Minko IG, Christov PP, … Lloyd RS
  • A variety of agents cause DNA base alkylation damage, including the known hepatocarcinogen aflatoxin B1 (AFB1) and chemotherapeutic drugs derived from nitrogen mustard (NM). The N7 site of guanine is the primary site of alkylation, with some N7-deoxyguanosine adducts undergoing imidazole ring-opening to stable mutagenic N5-alkyl formamidopyrimidine (Fapy-dG) adducts. These adducts exist as a mixt…
  • Chronic dietary toxicity and carcinogenicity studies of dammar resin in F344 rats. [Journal Article]
    Arch Toxicol. 2018 12; 92(12):3565-3583.Gi M, Fujioka M, … Wanibuchi H
  • Dammar resin is a natural food additive and flavoring substance present in many foods and drinks. The present study evaluates the chronic toxicity and carcinogenicity of dietary dammar resin in F344 rats. Dietary concentrations in the 52-week chronic toxicity study were 0, 0.03, 0.125, 0.5, or 2%. The major treatment-related deleterious effects were body weight suppression, increased relative liv…
  • Phosphorylation of protein phosphatase 2A facilitated an early stage of chemical carcinogenesis. [Journal Article]
    Toxicol Appl Pharmacol. 2017 12 01; 336:75-83.Ishii Y, Kuroda K, … Umemura T
  • Protein phosphatase 2A (PP2A) is a serine-threonine phosphatase that regulates cell signaling pathways. Its inactivation is correlated with tumor malignancy, possibly due to the effects on cell differentiation and malignant cell transformation. Therefore, it has been noted that PP2A could be a promising target for cancer therapy. In our previous study of the hepatocarcinogen estragole (ES), cell …
  • Editor's Highlight: Pregnancy Alters Aflatoxin B1 Metabolism and Increases DNA Damage in Mouse Liver. [Journal Article]
    Toxicol Sci. 2017 Nov 01; 160(1):173-179.Sriwattanapong K, Slocum SL, … Essigmann JM
  • Pregnancy is a complex physiological state, in which the metabolism of endogenous as well as exogenous agents is ostensibly altered. One exogenous agent of concern is the hepatocarcinogen aflatoxin B1 (AFB1), a foodborne fungal toxin, that requires phase I metabolic oxidation for conversion to its toxic and carcinogenic form, the AFB1-8,9-exo-epoxide. The epoxide interacts with cellular targets c…
  • Effect of methapyrilene hydrochloride on hepatic intracellular iron metabolism in vivo and in vitro. [Journal Article]
    Toxicol Lett. 2017 Nov 05; 281:65-73.Kindrat I, Dreval K, … Pogribny IP
  • The liver, a central detoxification organ and main regulator of systemic iron homeostasis, is prone to damage by xenobiotics. In the present study, we investigated the effect of the hepatotoxicant and hepatocarcinogen methapyrilene hydrochloride on iron metabolism in rat liver in a repeat-dose in vivo toxicity study and in human HepaRG cells in vitro. Treatment of male Fischer 344 (F344) rats wit…
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