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487,929 results
  • StatPearls: Anatomy, Lymph Nodes [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Bujoreanu Iulia I Imperial College London Gupta Vikas V South Carolina Department of Mental Health BOOK
  • The lymphatic system is composed of lymphatic vessels and lymphoid organs such as the thymus, tonsils, lymph nodes, and the spleen. These assist in acquired and innate immunity, in filtering and draining the interstitial fluid and in recycling cells at the end of their life cycle. The fluid that leaks from end-stage capillaries returns to the vascular system via the superficial and deep lymphatic…
  • StatPearls: Aseptic Meningitis [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Kaur Hersimran H Northshore/Long Island Jewish (Northwell) Perera Thomas B. TB Hofstra Northwell BOOK
  • Aseptic meningitis is a term used to define inflammation of the brain meninges due to various etiologies with negative cerebrospinal fluid (CSF) bacterial cultures. It is one of the most common, usually benign, inflammatory disorders of the meninges. Viruses are a common etiology, however, there are many other infective and non-infective causes. Therefore, the terms aseptic meningitis and viral m…
  • Treatment of facial myiasis in an elderly patient with oral squamous cell carcinoma: Case report. [Case Reports]
    Int J Surg Case Rep. 2020 May 21; 71:260-265.Lazaro SA, Gordillo Yépez FD, … De Conto F
  • CONCLUSIONS: Myiasis can sometimes be associated with OSCC and it commonly occurs in individuals who live in unhealthy locations and present poor hygiene and low immunity. In addition to medication, the surgical removal of the larvae is important in the treatment of myiasis.Patient adherence to cancer treatment is essential to avoid the negative evolution of the tumor. The social component linked to the development of myiasis makes it an important public health topic, as it is related directly to the lack of primary care. Surgical and drug treatments are required to cure myiasis.
  • Microbiota-derived butyrate regulates intestinal inflammation: Focus on inflammatory bowel disease. [Review]
    Pharmacol Res. 2020 May 31 [Online ahead of print]Couto MR, Gonçalves P, … Martel F
  • Inflammatory bowel disease (IBD) refers to a group of heterogeneous disorders associated with chronic inflammation of the gut, having a high rate of incidence in the world. In the present review, we will discuss the link between the short-chain fatty acids, especially butyrate (BT), produced by bacterial fermentation of dietary fiber, and IBD development. Current knowledge supports an anti-inflam…
  • Cobbling Together the Myddosome. [Journal Article]
    Structure. 2020 Jun 02; 28(6):598-600.Snyder MLD, Snyder GA
  • An organism's ability to recognize and respond quickly and appropriately to pathogenic stimuli is a fundamental aspect of innate immunity. Harnessing the dynamic nature of fluorescent microscopy and the resolution of cryo-electron microscopy, Moncrieffe et al. (2020) characterize MyD88-only filaments and provide insight into the mechanisms underlying innate immune signaling.
  • Sustainability of antimicrobial stewardship programs in Australian rural hospitals: a qualitative study. [Journal Article]
    Aust Health Rev. 2020 Jun; 44(3):415-420.Bishop JL, Schulz TR, … Buising KL
  • Objective The aim of this study was to explore the features of sustainable antimicrobial stewardship (AMS) programs in Australian rural hospitals and develop recommendations on incorporating these features into rural hospitals' AMS programs. Methods Lead AMS clinicians with knowledge of at least one AMS program sustained for >2 years in a health service in rural Australia were recruited to the st…
  • SARS-CoV-2: A comprehensive review from pathogenicity of the virus to clinical consequences. [Review]
    J Med Virol. 2020 Jun 03 [Online ahead of print]Lotfi M, Rezaei N
  • Nowadays, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused novel coronavirus disease (COVID-19) pandemic, is the worldwide challenge. The virus is highly contagious, and clinical consequences were very divers. It is estimated that if no effective action is taken, COVID-19 could plague 90% of the world's population and kill over 40 million people. So, it is essential to u…
  • The Importance of Advancing SARS-CoV-2 Vaccines in Children. [Journal Article]
    Clin Infect Dis. 2020 Jun 03 [Online ahead of print]Kao CM, Orenstein WA, Anderson EJ
  • While the role of children in the chain of transmission of SARS-CoV-2 remains to be fully defined, they likely play an important role based on our knowledge of other respiratory viruses. Children are more likely to be asymptomatic or have milder symptoms and less likely to present for healthcare and be tested for SARS-CoV-2; thus, our current estimates are likely under-representative of the true …
