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14,261 results
  • Glucocorticoids increase renal excretion of urate in mice by down-regulating urate transporter 1. [Journal Article]
    Drug Metab Dispos 2019Li G, Han L, … Zhang Y
  • Both non-steroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids have been widely used for the treatment of gout, a disease promoted by excess body burden of uric acid (UA). However, their effects on the homeostasis of UA remain poorly understood. The present study showed that 1-week treatments with three NSAIDs (ibuprofen, diclofenac and indomethacin) had little effect on UA homeostasis i…
  • Model-based approach to the design of pharmaceutical roller-compaction processes. [Journal Article]
    Int J Pharm X 2019; 1:100005Toson P, Lopes DG, … Khinast J
  • This work presents a new model based approach to process design and scale-up within the same equipment of a roller compaction process. The prediction of the operating space is not performed fully in-silico, but uses low-throughput experiments as input. This low-throughput data is utilized in an iterative calibration routine to describe the behavior of the powder in the roller compactor and improv…
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