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Unbound Medicine.
(human milk fortifier)
264 results
  • Fortifier selection and dosage enables control of breast milk osmolarity. [Journal Article]
    PLoS One. 2020; 15(6):e0233924.Herranz Barbero A, Rico N, … Salvia-Roigés M
  • CONCLUSIONS: Upon addition of the HMFs tested, BM osmolality increases significantly and keeps raising over time. All HMFs but the recently developed PreNAN FM85® at 4% exceed the AAP recommended threshold for osmolarity of 450 mOsm/kg. Addition of NSs to PreNAN FM85® at 4% significantly increases osmolality above 450 mOsm/Kg. Thus, using PreNAN FM85® at 5% may be preferable to adding nutritional supplements since nutritional recommendations by the ESPGHAN are reached with a lower increase in osmolality.
  • Human Milk Supplements: Principles, Practices, and Current Controversies. [Review]
    Clin Perinatol. 2020 Jun; 47(2):355-368.Premkumar MH, Massieu LA, … Gokulakrishnan G
  • Human milk is the most optimal source of nutrition for preterm and term infants. However, in most preterm infants, breast milk fails to meet the energy needs of the newborn infant. Overwhelming evidence supports the fortification of breast milk in preterm infants to facilitate better short-term outcomes. Several single-nutrient and multinutrient breast milk supplements and fortifiers are used to …
  • Parent and Provider Perspectives on the Imprecise Label of "Human Milk Fortifier" in the NICU. [Journal Article]
    Nutrients. 2020 Mar 09; 12(3)Canvasser J, Hair AB, … Taylor SN
  • In the critical care of preterm infants, feeding is complex and potentially harmful to an immature gastrointestinal system. Parents have expressed the desire to be fully informed about what is being fed to their child, as this places them in the best position to nurture their child's health. In the parent-engaged setting of the Necrotizing Enterocolitis Symposium, NICU parents expressed concern a…
  • Policy statement of enteral nutrition for preterm and very low birthweight infants. [Letter]
    Pediatr Int. 2020 Feb; 62(2):124-127.Mizuno K, Shimizu T, … Sugiyama A
  • For preterm and very low birthweight infants, the mother's own milk is the best nutrition. Based on the latest information for mothers who give birth to preterm and very low birthweight infants, medical staff should encourage and assist mothers to pump or express and provide their own milk whenever possible. If the supply of maternal milk is insufficient even though they receive adequate support,…
  • The Effect of Donor Human Milk Fortification on The Adhesion of Probiotics In Vitro. [Journal Article]
    Nutrients. 2020 Jan 09; 12(1)Mantziari A, Tölkkö S, … Rautava S
  • Preterm delivery complications are the primary cause of death among children under the age of five. Preventive strategies include the use of pasteurized donor human milk (DHM), its fortification with human milk fortifiers (protein supplements), and supplementation with probiotics. Our aim was to examine the impact of DHM and fortified DHM (FDHM) on the mucus adhesion properties of two widely used…
  • Effects of human milk fortifier properties on intrinsic probiotic bacteria. [Journal Article]
    J Perinat Med. 2020 Feb 25; 48(2):179-183.Codipilly CN, Koppel A, … Schanler RJ
  • Background To meet the nutritional needs of preterm infants, multicomponent nutrient fortifiers are added to human milk. The fortified human milk (FHM) product changes the physical and biochemical characteristics of the milk. We questioned whether such physical-chemical changes in the milk would alter intrinsic probiotic bacterial activity. The objective of the study was to evaluate the effect of…
  • Differences in Current Procedures for Handling of Expressed Mother's Milk in Danish Neonatal Care Units. [Journal Article]
    Adv Neonatal Care. 2019 Dec; 19(6):452-459.Simonsen MB, Hyldig N, Zachariassen G
  • CONCLUSIONS: This national survey established that there is significant variability in the way mother's milk is handled. Some of the procedures performed may affect the quality of the milk. It is important to implement evidence-based practice regarding storage and handling of expressed mother's milk to ensure that the quality of the milk is the best possible alternative for all preterm infants.Prospective studies are needed to examine the association between handling of human milk and changes in composition and nutritional potential of the milk.
