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13,161 results
  • Adaptive mechanisms following antidepressant drugs: Focus on serotonin 5-HT2A receptors. [Journal Article]
    Pharmacol Rep 2019; 71(6):994-1000Gawliński D, Smaga I, … Filip M
  • CONCLUSIONS: In conclusion, the present result indicate different sensitivity of brain 5-HT2A receptors to antidepressant drugs depending on schedule of drug administration and rat brain regions. The decrease of accumbal shell 5-HT2A receptor labeling by antidepressant drugs exhibiting different primary mechanism of action seems to be a common targeting mechanism associated with the outcome of depression treatment.
  • Effect of Imipramine on radiosensitivity of Prostate Cancer: An In Vitro Study. [Journal Article]
    Cancer Invest 2019; 37(9):489-500Barlaz Us S, Sogut F, … Comelekoglu U
  • Prostate cancer is the most common cancer and leading cause of cancer death for males. Imipramine (IMI), which is a tricyclic antidepressant, has also been shown to has antineoplastic effect. This study was performed to investigate the radiosensitizing effect of IMI on DU145 prostate cancer cell. Cells were divided into 4 groups. Cell index, apoptotic activity, cell cycle arrest, oxidative stress…
  • Protocols using detomidine and oxytocin induce ex copula ejaculation in stallions. [Journal Article]
    Theriogenology 2019; 140:93-98Cavalero TMS, Papa FO, … Freitas-Dell'aqua CP
  • Tricyclic antidepressives, such as imipramine, indirectly induce ejaculation by increasing the noradrenaline concentration, which triggers an α-adrenergic response, whereas α-adrenergic agonists, such as xylazine and detomidine, directly trigger ejaculation by activating the α-1 adrenergic receptors. Furthermore, serum oxytocin concentrations in stallions increase drastically before ejaculation, …
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