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(hydrocortisone topical )
2,571 results
  • A Case of Linear Cutaneous Lupus Erythematosus in a 55-Year-Old Woman. [Journal Article]
    Am J Case Rep. 2020 Mar 16; 21:e921495.Milosavljevic K, Fibeger E, Virata AR
  • CONCLUSIONS: This rare case of LCLE in an older adult showed a similar response to treatment as other forms of cutaneous lupus erythematosus, with treatment that included topical steroids and sun protection. Also, this case supports that environmental trigger factors, such as prior infections, might provide insights into the etiology of LCLE.
  • Anti-inflammatory activity of Anthemis tricolor Boiss. [Journal Article]
    Postepy Dermatol Alergol. 2019 Dec; 36(6):677-680.Demirkan S, Özçınar Ö, Kıvçak B
  • CONCLUSIONS: This is the first report on anti-inflammatory activity of A. tricolor and we showed an anti-inflammatory effect of n-hexane and sesquiterpene extract of A. tricolor with UV erythema test as a result, hence A. tricolor extracts can be used for the treatment of inflammatory skin diseases due to anti-inflammatory activity.
  • Nanoparticle formulations as recrystallization inhibitors in transdermal patches. [Journal Article]
    Int J Pharm. 2020 Feb 15; 575:118886.Tahir MA, Ali ME, Lamprecht A
  • Drug crystallization in transdermal patches is still a major challenge, confronting the formulation development of topical drug delivery systems. Encapsulation of drugs into nanoparticles is proposed here as a promising tool for regulating drug crystallization in transdermal patches. The degree of recrystallization and transdermal permeation of ibuprofen and hydrocortisone loaded in polymeric and…
  • Ocular Pharmacological Profile of Hydrocortisone in Dry Eye Disease. [Journal Article]
    Front Pharmacol. 2019; 10:1240.Bucolo C, Fidilio A, … Drago F
  • To investigate the ocular pharmacological profile of hydrocortisone (HC) using in vitro and in vivo models of dry eye disease. Rabbit corneal epithelial cells (SIRCs) were used to assess the effect of HC in two paradigms of corneal damage: hyperosmotic stress and scratch-wound assay. Dry eye was induced in albino rabbits by topical administration of atropine sulfate or by injection of concanavali…
  • Prescribing Patterns for Atopic Dermatitis in the United States [Journal Article]
    J Drugs Dermatol. 2019 10 01; 18(10):987-990.Pona A, Cline A, … Fleischer AFJ
  • Introduction: Introduction: Although future atopic dermatitis (AD) clinical research is intended to improve standard-of-care treatment, how patients are currently treated is not well characterized. The purpose of this study was to determine the most frequent medications prescribed in all ages of AD. Methods: The National Ambulatory Medical Care Survey (NAMCS) is a nationally representative surve…
  • Diffuse Exfoliative Rash with Sepsis and Eosinophilia: A Case of Erythroderma? [Case Reports]
    Am J Case Rep. 2019 Sep 20; 20:1387-1393.Cho J, Elyaman SA, … Iyamu K
  • CONCLUSIONS: </strong> This case is unique in terms of the rarity of erythroderma and the diagnostic challenge given confounding factors such as noncompliance and drug reaction. Serious causes, such as SLE and cutaneous T cell lymphoma, were ruled out. Fortunately, the rash responded well to steroids; however, given the adverse effects of long-term use of topical steroids, the patient will need follow up with Dermatology.
  • A quality by design approach to develop topical creams via hot-melt extrusion technology. [Journal Article]
    Eur J Pharm Sci. 2019 Aug 01; 136:104948.Mendonsa NS, Pradhan A, … Repka MA
  • The advantages of hot-melt extrusion technology (HME) over conventional techniques to develop topical semisolids have been established. However, this technique is not widely used for semisolid production. Therefore, the aim of this novel work was to develop creams using the melt extrusion technology while applying Quality by Design (QbD) principles to study the effects of the extrusion process pa…
  • Efonidipine-Induced Exanthematic Drug Eruption and Literature Review. [Case Reports]
    J Cardiovasc Pharmacol. 2019 06; 73(6):394-396.Davis S, Raju AR, … Cherian JJ
  • We report the case of an elderly woman who developed exanthematic drug eruption after administration of efonidipine. An 84-year-old woman presented to emergency department with complaints of generalized itching and erythema since 4 days. She was on human-soluble insulin since 11 years. In view of her hypertension and left anterior descending artery stenosis, she was initiated on aspirin, clopidog…
  • Randomized open-label trial comparing topical prescription triamcinolone to over-the-counter hydrocortisone for the treatment of phimosis. [Journal Article]
    J Pediatr Urol. 2019 Aug; 15(4):388.e1-388.e5.Chamberlin JD, Dorgalli C, … Khoury AE
  • CONCLUSIONS: To the study authors' knowledge, this is the first open-label trial with direct comparison of hydrocortisone 1% cream with triamcinolone 0.1% cream. The study results support those reported in other studies when each topical steroid was compared with placebo. Limitations of the study include loss to follow-up, unblinded treatment allocation, and reduced power to detect differences by treatment frequency and duration.Over-the-counter hydrocortisone 1% cream is not inferior to triamcinolone 0.1% cream when paired with manual retraction for the treatment of grade 4-5 phimosis. Successful treatment response may be seen up to 12 weeks.
