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(immuno )
34,243 results
  • Waning immunity and re-emergence of measles and mumps in the vaccine era. [Review]
    Curr Opin Virol. 2020 Jul 04; 40:48-54.Yang L, Grenfell BT, Mina MJ
  • Vaccine-preventable diseases (VPD) including measles and mumps have been re-emerging in countries with sustained high vaccine coverage. For mumps, waning immunity has been recognized as a major contributor to recent outbreaks. Although unvaccinated individuals account for most cases in recent measles outbreaks, the role of immune waning remains unclear. Accumulating serological and epidemiologica…
  • Plasma Lipid Profile Reveals Plasmalogens as Potential Biomarkers for Colon Cancer Screening. [Journal Article]
    Metabolites. 2020 Jun 25; 10(6)Fernandes AMAP, Messias MCF, … Carvalho PO
  • In this era of precision medicine, there is an increasingly urgent need for highly sensitive tests for detecting tumors such as colon cancer (CC), a silent disease where the first symptoms may take 10-15 years to appear. Mass spectrometry-based lipidomics is an emerging tool for such clinical diagnosis. We used ultra-performance liquid chromatography coupled to electrospray ionization quadrupole …
  • Human Skin Equivalents Demonstrate Need for Neuro-Immuno-Cutaneous System. [Journal Article]
    Adv Biosyst. 2019 Jan; 3(1):e1800283.Vidal Yucha SE, Tamamoto KA, … Kaplan DL
  • A variety of human skin equivalents (HSEs) has been designed for clinical use or for exploratory skin research. In vitro HSE models have been used to target relationships between the skin and nervous or immune systems but have not yet considered the neuro-immuno-cutaneous (NIC) system. In this study, HSEs are described, with and without neural and immune components, to discern these types of effe…
  • Appropriateness to set a group health based guidance value for nivalenol and its modified forms. [Journal Article]
    EFSA J. 2017 Apr; 15(4):e04751.EFSA Panel on Contaminants in the Food Chain (CONTAM), Knutsen HK, … Alexander J
  • The EFSA Panel on Contaminants in the Food Chain (CONTAM) reviewed new studies on nivalenol since the previous opinion on nivalenol published in 2013, but as no new relevant data were identified the tolerable daily intake (TDI) for nivalenol (NIV) of 1.2 μg/kg body weight (bw) established on bases of immuno- and haematotoxicity in rats was retained. An acute reference dose (ARfD) of 14 μg/kg bw w…
  • Correlative light and electron microscopy of wall formation in Eimeria nieschulzi. [Journal Article]
    Parasitol Res. 2020 Jul 06 [Online ahead of print]Wiedmer S, Kurth T, … Kurth M
  • Coccidian parasites possess complex life cycles involving asexual proliferation followed by sexual development leading to the production of oocysts. Coccidian oocysts are persistent stages which are secreted by the feces and transmitted from host to host guaranteeing life cycle progression and disease transmission. The robust bilayered oocyst wall is formed from the contents of two organelles, th…
  • Histone Deacetylase Inhibitors to Overcome Resistance to Targeted and Immuno Therapy in Metastatic Melanoma. [Review]
    Front Cell Dev Biol. 2020; 8:486.Yeon M, Kim Y, … Jeoung D
  • Therapies that target oncogenes and immune checkpoint molecules constitute a major group of treatments for metastatic melanoma. A mutation in BRAF (BRAF V600E) affects various signaling pathways, including mitogen activated protein kinase (MAPK) and PI3K/AKT/mammalian target of rapamycin (mTOR) in melanoma. Target-specific agents, such as MAPK inhibitors improve progression-free survival. However…
  • Emerging Roles of Mast Cells in the Regulation of Lymphatic Immuno-Physiology. [Review]
    Front Immunol. 2020; 11:1234.Pal S, Nath S, … Gashev AA
  • Mast cells (MCs) are abundant in almost all vascularized tissues. Furthermore, their anatomical proximity to lymphatic vessels and their ability to synthesize, store and release a large array of inflammatory and vasoactive mediators emphasize their significance in the regulation of the lymphatic vascular functions. As a major secretory cell of the innate immune system, MCs maintain their steady-s…
  • Surmounting the obstacles that impede effective CAR T cell trafficking to solid tumors. [Review]
    J Leukoc Biol. 2020 Jul 03 [Online ahead of print]Donnadieu E, Dupré L, … Cotta-de-Almeida V
  • Innovative immunotherapies based on immune checkpoint targeting antibodies and engineered T cells are transforming the way we approach cancer treatment. However, although these T cell centered strategies result in marked and durable responses in patients across many different tumor types, they provide therapeutic efficacy only in a proportion of patients. A major challenge of immuno-oncology is t…
  • The blood cells in NSCLC and the changes after RFA. [Journal Article]
    Int J Hyperthermia. 2020; 37(1):753-762.Li Y, Wang D, Li X
  • Lung cancer has attracted a lot of attention because of its high morbidity and mortality. The emergence of RFA provides a new treatment for unresectable NSCLC patients. In addition to killing in situ lung tumors, RFA also provides new immuno-activated antigens, for the treatment of lung cancer. It changes the tumor microenvironment and activates the entire immune system of patients. The periphera…
  • Morphometric image analysis of vascular endothelial growth factor receptor-3 in preeclamptic, HIV infected women. [Journal Article]
    Eur J Obstet Gynecol Reprod Biol. 2020 Jun 09 [Online ahead of print]Pillay S, Naicker T
  • CONCLUSIONS: The results presented provide compelling evidence that HIV infection does not significantly alter angiogenesis in placental villi. PE however, has caused angiogenic dysregulation and trophoblast pathology was observed. We report a severe downregulation of VEGFR-3 in placental villi from EOPE woman, regardless of HIV status. Hence we suggest a future investigation into EOPE's aetiology and its downstream effects on pregnancy.
  • HIV-1 subtype C transmitted founders modulate dendritic cell inflammatory responses. [Journal Article]
    Retrovirology. 2020 Jul 02; 17(1):17.Lumngwena EN, Metenou S, … Woodman Z
  • CONCLUSIONS: Overall, this could suggest that the genetics of the virus itself influences inflammatory responses during HIV infection. In the absence of pre-existing infections, induction of greater inflammatory response by TFs might favour virus survival within the healthy FGT by driving an influx of target cells to sites of infection while suppressing immune responses via IL-10.
  • Stimulation with FITC-labeled antigens confers B cells with regulatory properties. [Journal Article]
    Cell Immunol. 2020 Jun 12; 355:104151.Planchais C, Rayes J, … Lacroix-Desmazes S
  • B cells with regulatory properties (Bregs) were identified in human and in mice among different B-cell subsets. Their regulatory properties rely mainly on the production of anti-inflammatory cytokines, in particular IL10, IL-35 and TGFβ, and were extensively studied in mouse models of autoimmune and inflammatory diseases. However, the exact nature of the stimulatory signals conferring regulatory …
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