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(hydrocortisone topical )
2,557 results
  • A quality by design approach to develop topical creams via hot-melt extrusion technology. [Journal Article]
    Eur J Pharm Sci 2019; 136:104948Mendonsa NS, Pradhan A, … Repka MA
  • The advantages of hot-melt extrusion technology (HME) over conventional techniques to develop topical semisolids have been established. However, this technique is not widely used for semisolid production. Therefore, the aim of this novel work was to develop creams using the melt extrusion technology while applying Quality by Design (QbD) principles to study the effects of the extrusion process pa…
  • Efonidipine-Induced Exanthematic Drug Eruption and Literature Review. [Journal Article]
    J Cardiovasc Pharmacol 2019; 73(6):394-396Davis S, Raju AR, … Cherian JJ
  • We report the case of an elderly woman who developed exanthematic drug eruption after administration of efonidipine. An 84-year-old woman presented to emergency department with complaints of generalized itching and erythema since 4 days. She was on human-soluble insulin since 11 years. In view of her hypertension and left anterior descending artery stenosis, she was initiated on aspirin, clopidog…
  • Randomized open-label trial comparing topical prescription triamcinolone to over-the-counter hydrocortisone for the treatment of phimosis. [Journal Article]
    J Pediatr Urol 2019Chamberlin JD, Dorgalli C, … Khoury AE
  • CONCLUSIONS: To the study authors' knowledge, this is the first open-label trial with direct comparison of hydrocortisone 1% cream with triamcinolone 0.1% cream. The study results support those reported in other studies when each topical steroid was compared with placebo. Limitations of the study include loss to follow-up, unblinded treatment allocation, and reduced power to detect differences by treatment frequency and duration.Over-the-counter hydrocortisone 1% cream is not inferior to triamcinolone 0.1% cream when paired with manual retraction for the treatment of grade 4-5 phimosis. Successful treatment response may be seen up to 12 weeks.
  • Interventions for infantile seborrhoeic dermatitis (including cradle cap). [Meta-Analysis]
    Cochrane Database Syst Rev 2019; 3:CD011380Victoire A, Magin P, … van Driel ML
  • CONCLUSIONS: Our review identified only a limited number of studies investigating the effects of interventions for ISD in infants and young children. Unlike the reviews investigating the effects of treatments in adults, our results showed that there is uncertainty regarding the effectiveness and safety of studied treatments due to the very low-certainty evidence for all comparisons and outcomes.We assessed most bias domains as at unclear risk, but there was a high risk of bias for (mainly) performance, attrition, and detection bias. Evidence was limited further by imprecision (small studies, low number of events), indirectness (mainly with the outcomes assessed), and poor trial reporting. In most studies, the prognosis for the condition was favourable regardless of intervention but interpretation is limited by the very low-certainty evidence.Further research is needed with large, well-conducted, and well-reported intervention trials, particularly of interventions commonly recommended or used, such as emollients or shampoos and brushing, antifungals, or steroids. All studies should report standardised and validated relevant outcome measures, including adverse events, severity, and QoL, and they should be conducted in primary care settings where the majority of ISD is managed. Future trials should compare against placebo, no treatment, or standard care.
  • Effect of Topical Periocular Steroid Use on Intraocular Pressure: A Retrospective Analysis. [Journal Article]
    Ophthalmic Plast Reconstr Surg 2019 Sep/Oct; 35(5):465-468Maeng MM, De Moraes CG, … Glass LRD
  • CONCLUSIONS: Periocular steroid treatment causes a statistically significant rise in IOP in eyes with higher baseline IOP measurements, the risk of which increases with follow up. While this change is not always correlated with a clinically significant rise in IOP, clinicians should monitor more closely patients at greatest risk of steroid response.
  • Case Report: Acute Generalized Exanthematous Pustulosis Caused by Praziquantel. [Journal Article]
    Am J Trop Med Hyg 2019; 100(3):700-702Shindo T, Masuda Y, … Nishioka H
  • Praziquantel is widely used for treating parasitic infections globally, especially in countries with endemic schistosomiasis. However, severe hypersensitivity to praziquantel has rarely been reported. We report the case of a 30-year-old Japanese man who developed acute generalized exanthematous pustulosis (AGEP), which is a rare and severe cutaneous reaction usually triggered by drugs, after taki…
  • Oral H1 antihistamines as 'add-on' therapy to topical treatment for eczema. [Journal Article]
    Cochrane Database Syst Rev 2019; 1:CD012167Matterne U, Böhmer MM, … Apfelbacher CJ
  • CONCLUSIONS: Based on the main comparisons, we did not find consistent evidence that H1 AH treatments are effective as 'add-on' therapy for eczema when compared to placebo; evidence for this comparison was of low and moderate quality. However, fexofenadine probably leads to a small improvement in patient-assessed pruritus, with probably no significant difference in the amount of treatment used to prevent eczema flares. Cetirizine was no better than placebo in terms of physician-assessed clinical signs nor patient-assessed symptoms, and we found no evidence that loratadine was more beneficial than placebo, although all interventions seem safe.The quality of evidence was limited because of poor study design and imprecise results. Future researchers should clearly define the condition (course and severity) and clearly report their methods, especially participant selection and randomisation; baseline characteristics; and outcomes (based on the Harmonising Outcome Measures in Eczema initiative).
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