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193 results
  • Differential Vascularity in Genetic and Nonhereditary Heterotopic Ossification. [Journal Article]
    Int J Surg Pathol 2019; :1066896919857135Ware AD, Brewer N, … James AW
  • Introduction. Nonhereditary heterotopic ossification (NHO) is a common complication of trauma. Progressive osseous heteroplasia (POH) and fibrodysplasia ossificans progressiva (FOP) are rare genetic causes of heterotopic bone. In this article, we detail the vascular patterning associated with genetic versus NHO. Methods. Vascular histomorphometric analysis was performed on patient samples from P…
  • Gαs signaling in skeletal development, homeostasis and diseases. [Journal Article]
    Curr Top Dev Biol 2019; 133:281-307Cong Q, Xu R, Yang Y
  • Skeletal development is exquisitely controlled both spatially and temporally by cell signaling networks. Gαs is the stimulatory α-subunit in a heterotrimeric G protein complex transducing the signaling of G-protein-coupled receptors (GPCRs), responsible for controlling both skeletal development and homeostasis. Gαs, encoded by the GNAS gene in humans, plays critical roles in skeletal development …
  • Primary Osteoma Cutis in the Interscapular Region of a Dog. [Case Reports]
    J Comp Pathol 2019; 166:1-4Woo SH, Go DM, … Kim DY
  • A 9-year-old neutered male Shih Tzu was presented with three contiguous firm nodules in the subcutaneous tissue of the interscapular region. Histopathological examination revealed that the nodules consisted of mature lamellar bone with a Haversian system, with no apparent lesion around the bone. Clinical examination revealed that the dog had no underlying disease and no history of trauma at the l…
  • Parathyroid hormone resistance syndromes - Inactivating PTH/PTHrP signaling disorders (iPPSDs). [Review]
    Best Pract Res Clin Endocrinol Metab 2018; 32(6):941-954Elli FM, Pereda A, … Mantovani G
  • Metabolic disorders caused by impairments of the Gsα/cAMP/PKA pathway affecting the signaling of PTH/PTHrP lead to features caused by non-responsiveness of target organs, in turn leading to manifestations similar to the deficiency of the hormone itself. Pseudohypoparathyroidism (PHP) and related disorders derive from a defect of the α subunit of the stimulatory G protein (Gsα) or of downstream ef…
  • Inactivating PTH/PTHrP Signaling Disorders. [Review]
    Front Horm Res 2019; 51:147-159Mantovani G, Elli FM
  • Pseudohypoparathyroidism (PHP), pseudo-PHP, acrodysostosis, and progressive osseous heteroplasia are heterogeneous disorders characterized by physical findings, differently associated in each subtype, including short bones, short stature, a stocky build, ectopic ossifications (features associated with Albright's hereditary osteodystrophy), as well as laboratory abnormalities consistent with hormo…
  • Multiple miliary osteoma cutis: a comprehensive review and update of the literature. [Review]
    Eur J Dermatol 2018; 28(4):434-439Duarte BM, Pinheiro RR, Cabete J
  • Multiple miliary osteoma cutis consists of heterotopic foci of bone tissue in the dermis and subcutaneous tissue. Patients usually present with multiple, asymptomatic facial papules of several millimetres in diameter which cause distress regarding their cosmetic appearance. The condition is described as rare, as only a few cases have been reported since its first description in 1864 by Virchow. W…
  • StatPearls: Heterotopic Ossification [BOOK]
    StatPearls Publishing: Treasure Island (FL) Sun Eric E Hanyu-Deutmeyer Aaron A. AA Northwestern Medicine BOOK
  • Heterotopic ossification (HO) is a frequent complication in the rehabilitation setting which consists of the formation of mature, lamellar bone in the extraskeletal soft tissue where bone does not usually exist. Patient populations at risk of developing HO are those with burns, stroke, spinal cord injury (SCI), traumatic amputation, joint replacement, and traumatic brain injury (TBI). There are o…
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