  • ChyloBEST: Chylothorax in Infants and Nutrition with Low-Fat Breast Milk. [Journal Article]
    Pediatr Cardiol. 2020 Jan; 41(1):108-113.Neumann L, Springer T, … Dähnert I
  • Chylothorax occurs in 2.8-5% of infants after cardiac surgery and can increase morbidity and mortality. First-line conservative treatment consists of a chest tube drainage and a fat-free and medium-chain triglyceride (MCT)-enriched diet. This typically leads to a discontinuity of breast milk feeding due to high content of long-chain triglycerides within the breast milk. Modified breast milk with …
  • Human milk-derived fortifier versus bovine milk-derived fortifier for prevention of mortality and morbidity in preterm neonates. [Meta-Analysis]
    Cochrane Database Syst Rev. 2019 11 07; 2019(11)Premkumar MH, Pammi M, Suresh G
  • CONCLUSIONS: There is insufficient evidence evaluating human milk-derived fortifier with bovine milk-derived fortifier in exclusively breast milk-fed preterm infants. Low-certainty evidence from one study suggests that in exclusively breast milk-fed preterm infants human milk-derived fortifiers in comparison with bovine milk-derived fortifier may not change the risk of necrotizing enterocolitis, mortality, feeding intolerance, infection, or improve growth. Well-designed randomized controlled trials are needed to evaluate short-term and long-term outcomes.
  • Through Thick and Thin: The In Vitro Effects of Thickeners on Infant Feed Viscosity. [Journal Article]
    J Pediatr Gastroenterol Nutr. 2019 11; 69(5):e122-e128.Koo JK, Narvasa A, … Kim JH
  • CONCLUSIONS: Current thickening strategies of preterm infant feeding produces highly variable results in final feed viscosity. The unpredictable properties of gum-based thickeners raise questions about their safety profile. Objective measures of liquid viscosity and careful consideration of acidity and time are recommended for adequate comparisons of thickening regimens. Human milk continues to be the most challenging feed type to thicken.
  • A male preterm infant with cow's milk allergy to human milk fortifier showing only severe respiratory symptoms. [Case Reports]
    Fukushima J Med Sci. 2019 Aug 30; 65(2):50-54.Nakamura T, Hatanaka D, … Takahashi N
  • We report a male infant with a birthweight of 1,400 g at 29 weeks 2 days gestation diagnosed as having cow's milk allergy (CMA) due to human milk fortifier, who developed severe respiratory symptoms. The infant had no gastrointestinal symptoms; rather, the initial symptoms were apnea attacks and wheezing with a prolonged expiratory phase that progressed to severe ventilatory insufficiency requiri…
  • Early versus Delayed Fortification of Human Milk in Preterm Infants: A Systematic Review. [Journal Article]
    Neonatology. 2020; 117(1):24-32.Alyahya W, Simpson J, … Edwards CA
  • Expressed breast milk (EBM) is commonly supplemented with commercially prepared human milk fortifier to meet the additional nutritional needs of preterm infants. The optimal milk intake at which to introduce fortification is unknown. The objective of this systematic review was to compare the effect of early fortification (EF) versus that of delayed introduction of human milk fortifier (DF) on sho…
  • Solely human milk diets for preterm infants. [Review]
    Semin Perinatol. 2019 11; 43(7):151158.Taylor SN
  • Human milk provides not only ideal nutrition for infant development but also immunologic factors to protect from infection and inflammation. For the newborn preterm infant, the natural delivery of milk is not attainable, and instead pumped maternal milk, donor human milk, and human milk fortification are mainstays of clinical care. Current research demonstrates a decreased risk of necrotizing ent…
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