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14,944 results
  • Development of NSAID-loaded nano-composite scaffolds for skin tissue engineering applications. [Journal Article]
    J Biomed Mater Res B Appl Biomater. 2020 Jul 03 [Online ahead of print]Zehra M, Mehmood A, … Riazuddin S
  • Scar free healing together with pain management is one of the major considerations in full thickness wound healing. Extensive wounds take longer to heal without any clinical intervention and, hence, need natural or artificial extracellular matrix support for quick skin regeneration. To address these issues, medicated 3D porous biomimetic scaffolds were developed with a unique combination of biopo…
  • Anti-Sporothrix activity of ibuprofen combined with antifungal. [Journal Article]
    Braz J Microbiol. 2020 Jul 02 [Online ahead of print]Borba-Santos LP, Nucci M, … Rozental S
  • The in vitro activity of ibuprofen, a nonsteroidal anti-inflammatory drug, was evaluated against Sporothrix brasiliensis and S. schenckii, either alone or in combination with amphotericin B, itraconazole, or terbinafine. The inhibitory activity of ibuprofen as a single agent was determined according to minimum inhibitory concentration (MIC) values, while the effect of ibuprofen combined with amph…
  • The effectiveness of an oral opioid rescue medication algorithm for postoperative pain management compared to PCIA : A cohort analysis. [Journal Article]
    Anaesthesist. 2020 Jul 02 [Online ahead of print]Erlenwein J, Emons MI, … Przemeck M
  • CONCLUSIONS: In this study PCIA provided a better reduction of pain intensity, when compared to a standardized protocol with oral opioid rescue medication. This effect was associated with increased opioid consumption. There were no differences in frequencies of opioid side effects. This study was a retrospective analysis of two cohorts of a major project. As with all retrospective studies, our analysis has several limitations to consider. Data can only represent the observation of clinical practice. It cannot reflect the quality of a statement of a randomized controlled trial. Observational studies do not permit conclusions on causal relationships.
  • Monitoring pharmaceuticals and personal care products in water and fish from the Gulf of Urabá, Colombia. [Journal Article]
    Heliyon. 2020 Jun; 6(6):e04215.Pemberthy M D, Padilla Y, … Peñuela GA
  • Gulf of Urabá is considered a tourist zone of Antioquia Department attracts a large number of visitors to explore the aquatic ecosystem and beaches thus offering a large economic benefit. However, this region has been affected by various anthropogenic effects thus generating an environmental problematic that affect aquatic ecosystem. Over the years, several research has been evaluated pollutant s…
  • [Temporal and Spatial Occurrence of NSAIDs in Taihu Lake and Relevant Risk Assessment]. [Journal Article]
    Huan Jing Ke Xue. 2020 May 08; 41(5):2229-2238.Lian J, Li YF, … Shi HX
  • Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of drug residues with a high frequency of detection in Taihu Lake. However, little information is available about the occurrence of typical NSAID mixtures in Taihu Lake as a whole across the four seasons. Therefore, for each season, the concentrations of five typical NSAIDs including diclofenac, ibuprofen, indomethacin, naproxen, and keto…
  • Negative predictive value of provocation tests for nonsteroidal anti-inflammatory drugs in children. [Journal Article]
    Allergy Asthma Proc. 2020 Jul 01; 41(4):285-289.Topal OY, Ilknur KC, … Emine DM
  • Background: After antibiotics, nonsteroidal anti-inflammatory drugs (NSAID) are one of the leading drug classes responsible for hypersensitivity reactions in children. The drug provocation test (DPT) is the criterion standard for diagnosis. Objective: The aim of the present study was to determine the negative predictive values (NPV) of DPTs with NSAIDs in pediatric patients and to evaluate thei…
  • Ibuprofen versus acetazolamide for prevention of acute mountain sickness. [Journal Article]
    Medwave. 2020 Jun 11; 20(5):e7733.Schilling M, Irarrázaval S
  • CONCLUSIONS: We identified two systematic reviews that included only one primary study, which is a randomized trial. We concluded it is not possible to establish whether ibuprofen is better or worse than acetazolamide because the certainty of evidence has been evaluated as very low.
