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(immune mediated inflammatory reaction)
20,484 results
  • Consideration of Maternal Anti-enterocyte IgA Transfer With Resulting Infantile Alloimmune Enteropathy. [Case Reports]
    ACG Case Rep J 2019; 6(6):e00093Luginbill JB, Rutledge JC, Giefer MJ
  • Autoimmune enteropathy is a rare cause of infantile diarrhea. Cases typically involve infants with a protracted course of diarrhea found to have underlying autoimmune disease or immune dysfunction, leading to chronic intestinal inflammation. We describe a case of immune-mediated enteropathy in an infant with no identifiable autoimmune disease. The patient was exclusively breastfed by his mother w…
  • The Role of MicroRNAs in Selected Forms of Glomerulonephritis. [Review]
    Int J Mol Sci 2019; 20(20)Nalewajska M, Gurazda K, … Dziedziejko V
  • Glomerulonephritis (GN) represents a collection of kidney diseases characterized by inflammation within the renal glomeruli and small blood vessels. The lesions that occur in other nephron structures mainly result from the harmful effects of proteinuria. In recent years, an emphasis has been placed on gaining a better insight into the pathogenesis and pathophysiology of GN in order to facilitate …
  • Liver X Receptors Regulate Cholesterol Metabolism and Immunity in Hepatic Nonparenchymal Cells. [Review]
    Int J Mol Sci 2019; 20(20)Endo-Umeda K, Makishima M
  • Excess dietary cholesterol intake and the dysregulation of cholesterol metabolism are associated with the pathogenesis and progression of nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and fibrosis. Hepatic accumulation of free cholesterol induces activation of nonparenchymal cells, including Kupffer cells, macrophages, and hepatic stellate cells, which leads to persistent inflam…
  • A unique conformational distortion mechanism drives Lipocalin 2 binding to bacterial siderophores. [Journal Article]
    ACS Chem Biol 2019Huang X, Slavkovic S, … Wilson DJ
  • Lcn2 is a host defense protein induced via the innate immune response to sequester iron-loaded bacterial siderophores. However, excess or prolonged elevation of Lcn2 levels can induce adverse cellular effects, including oxidative stress and inflammation. In this work, we use Hydrogen-Deuterium eXchange (HDX) and Isothermal Titration Calorimetry (ITC) to characterize the binding interaction betwee…
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