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465,481 results
  • A 4-D approach for amelioration of periodontitis. [Journal Article]
    Med Hypotheses 2019; 133:109392Jain P, Mirza MA, Iqbal Z
  • Global prevalence of the severe periodontitis is at the alarming stage and its association with the systemic complications is highly evident which cannot be neglected. An insight into the pathophysiology of the periodontitis reveals that the promising amelioration could only be envisaged with the 4-D/multi-pronged approach of combining antibiotic along with the host modulating agents. The complic…
  • Optimality in the standard genetic code is robust with respect to comparison code sets. [Journal Article]
    Biosystems 2019; 185:104023Wichmann S, Ardern Z
  • The genetic code and its evolution have been studied by many different approaches. One approach is to compare the properties of the standard genetic code (SGC) to theoretical alternative codes in order to determine how optimal it is and from this infer whether or not it is likely that it has undergone a selective evolutionary process. Many different properties have been studied in this way in the…
  • JAK inhibitors for the treatment of autoimmune and inflammatory diseases. [Review]
    Autoimmun Rev 2019; :102390Jamilloux Y, El Jammal T, … Sève P
  • Cytokines play a central role in the pathophysiology of autoimmune and inflammatory diseases. Several cytokines signal through the JAK-STAT pathway, which is now recognized as a major target to inhibit the effect of a wide array of cytokines. JAK inhibitors are increasingly used in the setting of inflammatory and autoimmune diseases. While the currently approved drugs are panJAK inhibitors, more …
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