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174,232 results
  • Reward sensitivity deficits in a rat model of compulsive eating behavior. [Journal Article]
    Neuropsychopharmacology 2019Moore CF, Leonard MZ, … Cottone P
  • Compulsive eating behavior is hypothesized to be driven in part by reward deficits likely due to neuroadaptations to the mesolimbic dopamine (DA) system. Therefore, the aim of this study was to assess deficits in reward system functioning and mesolimbic DA after alternating a standard chow with palatable diet, a model of compulsive eating. In this model, rats in the control group (Chow/Chow) are …
  • MMOD-induced structural changes of hydroxylase in soluble methane monooxygenase. [Journal Article]
    Sci Adv 2019; 5(10):eaax0059Kim H, An S, … Cho US
  • Soluble methane monooxygenase in methanotrophs converts methane to methanol under ambient conditions. The maximum catalytic activity of hydroxylase (MMOH) is achieved through the interplay of its regulatory protein (MMOB) and reductase. An additional auxiliary protein, MMOD, functions as an inhibitor of MMOH; however, its inhibitory mechanism remains unknown. Here, we report the crystal structure…
  • Enzymatic cascade biosynthesis reaction of musky macrolactones from fatty acids. [Journal Article]
    Enzyme Microb Technol 2019; 131:109417Meng S, Guo J, … Liu L
  • Musky macrolactones are an important group of compounds used in high-valued perfumery. An enzymatic cascade reaction including cytochrome P450 hydroxylase and lipase was explored to biosynthesize musky macrolactones. Firstly, fatty acids were hydroxylated by P450 hydroxylase to produce the corresponding ω-hydroxy fatty acids. Then ω-hydroxy fatty acids were lactonized by lipase. ω-Hydroxy fatty a…
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