  • NewBG: A surrogate corticosteroid-binding globulin with an unprecedentedly high ligand release efficacy. [Journal Article]
    J Struct Biol. 2019 08 01; 207(2):169-182.Gardill BR, Schmidt K, Muller YA
  • The introduction of ligand-binding sites into proteins and the engineering of molecular allosteric coupling pathways are topical issues in protein design. Here, we show that these issues can be addressed concurrently, using the serpin human α1-antichymotrypsin (ACT) as a model. We have introduced up to 15 amino acid substitutions into ACT, converting it into a surrogate corticosteroid-binding glo…
  • Interventions for infantile seborrhoeic dermatitis (including cradle cap). [Meta-Analysis]
    Cochrane Database Syst Rev. 2019 03 04; 3:CD011380.Victoire A, Magin P, … van Driel ML
  • CONCLUSIONS: Our review identified only a limited number of studies investigating the effects of interventions for ISD in infants and young children. Unlike the reviews investigating the effects of treatments in adults, our results showed that there is uncertainty regarding the effectiveness and safety of studied treatments due to the very low-certainty evidence for all comparisons and outcomes.We assessed most bias domains as at unclear risk, but there was a high risk of bias for (mainly) performance, attrition, and detection bias. Evidence was limited further by imprecision (small studies, low number of events), indirectness (mainly with the outcomes assessed), and poor trial reporting. In most studies, the prognosis for the condition was favourable regardless of intervention but interpretation is limited by the very low-certainty evidence.Further research is needed with large, well-conducted, and well-reported intervention trials, particularly of interventions commonly recommended or used, such as emollients or shampoos and brushing, antifungals, or steroids. All studies should report standardised and validated relevant outcome measures, including adverse events, severity, and QoL, and they should be conducted in primary care settings where the majority of ISD is managed. Future trials should compare against placebo, no treatment, or standard care.
  • Effect of Topical Periocular Steroid Use on Intraocular Pressure: A Retrospective Analysis. [Journal Article]
    Ophthalmic Plast Reconstr Surg. 2019 Sep/Oct; 35(5):465-468.Maeng MM, De Moraes CG, … Glass LRD
  • CONCLUSIONS: Periocular steroid treatment causes a statistically significant rise in IOP in eyes with higher baseline IOP measurements, the risk of which increases with follow up. While this change is not always correlated with a clinically significant rise in IOP, clinicians should monitor more closely patients at greatest risk of steroid response.
  • Case Report: Acute Generalized Exanthematous Pustulosis Caused by Praziquantel. [Case Reports]
    Am J Trop Med Hyg. 2019 03; 100(3):700-702.Shindo T, Masuda Y, … Nishioka H
  • Praziquantel is widely used for treating parasitic infections globally, especially in countries with endemic schistosomiasis. However, severe hypersensitivity to praziquantel has rarely been reported. We report the case of a 30-year-old Japanese man who developed acute generalized exanthematous pustulosis (AGEP), which is a rare and severe cutaneous reaction usually triggered by drugs, after taki…
  • Oral H1 antihistamines as 'add-on' therapy to topical treatment for eczema. [Journal Article]
    Cochrane Database Syst Rev. 2019 Jan 22; 1:CD012167.Matterne U, Böhmer MM, … Apfelbacher CJ
  • CONCLUSIONS: Based on the main comparisons, we did not find consistent evidence that H1 AH treatments are effective as 'add-on' therapy for eczema when compared to placebo; evidence for this comparison was of low and moderate quality. However, fexofenadine probably leads to a small improvement in patient-assessed pruritus, with probably no significant difference in the amount of treatment used to prevent eczema flares. Cetirizine was no better than placebo in terms of physician-assessed clinical signs nor patient-assessed symptoms, and we found no evidence that loratadine was more beneficial than placebo, although all interventions seem safe.The quality of evidence was limited because of poor study design and imprecise results. Future researchers should clearly define the condition (course and severity) and clearly report their methods, especially participant selection and randomisation; baseline characteristics; and outcomes (based on the Harmonising Outcome Measures in Eczema initiative).
  • Pulp response of rats submitted to bleaching and the use of different anti-inflammatory drugs. [Journal Article]
    PLoS One. 2019; 14(1):e0210338.Gallinari MO, Cintra LTÂ, … Briso ALF
  • This study aimed to evaluate neuropeptide expression after bleaching treatment using histopathological and immunohistochemical analyses and the effects of hydrocortisone and acetaminophen on pulp inflammation, sine dental bleaching and inflammation first occur, and only then, the treatmentt. Sixty-three rats were divided into three groups (n = 21) according to the pain-relieving therapy used: I-c…
  • Topical Anti-Inflammatory and Analgesic Activities of Citrullus colocynthis Extract Cream in Rats. [Journal Article]
    Medicina (Kaunas). 2018 Jul 29; 54(4)Pashmforosh M, Rajabi Vardanjani H, … Khodayar MJ
  • CONCLUSIONS: For the first time, this study indicated that the topical application of CC cream possesses significant anti-inflammatory and antinociceptive activities in animal models, which were probably mediated by opioid receptors and the suppression of pro-inflammatory cytokines (TNF-α and IL-6). Thus, the CC cream can be used to treat inflammatory pain and inflammatory diseases.
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