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4,095 results
  • FGF23 and Associated Disorders of Phosphate Wasting. [Journal Article]
    Pediatr Endocrinol Rev 2019; 17(1):17-34Gohil A, Imel EA
  • Fibroblast growth factor 23 (FGF23), one of the endocrine fibroblast growth factors, is a principal regulator in the maintenance of serum phosphorus concentration. Binding to its cofactor αKlotho and a fibroblast growth factor receptor is essential for its activity. Its regulation and interaction with other factors in the bone-parathyroid-kidney axis is complex. FGF23 reduces serum phosphorus con…
  • Regimens of vitamin D supplementation for women during pregnancy. [Review]
    Cochrane Database Syst Rev 2019; 10:CD013446Palacios C, Trak-Fellermeier MA, … Peña-Rosas JP
  • CONCLUSIONS: Supplementing pregnant women with more than the current vitamin D recommendation may reduce the risk of gestational diabetes; however, it may make little or no difference to the risk of pre-eclampsia, preterm birth and low birthweight. Supplementing pregnant women with more than the current upper limit for vitamin D seems not to increase the risk of the outcomes evaluated. In general, the GRADE was considered low certainty for most of the primary outcomes due to serious risk of bias and imprecision of results. With respect to safety, it appears that vitamin D supplementation is a safe intervention during pregnancy, although the parameters used to determine this were either not reported or not consistent between trials. Future trials should be consistent in their reports of adverse events. There are 16 ongoing trials that when published, will increase the body of knowledge.
  • Antenatal Bartter Syndrome Caused by a Novel Homozygous Mutation in SLC12A1 Gene. [Case Reports]
    Indian J Nephrol 2019 Sep-Oct; 29(5):360-363Acar FA, Işik G, … Kalyoncu M
  • Antenatal Bartter syndrome (BS) is an autosomal recessive hereditary renal tubular disorder caused by mutation in the solute carrier family 12 member 1 (SLC12A1) gene on chromosome 15q21.1. This syndrome is characterized by polyuria, hyponatremia, hypokalemic hypochloremic metabolic alkalosis, and hypercalciuria associated with increased urinary loss of electrolytes. Herein, we report a very low-…
  • Pre-, post- or no acidification of urine samples for calcium analysis: does it matter? [Journal Article]
    Clin Chem Lab Med 2019Chenevier-Gobeaux C, Rogier M, … Borderie D
  • Background Measuring 24 h-urine calcium concentration is essential to evaluate calcium metabolism and excretion. Manufacturers recommend acidifying the urine before a measurement to ensure calcium solubility, but the literature offers controversial information on this pre-analytical treatment. The objectives of the study were (1) to compare pre-acidification (during urine collection) versus post-…
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