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21,641 results
  • Improvement in estimation of time since death by albumin and potassium concentrations in vitreous humor. [Journal Article]
    Forensic Sci Int. 2020 Jun 27; 314:110393.Focardi M, Lanzilao L, … Pinchi V
  • The measurement of the potassium concentration (K+) in vitreous humor (VH) has been a well-known adjunct for the estimation of the post-mortem interval (PMI) since the early 1960s. For years, however, many authors have been using other biochemical markers in an attempt to improve predictions. In this paper we confirm the role of K+ in the determination of the PMI adopting a linear regression mode…
  • Differential DNA methylation patterns in human Schlemm's canal endothelial cells with glaucoma. [Journal Article]
    Mol Vis. 2020; 26:483-493.Cai J, Drewry MD, … Liu Y
  • CONCLUSIONS: This study represents the first genome-wide DNA methylation profiling in cultured human primary SC cells. The DMSs were enriched in the pathways related to outflow resistance. Several DMRs were validated in glaucoma-associated genes, further suggesting the role of DNA methylation in glaucoma development. This study could provide comprehensive understanding of DNA methylation in glaucoma and its effect on aqueous humor outflow.
  • Increased levels of cytokines in the aqueous humor correlate with the severity of diabetic retinopathy. [Journal Article]
    J Diabetes Complications. 2020 May 30 [Online ahead of print]Song S, Yu X, … Dai H
  • CONCLUSIONS: The levels of these eight cytokines in the aqueous humor increased with the severity of diabetic retinopathy, especially in NVG-PDR. This study suggests that TGF-β, ICAM-1, IL-10, VEGF, and VCAM-1 may play a role in the progression of diabetic retinopathy, especially TGF-β, which may plays a significant role in NVG-PDR. These cytokines potentially may be used as biomarkers to predict the progress of diabetic retinopathy, contribute to the choice of treatment options and/or monitor treatment responses.
  • Deconstructing aqueous humor outflow - The last 50 years. [Review]
    Exp Eye Res. 2020 Jun 23 [Online ahead of print]Kaufman PL
  • Herein partially summarizes one scientist-clinician's wanderings through the jungles of primate aqueous humor outflow over the past ∼45 years. Totally removing the iris has no effect on outflow facility or its response to pilocarpine, whereas disinserting the ciliary muscle (CM) from the scleral spur/trabecular meshwork (TM) completely abolishes pilocarpine's effect. Epinephrine increases facilit…
  • The trabecular meshwork: Structure, function and clinical implications. A review of the literature. [Review]
    J Fr Ophtalmol. 2020 Jun 16 [Online ahead of print]Buffault J, Labbé A, … Baudouin C
  • Glaucoma is a blinding optic neuropathy, the main risk factor for which is increased intraocular pressure (IOP). The trabecular meshwork, located within the iridocorneal angle, is the main pathway for drainage of aqueous humor (AH) out of the eye, and its dysfunction is responsible for the IOP elevation. The trabecular meshwork is a complex, fenestrated, three-dimensional structure composed of tr…
  • Comparison of hydrophilic ophthalmic media on silicone oil emulsification. [Journal Article]
    PLoS One. 2020; 15(6):e0235067.Soós J, Resch MD, … Budai-Szűcs M
  • The aim of this study was to investigate whether and how the biological media which are in contact with silicone oil play a role in the silicone emulsification process. Commercially available Oxane 1300 silicone oil and potential hydrophilic phases of the emulsions in the eye (porcine aqueous humor, porcine vitreous and balanced salt solution) were investigated separately and in a mixture or emul…
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