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1,461 results
  • StatPearls: Physiology, Opioid Receptor [BOOK]
    StatPearls Publishing: Treasure Island (FL) Dhaliwal Armaan A Gupta Mohit M Cleveland Clinic Foundation BOOK
  • The utilization of opioids in clinical pharmacology started after the extraction of morphine from the opium poppy Papaver somniferum in 1806 with its use further intensified after the discovery of hypodermic needles in 1853.[1] Opioids divide into two types, those being endogenous and exogenous. Some endogenous opioids that bind to the receptors are enkephalins, endorphins, endomorphins, dynorphi…
  • Penile calciphyilaxis treated with daily Tadalafil: Case report. [Case Reports]
    Urol Case Rep 2019; 26:100960Moya CC, Huerta AS, Sarrat IS
  • Calciphylaxis is a rare vascular disorder, characterized by a progresive systemic calcification of dermo-hypodermic arterioles. We present a case of end-stage renal disease (ESRD) patient on Hemodialysis, with calciphyilaxis, whose clinical manifestation were ulcerated lesions on the penis, treated with phosphodiesterae-5 (PDE5) inhibitors, with good clinical response.
  • A miniaturized device for biomembrane permeation analysis. [Journal Article]
    Mater Sci Eng C Mater Biol Appl 2019; 103:109772Ding D, Pan J, … Kang L
  • Transdermal drug delivery is widely investigated as an alternative drug administration route to oral delivery and hypodermic injections. Owing to the availability of human skin samples, in vitro tests are used to predict the in vivo delivery of transdermal drugs. The most widely used validation method is skin permeation using diffusion cells. Traditional diffusion cells, however, are capacious an…
  • An Injectable System for Subcutaneous Photoplethysmography, Accelerometry, and Thermometry in Animals. [Journal Article]
    IEEE Trans Biomed Circuits Syst 2019Reynolds J, Ahmmed P, Bozkurt A
  • Obtaining physiological data from animals in a non-obtrusive and continuous manner is important to veterinary science. This paper demonstrates the design and deployment of a miniaturized capsule-based system for subdermal injection to provide real-time and continuous heart-rate, movement, and core-body-temperature measurements. The presented device incorporates sensors for photoplethysmography, m…
  • Subcutaneous nicotine delivery via needle-free jet injection: A porcine model. [Journal Article]
    J Control Release 2019; 306:83-88Ruddy BP, Bullen C, … Taberner AJ
  • Subcutaneous delivery of nicotine was performed using a novel electrically-operated needle-free jet injector, and compared to hypodermic needle delivery in a porcine model. Nicotine was delivered as a single, one-milligram dose into the abdominal skin, formulated as a 50 microliter aqueous solution. Plasma levels of nicotine and cotinine, its main metabolite, were then monitored over 2 h, followi…
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