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4,105 results
  • The Role of Hypothalamic Pathology for Non-Motor Features of Huntington's Disease. [Journal Article]
    J Huntingtons Dis 2019Cheong RY, Gabery S, Petersén Å
  • Huntington's disease (HD) is a fatal genetic neurodegenerative disorder. It has mainly been considered a movement disorder with cognitive symptoms and these features have been associated with pathology of the striatum and cerebral cortex. Importantly, individuals with the mutant huntingtin gene suffer from a spectrum of non-motor features often decades before the motor disorder manifests. These s…
  • Differential Roles of Each Orexin Receptor Signaling in Obesity. [Journal Article]
    iScience 2019; 20:1-13Kakizaki M, Tsuneoka Y, … Funato H
  • Orexins are hypothalamic neuropeptides that regulate feeding, energy expenditure, and sleep. Although orexin-deficient mice are susceptible to obesity, little is known about the roles of the orexin receptors in long-term energy metabolism. Here, we performed the metabolic characterization of orexin receptor-deficient mice. Ox1r-deficient mice were resistant to diet-induced obesity, and their food…
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