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1,161 results
  • Sodium Intake and Chronic Kidney Disease. [Review]
    Int J Mol Sci. 2020 Jul 03; 21(13)Borrelli S, Provenzano M, … Andreucci M
  • In Chronic Kidney Disease (CKD) patients, elevated blood pressure (BP) is a frequent finding and is traditionally considered a direct consequence of their sodium sensitivity. Indeed, sodium and fluid retention, causing hypervolemia, leads to the development of hypertension in CKD. On the other hand, in non-dialysis CKD patients, salt restriction reduces BP levels and enhances anti-proteinuric eff…
  • Point-of-care ultrasound to evaluate volume status in severe hyponatremia. [Journal Article]
    BMJ Case Rep. 2020 Jun 28; 13(6)Evins C, Rao A
  • A 51-year-old man was hospitalised for severe hyponatremia. Initial history and physical examination suggested hypovolemia, and he was treated with normal saline at 100 mL/hour. After several days, his hyponatremia failed to improve, and then worsened without resolution of presenting ataxia and fatigue. He had no new complaints including no cough or orthopnea. He had no jugular venous distention …
  • Ouabain and Marinobufagenin: Physiological Effects on Human Epithelial and Endothelial Cells. [Journal Article]
    Biochemistry (Mosc). 2020 Apr; 85(4):507-515.Klimanova EA, Fedorov DA, … Orlov SN
  • Long-term study on the identification of Na,K-ATPase endogenous inhibitors in mammalian tissues has resulted in the discovery of ouabain, marinobufagenin (MBG), and other cardiotonic steroids (CTS) in the blood plasma. Production of ouabain and MBG is increased in essential hypertension and other diseases associated with hypervolemia. Here, we compared the effects of ouabain and MBG on the Na,K-A…
  • Hydration status and blood pressure variability in primary hypertensive patients. [Journal Article]
    Nefrologia. 2020 Jun 11 [Online ahead of print]Dizdar OS, Yeşiltepe A, … Gunal AI
  • CONCLUSIONS: Addition of diuretic to established treatment or intensified diuretic treatment and keeping patients in negative hydration status resulted in reduction in BPV at twelfth month of follow-up. More weight gain and higher systolic BP are major risk factors of high systolic ARV, but not hypervolemia. BPV, especially diastolic ARV, was significantly associated with TOD.
  • NSAIDs in CKD: Are They Safe? [Review]
    Am J Kidney Dis. 2020 May 29 [Online ahead of print]Baker M, Perazella MA
  • The management of pain in patients with chronic kidney disease (CKD) is challenging for many reasons. These patients have an increased susceptibility to adverse drug effects due to altered drug metabolism and excretion, and there are limited safety data for use in this population despite a high pain burden. Non-steroidal anti-inflammatory drugs (NSAIDs) have long been regarded as dangerous for us…
  • Management of extracellular volume in patients with end-stage kidney disease and severe hyperglycemia. [Journal Article]
    J Diabetes Complications. 2020 May 03 [Online ahead of print]Roumelioti ME, Sun Y, … Tzamaloukas AH
  • This commentary addresses volume replacement in hyperglycemic crises in patients with end-stage kidney disease (ESKD). The management of volume issues in this group of patients should not be based on guidelines for management of hyperglycemic crises, but should be individualized and based on directed patient medical history, physical examination, and imaging of the heart and lungs. A scheme for c…
  • Can goal-directed fluid therapy decrease the use of blood and hemoderivates in surgical patients? [Journal Article]
    Minerva Anestesiol. 2020 Apr 06 [Online ahead of print]Tomescu DR, Scarlatescu E, Bubenek-Turconi ŞI
  • The purpose of Goal Directed Therapy (GDT) is to improve patient outcome by the optimization of hemodynamic status, as it is considered that many perioperative complications are related to microcirculatory disturbance due to an imbalance between oxygen delivery and consumption. The application of GDT protocols incorporating the assessment and optimization of patients' intravascular status should …
  • Fetal cardiovascular alterations in twin-to-twin transfusion syndrome. [Review]
    Med Pharm Rep. 2020 Jan; 93(1):5-11.Rotar IC, Zaharie G, … Mureşan D
  • Twin-to-twin transfusion syndrome (TTTS) is the consequence of vascular anastomoses of the shared placenta of monochorionic twin pregnancies. Both circulating inter-twin blood flow and vasoactive mediators imbalance cause hypovolemia in the donor and hypervolemia in the recipient fetus. If left untreated, TTTS has a high perinatal mortality rate and adverse long-term outcomes mainly cardiovascula…
  • Intravascular volumes evaluated by a carbon monoxide rebreathing method in patients undergoing chronic hemodialysis. [Journal Article]
    Hemodial Int. 2020 Apr; 24(2):252-260.Bomholt T, Larsson S, … Lundby C
  • CONCLUSIONS: The CO rebreathing test is a new approach to measuring intravascular volumes in hemodialysis patients. Compared with predicted intravascular volumes, the predialysis BV was expanded in the majority with elevated PV as the main cause. No overall difference in RBCV was found between the measured and predicted volumes. According to predialysis Hb levels, all but one patient was anemic, but according to the measured RBCV, only nine were in the anemic range, indicating dilution of Hb.
  • [Perioperative fluid management]. [Review]
    Chirurg. 2020 Feb; 91(2):121-127.Wellge BE, Trepte CJ, … Bockhorn M
  • An appropriate perioperative infusion management is pivotal for the perioperative outcome of the patient. Optimization of the perioperative fluid treatment often results in enhanced postoperative outcome, reduced perioperative complications and shortened hospitalization. Hypovolemia as well as hypervolemia can lead to an increased rate of perioperative complications. The main goal is to maintain …
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