  • Lip Synechia Resulting From Toxic Epidermal Necrolysis, a Rare Condition. [Journal Article]
    J Craniofac Surg. 2020 Jun 24 [Online ahead of print]Mendes BC, Santos AMS, … Bonardi JP
  • Toxic epidermal necrolyses represent a severe epidermolytic reaction characterized by cutaneous erythema and target lesions affecting >30% of the body surface, skin, and mucous membranes. Ulcerative lesions on the labial mucosa may evolve during healing, resulting in rare complications, such as lip adhesions. This report shows the successful treatment of a lip synechia resulting from the healing …
  • Chiral bioanalytical methods in bioequivalence studies of intravenous vs. oral formulations of ibuprofen. [Journal Article]
    Chirality. 2020 Jun 29 [Online ahead of print]González-Rojano E, Marcotegui J, … García-Arieta A
  • According to the Ibuprofen Product-Specific Bioequivalence Guidance of the European Medicines Agency, achiral bioanalytical methods are considered acceptable for demonstration of bioequivalence of ibuprofen-containing products. The aim of this investigation is to compare the bioequivalence outcomes obtained with individual R and S ibuprofen enantiomers and the sum of both enantiomers from bioequi…
  • Novel Cleaning-in-Place Strategies for Pharmaceutical Hot Melt Extrusion. [Journal Article]
    Pharmaceutics. 2020 Jun 24; 12(6)Spoerk M, Koutsamanis I, … Paudel A
  • To avoid any type of cross-contamination, residue-free production equipment is of utmost importance in the pharmaceutical industry. The equipment cleaning for continuous processes such as hot melt extrusion (HME), which has recently gained popularity in pharmaceutical applications, necessitates extensive manual labour and costs. The present work tackles the HME cleaning issue by investigating two…
  • Inkjet printing of a thermolabile model drug onto FDM-printed substrates: formulation and evaluation. [Journal Article]
    Drug Dev Ind Pharm. 2020 Jul 01 [Online ahead of print]Eleftheriadis GK, Katsiotis CS, … Fatouros DG
  • Objective: The inkjet printing (IP) and fused deposition modeling (FDM) technologies have emerged in the pharmaceutical field as novel and personalized formulation approaches. Specific manufacturing factors must be considered in each adopted methodology, i.e. the development of suitable substrates for IP and the incorporation of highly thermostable active pharmaceutical compounds (APIs) for FDM.…
  • Solid-state interaction of ibuprofen with magnesium stearate and product characterization thereof. [Journal Article]
    Drug Dev Ind Pharm. 2020 Jun 28 [Online ahead of print]Stojanovska Pecova M, Geskovski N, … Makreski P
  • Solid-state compatibility of API with excipients is essential step in the preformulation stage of early development of new finished dosage form. Thermal analysis and vibrational spectroscopy are complementary techniques that play pivotal role to assess the solid-state compatibility of API with excipients. Their coupling and combination with multivariate analysis, provide valuable quantitative asp…
  • Clinical Characteristics and Disease Progression in Early-Stage COVID-19 Patients in South Korea. [Journal Article]
    J Clin Med. 2020 Jun 23; 9(6)Choi MH, Ahn H, … Jeong SH
  • A rapid increase in the number of patients with coronavirus disease 19 (COVID-19) may overwhelm the available medical resources. We aimed to evaluate risk factors for disease severity in the early stages of COVID-19. The cohort comprised 293 patients with COVID-19 from 5 March 2020, to 18 March 2020. The Korea Centers for Disease Control and Prevention (KCDC) classification system was used to tri…
  • Demonstration of a feasible energy-water-environment nexus: waste sulfur dioxide for water treatment. [Journal Article]
    Appl Energy. 2019 Sep 15; 250:1011-1022.Chen L, Xu G, … Alshawabkeh AN
  • Sulfur dioxide (SO2) mitigation and water treatment are two key aspects towards a sustainable environment, and simultaneous achievement of these two goals is extremely attractive. Inspired by the iron ion catalyzed auto-oxidation of aqueous SO2 (i.e., Fe(II)/sulfite process), that generates intermediary sulfate radical able to oxidize organic compounds, we propose a feasible energy-water-environm…
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