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1,191 results
  • Assessment of cellular cobalamin metabolism in Gaucher disease. [Journal Article]
    BMC Med Genet 2020; 21(1):12Basgalupp SP, Siebert M, … Schwartz IVD
  • CONCLUSIONS: Our results indicate that cobalamin transport and cellular processing pathways are overall protected from lysosomal storage damage in GD fibroblasts. Extending these studies to hepatocytes, macrophages and plasma will shed light on cell- and compartment-specific vitamin B12 metabolism in Gaucher disease.
  • A Comparison of Potential Azide Antidotes in a Mouse Model. [Journal Article]
    Chem Res Toxicol 2020Frawley KL, Totoni SC, … Peterson J
  • Three cobalt-containing macrocyclic compounds previously shown to antagonize cyanide toxicity have been comparatively evaluated for the amelioration of sub-lethal azide toxicity in juvenile (7-8 weeks) Swiss-Webster mice. The lowest effective doses were determined for hydroxocobalamin, a cobalt porphyrin and a cobalt-Schiff base macrocycle by giving the antidotes 5 min prior to the toxicant, 27 m…
  • Vasoplegia During Cardiopulmonary Bypass: Current Literature and Rescue Therapy Options. [Review]
    J Cardiothorac Vasc Anesth 2019Ortoleva J, Shapeton A, … Dalia AA
  • Vasoplegia syndrome in the cardiac surgical intensive care unit and postoperative period has been an area of interest to clinicians because of its prevalence and effects on morbidity and mortality. However, there is a paucity of evidence regarding the treatment of vasoplegia syndrome during cardiopulmonary bypass (on-CPB VS). This review aims to detail the incidence, outcomes, and possible treatm…
  • Mechanisms of endothelium-dependent vasorelaxation induced by procyanidin B2 in venous bypass graft. [Journal Article]
    J Pharmacol Sci 2019Jankovic G, Marinko M, … Novakovic A
  • Cardioprotective abilities of procyanidins, might, at least in part, attribute to their vasodilator properties. The present study was undertaken to assess the vasorelaxant effect of procyanidin B2 on isolated human saphenous vein (HSV) and its underlying mechanisms. Procyanidin B2 relaxed phenylephrine-induced contraction of HSV rings in concentration-dependent manner. The relaxation was dependen…
  • Intranasal treatment of vitamin B12 deficiency in children. [Journal Article]
    Eur J Pediatr 2019Estourgie-van Burk GF, van der Kuy PHM, … Kneepkens CMF
  • CONCLUSIONS: In children, intranasal application of vitamin B12 seems a safe and effective alternative to intramuscular injections, leading to higher compliance and less burden to patients.What is Known:• Children with vitamin B12deficiency are traditionally treated with intramuscular cobalamin injections, which are costly and painful.• Studies in adults showed that intranasal application of hydroxocobalamin leads to normalisation of vitamin B12levels.What is New:• The intranasal application of vitamin B12resulted in a substantial increase of the mean baseline vitamin B12levels without any side effect.• These data encourage a systematic evaluation of intranasal treatment of vitamin B12deficiency in order to define safety, optimal dosage and administration frequency.
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