  • Prenatal exposure to endocrine disrupting chemicals and asthma and allergic diseases. [Review]
    J Investig Allergol Clin Immunol. 2020 Jun 03 [Online ahead of print]Casas M, Gascon M
  • Endocrine-disrupting chemicals (EDCs), chemicals that can interfere with endogenous hormones and that are present in many consumer products, can affect the development and functions of the immune system. The prenatal period is critical because exposure to EDCs can induce irreversible changes in the immune system and increase the susceptibility of asthma and allergies later in life. Non-persistent…
  • Clinical and epidemiological characterization of severe Plasmodium vivax malaria in Gujarat, India. [Journal Article]
    Virulence. 2020 Jan 01; 11(1):730-738.Anvikar AR, van Eijk AM, … Wassmer SC
  • The mounting evidence supporting the capacity of Plasmodium vivax to cause severe disease has prompted the need for a better characterization of the resulting clinical complications. India is making progress with reducing malaria, but epidemics of severe vivax malaria in Gujarat, one of the main contributors to the vivax malaria burden in the country, have been reported recently and may be the re…
  • Immune Response to the Enteric Parasite Entamoeba histolytica. [Journal Article]
    Physiology (Bethesda). 2020 Jul 01; 35(4):244-260.Uribe-Querol E, Rosales C
  • Entamoeba histolytica is a protozoan parasite responsible for amoebiasis, a disease with a high prevalence in developing countries. Establishing an amoebic infection involves interplay between pathogenic factors for invasion and tissue damage, and immune responses for protecting the host. Here, we review the pathogenicity of E. histolytica and summarize the latest knowledge on immune response and…
  • Hepatic Choline Transport Is Inhibited During Fatty Acid-Induced Lipotoxicity and Obesity. [Journal Article]
    Hepatol Commun. 2020 Jun; 4(6):876-889.O'Dwyer C, Yaworski R, … Fullerton MD
  • Choline is an essential nutrient and a critical component of the membrane phospholipid phosphatidylcholine (PC), the neurotransmitter acetylcholine, while also contributing to the methylation pathway. In the liver specifically, PC is the major membrane constituent and can be synthesized by the cytidine diphosphate-choline or the phosphatidylethanolamine N-methyltransferase pathway. With the conti…
  • Decoding the Body Language of Immunity: Tackling the Immune System at the Organism Level. [Journal Article]
    Curr Opin Syst Biol. 2019 Dec; 18:19-26.Chevrier N
  • The immune system is a dynamic mesh of molecules, cells and tissues spanning the entire organism. Despite a wealth of knowledge about the components of the immune system, little is known about the general rules governing the organismal circuitry of immunity. Deciphering the immune system at the scale of the whole organism is crucial to understanding fundamental problems in immunobiology and physi…
  • Adjuvant activity of Mycobacteria-derived mycolic acids. [Journal Article]
    Heliyon. 2020 May; 6(5):e04064.Kubota M, Iizasa E, … Yoshida H
  • Successful vaccination, especially with safe vaccines such as component/subunit vaccines, requires proper activation of innate immunity and, for this purpose, adjuvant is used. For clinical use, alum is frequently used while, for experimental use, CFA, containing Mycobacterial components, was often used. In this report, we demonstrated that mycolic acids (MA), major and essential lipid components…
  • Plasmacytoid dendritic cell biology and its role in immune-mediated diseases. [Review]
    Clin Transl Immunology. 2020 May; 9(5):e1139.Ye Y, Gaugler B, … Malard F
  • Plasmacytoid dendritic cells (pDCs) are a unique subset of dendritic cells specialised in secreting high levels of type I interferons. pDCs play a crucial role in antiviral immunity and have been implicated in the initiation and development of many autoimmune and inflammatory diseases. This review summarises the latest advances in recent years in several aspects of pDC biology, with special focus…
  • Elevated blood eosinophils in acute COPD exacerbations: better short- and long-term prognosis. [Journal Article]
    Eur Clin Respir J. 2020; 7(1):1757274.Jabarkhil A, Moberg M, … Porsbjerg C
  • Background: Elevated eosinophils in COPD is recognized as a potential risk factor for exacerbations, but the prognostic role of elevated eosinophils during exacerbations of COPD is unclear. We investigated short-term and long-term outcomes in patients with exacerbations of eosinophilic phenotype, compared with patients with low blood eosinophils. Methods: A single-centre retrospective study of al…
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