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1,542 results
  • Archangelolide: A sesquiterpene lactone with immunobiological potential from Laserpitium archangelica. [Journal Article]
    Beilstein J Org Chem 2019; 15:1933-1944Rimpelová S, Jurášek M, … Ruml T
  • Sesquiterpene lactones are secondary plant metabolites with sundry biological effects. In plants, they are synthesized, among others, for pesticidal and antimicrobial effects. Two such compounds, archangelolide and trilobolide of the guaianolide type, are structurally similar to the well-known and clinically tested lactone thapsigargin. While trilobolide has already been studied by us and others,…
  • Role of IL-33 in transplant biology. [Journal Article]
    Eur Cytokine Netw 2019; 30(2):39-42Jin Y, Kong D, … Gong W
  • Since the pro-inflammatory cytokine IL-33 and its receptor (ST2) are closely involved in regulating both innate and adaptive immune responses, it is conceivable that they may play an important role in organ transplantation. IL-33 is broadly expressed by multiple cell types such as fibroblasts, epithelial cells, and endothelial cells. As a strong inducer of type 2 helper T (Th2) cellular immune re…
  • Double anti-B cell and anti-BAFF targeting for the treatment of primary Sjögren's syndrome. [Review]
    Clin Exp Rheumatol 2019 May-Jun; 37 Suppl 118(3):199-208Gandolfo S, De Vita S
  • Primary Sjögren's syndrome (pSS) is an autoimmune connective tissue disease characterised by an enhanced lymphoproliferative status, with a greater risk of hesitating in malignant lymphoma. The pathological hallmark of pSS is the mucosa-associated lymphoid tissue (MALT) arising in chronically inflamed tissues, mainly in salivary glands (SG), where inflammation, autoimmunity and lymphoproliferatio…
  • Drugging cancer metabolism: Expectations vs. reality. [Journal Article]
    Int Rev Cell Mol Biol 2019; 347:1-26Montrose DC, Galluzzi L
  • As compared to their normal counterparts, neoplastic cells exhibit a variety of metabolic changes that reflect not only genetic and epigenetic defects underlying malignant transformation, but also the nutritional and immunobiological conditions of the tumor microenvironment. Such alterations, including the so-called Warburg effect (an increase in glucose uptake largely feeding anabolic and antiox…
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