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247 results
  • Alcohol's Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status. [Journal Article]
    Alcohol Clin Exp Res 2019Saini N, Helfrich KK, … Smith SM
  • CONCLUSIONS: These findings suggest that alcohol-driven stimulation of the IL-6/JAK2/STAT3 pathway mediates the elevated hepcidin observed in the PAE dam and fetus. Normalization of these signals by IF suggests that dysregulated hepcidin is driven by alcohol's disruption of the IL-6/JAK2/STAT3 pathway. Prenatal dietary IF represents a potential therapeutic approach for PAE that warrants further investigation.
  • Eimeria tenella: specific EtAMA1-binding peptides inhibit sporozoite entry into host cells. [Journal Article]
    Poult Sci 2019; 98(10):4480-4491Ma D, Huang Y, … Dalloul RA
  • Avian coccidiosis caused by Eimeria inflicts high economic losses to the poultry industry. Application of drugs and live vaccines presents particular challenges in pathogen resistance and cost, hence alternative anti-coccidial strategies are needed. In this study, peptides that specifically bind E. tenella AMA1 (EtAMA1) were screened from a phage display peptide library. The positive clones of ta…
  • CFM-ID 3.0: Significantly Improved ESI-MS/MS Prediction and Compound Identification. [Journal Article]
    Metabolites 2019; 9(4)Djoumbou-Feunang Y, Pon A, … Wishart DS
  • Metabolite identification for untargeted metabolomics is often hampered by the lack of experimentally collected reference spectra from tandem mass spectrometry (MS/MS). To circumvent this problem, Competitive Fragmentation Modeling-ID (CFM-ID) was developed to accurately predict electrospray ionization-MS/MS (ESI-MS/MS) spectra from chemical structures and to aid in compound identification via MS…
  • Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland. [Journal Article]
    Nat Commun 2019; 10(1):410Kurki MI, Saarentaus E, … Palotie A
  • The contribution of de novo variants in severe intellectual disability (ID) has been extensively studied whereas the genetics of mild ID has been less characterized. To elucidate the genetics of milder ID we studied 442 ID patients enriched for mild ID (>50%) from a population isolate of Finland. Using exome sequencing, we show that rare damaging variants in known ID genes are observed significan…
  • Si-Bridged Ladder-Type Small-Molecule Acceptors for High-Performance Organic Photovoltaics. [Journal Article]
    ACS Appl Mater Interfaces 2019; 11(1):1125-1134Wang CK, Jiang BH, … Wong KT
  • In this study, we synthesized 5,11-dihexyl-4,4,10,10-tetraoctylbenzo[1,2- b:4,5- b']bisthieno[4″,5″- b″:4‴,5‴- b‴]silolo[2″,3″- d:2‴,3‴- d']thiophene (ArSi) as a ladder-type electron-rich core for the preparation of three acceptor-donor-acceptor-type nonfullerene acceptors (NFAs)-ArSiID, ArSiID-F, and ArSiID-Cl-featuring (3-oxo-2,3-dihydro-1 H-inden-1-ylidene)malononitrile (ID), 2-(5,6-difluoro-3…
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