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(huperzine)
627 results
  • Biotransformation of Huperzine A by Irpex lacteus-A fungal endophyte of Huperzia serrata. [Journal Article]
    Fitoterapia 2019; 138:104341Ying YM, Xu YL, … Zhan ZJ
  • The biotransformation of huperzine A (hupA), one of the characteristic bioactive constituents of the medicinal plant Huperzia serrata, by a fungal endophyte of the host plant was studied. Two previously undescribed compounds 1-2, along with a known analog 8α,15α-epoxyhuperzine A (3), were isolated and identified. The structures of all the isolates were established by spectroscopic methods includi…
  • Management of oxidative stress and other pathologies in Alzheimer's disease. [Review]
    Arch Toxicol 2019; 93(9):2491-2513Simunkova M, Alwasel SH, … Valko M
  • Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder, characterized by the formation, aggregation and accumulation of amyloid beta, perturbed metal (copper, iron and zinc) homeostasis, metal-induced oxidative stress, neuroinflammation, aberrant activity of acetylcholinesterase (AChE) and other pathologies. The aim of this review is to discuss the current therapies based on the …
  • Donepezil increases resistance to induced seizures in a mouse model of Dravet syndrome. [Journal Article]
    Ann Clin Transl Neurol 2019; 6(8):1566-1571Wong JC, Thelin JT, Escayg A
  • De novo loss-of-function mutations in SCN1A are the main cause of Dravet syndrome, a catastrophic encephalopathy characterized by recurrent early-life febrile seizures, a number of other afebrile seizure types that are often refractory to treatment, and behavioral abnormalities including social deficits, motor dysfunction, and cognitive impairment. We previously demonstrated that the reversible a…
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