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152,600 results
  • Extremely Preterm Born Infants and Long-term Neurodevelopmental Outcomes. [Letter]
    Acta Paediatr 2019Briana DD, Malamitsi-Puchner A
  • In their exemplary study, Zaigham et al evaluated the association between intrapartum hypoxia in extremely preterm infants (born from 22 to 26 weeks of gestation) and risk of death or neurodevelopmental sequelae in later life.1 Of the 705 infants born alive, 492 (70%) survived to up to 1 year of corrected age and a further 8 children died between 1 and 6.5 years of corrected age.1 Another 43 chil…
  • TBK1 is a Synthetic Lethal Target in Cancer with VHL Loss. [Journal Article]
    Cancer Discov 2019Hu L, Xie H, … Zhang Q
  • TANK Binding Kinase 1 (TBK1) is an important kinase involved in innate immune response. Here we discover that TBK1 is hyperactivated by von Hippel-Lindau (VHL) loss or hypoxia in cancer cells. Tumors from kidney cancer patients with VHL loss display elevated TBK1 phosphorylation. Loss of TBK1 via genetic ablation, pharmacological inhibition, or a new Cereblon-based proteolysis targeting chimera (…
  • Comparative transcriptomics reveals PrrAB-mediated control of metabolic, respiration, energy-generating, and dormancy pathways in Mycobacterium smegmatis. [Journal Article]
    BMC Genomics 2019; 20(1):942Maarsingh JD, Yang S, … Haydel SE
  • CONCLUSIONS: The M. smegmatis PrrAB two-component system regulates respiratory and oxidative phosphorylation pathways, potentially to provide tolerance against the dynamic environmental conditions experienced in its natural ecological niche. PrrAB positively regulates ATP levels during exponential growth, presumably through transcriptional activation of both terminal respiratory branches (cytochrome c bc1-aa3 and cytochrome bd oxidases), despite transcriptional repression of ATP synthase genes. Additionally, PrrAB positively regulates expression of the dormancy-associated dosR response regulator genes in an oxygen-independent manner, which may serve to fine-tune sensory perception of environmental stimuli associated with metabolic repression.
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