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159,836 results
  • Primary immunization using low antigen dosages and immunological tolerance in rainbow trout. [Journal Article]
    Fish Shellfish Immunol. 2020 Jun 30 [Online ahead of print]Marana MH, Chettri JK, … Buchmann K
  • Enteric redmouth disease (ERM), caused by the Gram negative enterobacterium Yersinia ruckeri, affects farming of salmonids, but vaccination against ERM confers a certain degree of protection dependent on the administration route. Recent studies on oral vaccination of rainbow trout suggest that immunological tolerance may be induced by primary immunization using a low antigen dosage. We have exami…
  • Trends in pediatric skin cancer. [Journal Article]
    Curr Opin Pediatr. 2020 Jun 30 [Online ahead of print]Moustafa D, Neale H, Hawryluk EB
  • CONCLUSIONS: Melanoma in pediatric patients often presents differently from conventional adult melanoma, including Spitz melanoma and melanoma associated with congenital melanocytic nevi. Pediatric patients with nonmelanoma skin cancers should be evaluated for predisposing risk factors. More research on therapeutic options for pediatric skin cancer is vital to understanding the tolerance and response of our pediatric patients to therapies that are more frequently utilized in adult disease.
  • Fecal microbial transplant for inflammatory bowel disease. [Journal Article]
    Curr Opin Clin Nutr Metab Care. 2020 Jun 28 [Online ahead of print]Claytor JD, El-Nachef N
  • CONCLUSIONS: The allure of minimizing the risks and cost of long-term immunosuppression via modulation of patient microbiota remains enticing, and the most recent randomized controlled data in ulcerative colitis reveals acceptable clinical remission rates. However, prior to wide adoption of FMT within the inflammatory bowel disease treatment armamentarium, large clinical trials identifying biomarkers of treatment success, ensuring safety across all indications, and cultivating optimized donor and host selection are needed.
  • The Gut-Eye Axis: Lessons Learned from Murine Models. [Review]
    Ophthalmol Ther. 2020 Jul 02 [Online ahead of print]Floyd JL, Grant MB
  • A healthy gut microbiota is essential in maintaining the human body in a homeostatic state by its functions in digestion and immune tolerance. Under states of aberrant microbial composition or function (dysbiosis), the gut microbiota induces systemic inflammation that can lead to the onset of many diseases. In this review, we describe some evidence, largely from rodent studies, that supports the …
  • Engineering immunomodulatory biomaterials for type 1 diabetes. [Journal Article]
    Nat Rev Mater. 2019 Jun; 4(6):429-450.Stabler CL, Li Y, … Keselowsky BG
  • A cure for type 1 diabetes (T1D) would help millions of people worldwide, but remains elusive thus far. Tolerogenic vaccines and beta cell replacement therapy are complementary therapies that seek to address aberrant T1D autoimmune attack and subsequent beta cell loss. However, both approaches require some form of systematic immunosuppression, imparting risks to the patient. Biomaterials-based to…
  • Tryptophan Metabolism, Regulatory T Cells, and Inflammatory Bowel Disease: A Mini Review. [Review]
    Mediators Inflamm. 2020; 2020:9706140.Ding X, Bin P, … Zhu G
  • Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract resulting from the homeostasis imbalance of intestinal microenvironment, immune dysfunction, environmental and genetic factors, and so on. This disease is associated with multiple immune cells including regulatory T cells (Tregs). Tregs are a subset of T cells regulating the function of various immun…
  • Sustained Immunoparalysis in Endotoxin-Tolerized Monocytic Cells. [Journal Article]
    Mediators Inflamm. 2020; 2020:8294342.Weisheit CK, Klüners A, … Ehrentraut H
  • Sepsis is associated with a strong inflammatory reaction triggering a complex and prolonged immune response. Septic patients have been shown to develop sustained immunosuppression due to a reduced responsiveness of leukocytes to pathogens. Changes in cellular metabolism of leukocytes have been linked to this phenomenon and contribute to the ongoing immunological derangement. However, the underlyi…
  • Molecular mechanisms of human herpes viruses inferring with host immune surveillance. [Review]
    J Immunother Cancer. 2020 Jul; 8(2)Jasinski-Bergner S, Mandelboim O, Seliger B
  • Several human herpes viruses (HHVs) exert oncogenic potential leading to malignant transformation of infected cells and/or tissues. The molecular processes induced by viral-encoded molecules including microRNAs, peptides, and proteins contributing to immune evasion of the infected host cells are equal to the molecular processes of immune evasion mediated by tumor cells independently of viral infe…
  • HIV-1 subtype C transmitted founders modulate dendritic cell inflammatory responses. [Journal Article]
    Retrovirology. 2020 Jul 02; 17(1):17.Lumngwena EN, Metenou S, … Woodman Z
  • CONCLUSIONS: Overall, this could suggest that the genetics of the virus itself influences inflammatory responses during HIV infection. In the absence of pre-existing infections, induction of greater inflammatory response by TFs might favour virus survival within the healthy FGT by driving an influx of target cells to sites of infection while suppressing immune responses via IL-10.
  • Discovery and Function of B Cell IgD Low (BDL) B Cells in Immune Tolerance. [Review]
    J Mol Biol. 2020 Jun 29 [Online ahead of print]Khalil MI, Gurski CJ, … Dittel BN
  • It is now appreciated that in addition to their role in humoral immunity B cells also exert regulatory mechanisms that lead to attenuation of inflammatory responses. The concept of B cell regulation became well-recognized when mice deficient in B cells due to genetic disruption were shown to be refractory to recovery from the signs of experimental autoimmune encephalomyelitis (EAE), the mouse mod…
  • Fungal recognition by mammalian fibrinogen-related proteins. [Journal Article]
    Scand J Immunol. 2020 Jul 02 [Online ahead of print]Pilecki B, Moeller JB
  • Fungi are ubiquitous eukaryotic microorganisms present in virtually all environmental habitats. Although rarely pathogenic to the healthy population, many fungal species are capable of causing human disease in immunocompromised individuals. Thus, fungal infections remain a significant cause of morbidity and mortality, with rising prevalence accompanying the worldwide increase in immunosuppression…
  • The multifaceted functional role of DNA methylation in immune-mediated rheumatic diseases. [Review]
    Clin Rheumatol. 2020 Jul 02 [Online ahead of print]Vecellio M, Wu H, … Selmi C
  • Genomic predisposition cannot explain the onset of complex diseases, as well illustrated by the largely incomplete concordance among monozygotic twins. Epigenetic mechanisms, including DNA methylation, chromatin remodelling and non-coding RNA, are considered to be the link between environmental stimuli and disease onset on a permissive genetic background in autoimmune and chronic inflammatory dis…
  • Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies. [Review]
    Front Immunol. 2020; 11:1185.Zhai L, Bell A, … Wainwright DA
  • Indoleamine 2, 3-dioxygenase 1 (IDO; IDO1; INDO) is a rate-limiting enzyme that metabolizes the essential amino acid, tryptophan, into downstream kynurenines. Canonically, the metabolic depletion of tryptophan and/or the accumulation of kynurenine is the mechanism that defines how immunosuppressive IDO inhibits immune cell effector functions and/or facilitates T cell death. Non-canonically, IDO a…
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