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30,646 results
  • Deferasirox-induced liver injury and Fanconi syndrome in a beta-thalassemia major male. [Journal Article]
    BMJ Case Rep. 2020 Jul 09; 13(7)Fraser J, Brook R, … Lewis D
  • A 33-year-old male presenting with subacute abdominal pain was found to have hyperbilirubinaemia, hypokalaemia and hyponatraemia. This was in the setting of transitioning between deferasirox iron chelator formulations, from dispersible tablets to film-coated tablets for ongoing treatment of chronic iron overload secondary to transfusion requirement for beta-thalassemia major. A liver biopsy demon…
  • [Unusual serum protein electrophoresis in a patient with cholangiocarcinoma]. [Case Reports]
    Pan Afr Med J. 2020; 35:117.Bissan ADT, Diawara A, … Algiman E
  • Serum protein electrophoresis is of certain diagnostic interest. We report a case of unusual electrophoresis associated with cholestatic jaundice complicating a cholangiocarcinoma. The study involved a 55-year old patient hospitalized for the exploration of cholestatic jaundice. Capillary electrophoresis showed bisalbuminemia diagnosed based on the thickening of the bottom of the albumin peak and…
  • Large scale validation of a new non-invasive and non-contact bilirubinometer in neonates with risk factors. [Journal Article]
    Sci Rep. 2020 Jul 07; 10(1):11149.Halder A, Adhikari A, … Pal SK
  • The study was aimed to evaluate the performance of a newly developed non-invasive and non-contact bilirubin measurement device (AJO-Neo) as an alternative to the conventional invasive biochemical method of total serum bilirubin (TSB) estimation in preterm and term neonates suffering from hyperbilirubinemia associated with risk factors, and/or undergoing phototherapy. The safety and efficacy of th…
  • COVID-19 associated Kawasaki-like multisystem inflammatory disease in an adult. [Case Reports]
    Am J Emerg Med. 2020 Jun 25 [Online ahead of print]Sokolovsky S, Soni P, … Scheers-Masters J
  • Recent reports have described a secondary Multisystem Inflammatory Syndrome in Children (MIS-C) after a prior COVID-19 infection that often has features of Kawasaki disease (KD). Here, we report the case of a 36-year-old woman who presented to the emergency department hypotensive and tachycardic after 1 week of fevers, abdominal pain, vomiting and diarrhea, and was found to have the classic pheno…
  • Combating the Hidden Health Disparity of Kernicterus in Black Infants: A Review. [Journal Article]
    JAMA Pediatr. 2020 Jul 06 [Online ahead of print]Okolie F, South-Paul JE, Watchko JF
  • CONCLUSIONS: There are multiple opportunities for intervention to reduce black kernicterus risk. Although kernicterus is a rare disorder, the incidence among black infants is not a trivial matter nor are efforts to prevent kernicterus. While the multiple interacting biologic and nonbiologic contributors to increased kernicterus risk among black infants pose a considerable challenge to clinicians, there are opportunities for intervention to reduce this risk and health disparity. Continued study is imperative to understand the current scope of kernicterus and its occurrence in black neonates.
  • Hemolytic Anemia: Sneaky Cause, Leaky Valve. [Case Reports]
    Cureus. 2020 May 31; 12(5):e8370.Rai M, Ali MU, Geller C
  • Intravascular hemolysis is a known complication of prosthetic heart valves. Severe hemolysis is rare (<1%) with the use of newer generation prosthetic valves. This usually occurs due to paravalvular leaks (PVLs). We present a case of hyperbilirubinemia and hemolytic anemia occurring as a result of a PVL of a prosthetic mechanical mitral valve. The patient was a 49-year-old female with a past medi…
  • Effect of delayed cord clamping on stem cell transfusion and hematological parameters in preterm infants with placental insufficiency: a pilot randomized trial. [Journal Article]
    Eur J Pediatr. 2020 Jul 04 [Online ahead of print]Yunis M, Nour I, … Nasef N
  • CONCLUSIONS: In conclusion, DCC compared with ICC increased stem cell transfusion and decreased early- and late-onset anemia in preterm infants with placental insufficiency.Trial registration: NCT03731546 What is Known: • Delayed cord clamping has been recommended by the American Academy of Pediatrics as a standard of care practice during delivery of preterm infants. • The feasibility of DCC in preterm infants with placental insufficiency (PI) is uncertain. What is New: • This randomized controlled trial demonstrated that DCC in the delivery room care of preterm infants born to mothers with placental insufficiency increased stem cell transfusion and decreased early- and late-onset anemia.
