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154,152 results
  • Immune regulatory molecules as modifiers of semen and fertility: A review. [Review]
    Mol Reprod Dev 2019Archana SS, Selvaraju S, … Krawetz SA
  • Declining fertility rates in both human and animals is a cause for concern. While many of the infertility cases are due to known causes, idiopathic infertility is reported in 30% of the infertile couples. In such cases, 18% of the infertile males carry antisperm antibodies (ASAs). Such data are lacking in livestock, wherein 20-30% of the animals are being culled due to low fertility. In males, th…
  • Helios: Still Behind the Clouds. [Review]
    Immunology 2019Thornton AM, Shevach EM
  • T Regulatory (Treg) cells are a subset of CD4+ T cells that are critical for the maintenance of self-tolerance. The forkhead box transcription factor Foxp3 is a master regulator for the Treg phenotype and function and its expression is essential in Treg cells, as the loss of Foxp3 results in lethal autoimmunity. Two major subsets of Treg cells have been described in vivo; thymic-derived Treg cell…
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