  • Bilirubin in metabolic syndrome and associated inflammatory diseases: New perspectives. [Review]
    Life Sci. 2020 Jul 01; 257:118032.Novák P, Jackson AO, … Yin K
  • Diabetes mellitus is one of the major global health issues, which is closely related to metabolic dysfunction and the chronic inflammatory diseases. Multiple studies have demonstrated that serum bilirubin is negatively correlated with metabolic syndrome and associated inflammatory diseases, including atherosclerosis, hypertension, etc. However, the roles of bilirubin in metabolic syndrome and ass…
  • Lyme Disease and Severe Hyperbilirubinemia: A Rare Presentation of Lyme Disease. [Case Reports]
    Cureus. 2020 May 30; 12(5):e8363.Ahmed Z, Ur Rehman A, … Ahmad S
  • A 39-year-old-man presented to the emergency room with a complaint of febrile jaundice and diffuse arthralgia. The patient had a temperature of 100°F, severe jaundice, and scleral icterus. Laboratory workup showed severe hyperbilirubinemia and elevated serum creatinine, and the rest of the serum chemistry was unremarkable. The ultrasound and computed tomography (CT) of the abdomen was normal. The…
  • Use of reflective materials during phototherapy for newborn infants with unconjugated hyperbilirubinaemia. [Review]
    Cochrane Database Syst Rev. 2020 Jul 01; 7:CD012011.Van Rostenberghe H, Ho JJ, … Abd Hamid IJ
  • CONCLUSIONS: Moderate-certainty evidence shows that the use of reflective curtains during phototherapy may result in greater decline in SB. Very low-certainty evidence suggests that the duration of phototherapy is reduced, and moderate-certainty evidence shows that the duration of hospital stay is also reduced. Available evidence does not show any increase in adverse events, but further studies are needed.
  • Rh Alloimmunisation: Current Updates in Antenatal and Postnatal Management. [Review]
    Indian J Pediatr. 2020 Jul 01 [Online ahead of print]Sahoo T, Sahoo M, … Gupta M
  • In spite of advances in medical science, Rh alloimmunisation remains one of the leading causes of preventable neuro-morbidities and significant neonatal hyperbilirubinemia in lower-middle income countries. Despite availability of effective antenatal preventive strategy (Anti-D), its uptake in antenatal period is low due to ignorance. Further, once diagnosed, there is lack of adequate antenatal fo…
  • ​False-positive paracetamol levels in a patient with hyperbilirubinaemia: clinical perspectives. [Journal Article]
    BMJ Case Rep. 2020 Jun 30; 13(6)James J, Stauss M, … Myers M
  • ​Serum concentrations of paracetamol are measured to investigate the cause of acute hepatitis, monitor the clearance of paracetamol from the body and to determine if supratherapeutic levels warrant treatment with N-acetylcysteine (NAC). ​A 49-year-old man treated for ischaemic colitis developed worsening renal and liver function tests. As part of the investigation of hepatorenal failure, paraceta…
  • Preliminary study of Cytauxzoon felis infection in outdoor cats in Mashhad, Iran. [Journal Article]
    Parasitol Res. 2020 Jun 25 [Online ahead of print]Rahmati Moghaddam M, Zaeemi M, Razmi GR
  • The objectives of the current study were to assess the preliminary status of Cytauxzoon felis (C. felis) infection among outdoor cats in Mashhad, Iran and also to compare clinicopathological findings between C. felis infected and non-infected cats. Blood samples were collected from 100 outdoor domestic cats between April and September in 2019. Infection with C. felis was determined using microsco…
  • Effect of Phototherapy on Peripheral Blood Cells in Hyperbilirubinemic Newborns. [Journal Article]
    J Coll Physicians Surg Pak. 2020 May; 30(5):547-549.Kurt A, Tosun MS, … Erol S
  • This study was conducted to determine the neutrophil/lymphocyte ratio, lymphocyte/monocyte ratio, platelet/lymphocyte ratio; and to evaluate the effect of phototherapy on the peripheral blood cells in newborns with indirect hyperbilirubinemia. A total of 180 newborns consisting of 119 hyperbilirubinemic newborns, who received phototherapy; and 61 healthy newborns were included in the study. A sta…
  • Probiotic treatment for women with gestational diabetes to improve maternal and infant health and well-being. [Review]
    Cochrane Database Syst Rev. 2020 06 24; 6:CD012970.Okesene-Gafa KA, Moore AE, … Crowther CA
  • CONCLUSIONS: Low-certainty evidence means we are not certain if there is any difference between probiotic and placebo groups in maternal hypertensive disorders of pregnancy, caesareans; and large-for-gestational-age babies. There were no adverse events reported by the trials. Due to the variability of probiotics used and small sample sizes of trials, evidence from this review has limited ability to inform practice. Well-designed adequately-powered trials are needed to identify whether probiotics may improve maternal blood glucose levels and/or infant/child/adult outcomes; and whether they can be used to treat GDM.
  • [Russian consensus on current issues in the diagnosis and treatment of obstructive jaundice syndrome]. [Journal Article]
    Khirurgiia (Mosk). 2020Khatkov IE, Avanesyan RG, … Kulezneva YV
  • The Russian consensus document on topical issues of the diagnosis and treatment of obstructive jaundice syndrome was prepared by a group of experts in various fields of surgery, endoscopy, interventional radiology, radiological diagnosis and intensive care. The goal of this document is to clarify and consolidate the opinions of national experts on the following issues: timing of diagnosis of obst…
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