- Image-guided Preoperative Localization of Pulmonary Nodules for Video-assisted and Robotically Assisted Surgery. [Journal Article]Radiographics 2019; :180183R
- Video-assisted thoracic surgery (VATS) and robotically assisted surgery are used increasingly for minimally invasive diagnostic and therapeutic resection of pulmonary nodules. Unsuccessful localization of small, impalpable, or deep pulmonary nodules can necessitate conversion from VATS to open thoracotomy. Preoperative localization techniques performed by radiologists have improved the success ra…
Video-assisted thoracic surgery (VATS) and robotically assisted surgery are used increasingly for minimally invasive diagnostic and therapeutic resection of pulmonary nodules. Unsuccessful localization of small, impalpable, or deep pulmonary nodules can necessitate conversion from VATS to open thoracotomy. Preoperative localization techniques performed by radiologists have improved the success rates of VATS resection for small and subsolid nodules. Any center at which VATS diagnostic resection of indeterminate pulmonary nodules is performed should be supported by radiologists who offer preoperative nodule localization. Many techniques have been described, including image-guided injection of radioisotopes and radiopaque liquids and placement of metallic wires, coils, and fiducial markers. These markers enable the surgeon to visualize the position of an impalpable nodule intraoperatively. This article provides details on how to perform each percutaneous localization technique, and a group of national experts with established nodule localization programs describe their preferred approaches. Special reference is made to equipment required, optimization of marker placement, prevention of technique-specific complications, and postprocedural treatment. This comprehensive unbiased review provides valuable information for those who are considering implementation or optimization of a nodule localization program according to workflow patterns, surgeon preference, and institutional resources in a particular center. ©RSNA, 2019.
- Resection margins and local recurrences of impalpable breast cancer: Comparison between radioguided occult lesion localization (ROLL) and radioactive seed localization (RSL). [Journal Article]Breast 2019; 47:93-101B
- CONCLUSIONS: Reoperation rates and LRFS were comparable for ROLL and RSL in patients with impalpable breast cancer treated with BCS.
- A comparison of stereotactic and tomosynthesis-guided localisation of impalpable breast lesions. [Journal Article]J Med Radiat Sci 2019JM
- CONCLUSIONS: The degree of accuracy of pre-operative localisation of impalpable breast lesions is significantly higher with the use of prone stereotactic rather than upright tomosynthesis guidance. This was most evident with the placement of I-125 seeds, and in cases where the target lesion was located below the level of the nipple.
- Uniportal VATS Coil-Assisted Resections for GGOs. [Journal Article]J Oncol 2019; 2019:5383086JO
- CONCLUSIONS: Preoperative CT-guided coil localization seems to be a feasible, safe, and accurate procedure. It makes uniportal VATS an easy approach even for resecting small, deep, and impalpable nodules.
- Experiences of localization and removal of non-palpable subdermal contraceptive implants with ultrasound. [Journal Article]Obstet Gynecol Sci 2019; 62(3):166-172OG
- CONCLUSIONS: High frequency ultrasonography is a highly accurate tool for localization and measurement of the skin-to-rod depth. It is also useful for removing non-palpable implants. If the depth of the implant is >12.0 mm, removal of the implant in the operating room under general anesthesia is recommended.
- Clinical value of 18F-FDG-PET/CT in staging cutaneous squamous cell carcinoma. [Journal Article]Nucl Med Commun 2019; 40(7):744-751NM
- CONCLUSIONS: F-FDG-PET/CT has high sensitivity in the detection of cSCC lesions, including small cutaneous and nodal disease, and has a potential role in initial staging and management.
- Safe resection margin in video-assisted left anterior and lingular segmentectomy for an impalpable lung nodule. [Journal Article]Int J Surg Case Rep 2019; 59:7-10IJ
- CONCLUSIONS: Because of the location, the tumor is traditionally resected by left upper lobectomy. However, we planned a minimally invasive intervention and performed anterior and lingular segmentectomy by VATS using a CT-guided nodule marking prior to the surgery.This technique resulted in complete tumor resection with minimal adverse effects.
- Targeted biopsy of the prostate: does this result in improvement in detection of high-grade cancer or the occurrence of the Will Rogers phenomenon? [Journal Article]BJU Int 2019BI
- CONCLUSIONS: The use of targeted biopsy in men with impalpable cancer, ultimately upgraded one in five patients from favourable-intermediate- to unfavourable-intermediate-risk disease or worse. This has significant clinical implications for men considering active surveillance or radical treatment. Our risk calculators must now be validated using these data from targeted biopsy as the technique becomes widely adopted.
- Proportional hazards regression of survival-sacrifice data with cause-of-death information in animal carcinogenicity studies. [Journal Article]Stat Med 2019; 38(19):3628-3641SM
- Rodent survival-sacrifice experiments are routinely conducted to assess the tumor-inducing potential of a certain exposure or drug. Because most tumors under study are impalpable, animals are examined at death for evidence of tumor formation. In some studies, the cause of death is ascertained by a pathologist to account for possible correlation between tumor development and death. Existing method…
Rodent survival-sacrifice experiments are routinely conducted to assess the tumor-inducing potential of a certain exposure or drug. Because most tumors under study are impalpable, animals are examined at death for evidence of tumor formation. In some studies, the cause of death is ascertained by a pathologist to account for possible correlation between tumor development and death. Existing methods for survival-sacrifice data with cause-of-death information have been restricted to multi-group testing or one-sample estimation of tumor onset distribution and thus do not provide a natural way to quantify treatment effect or dose-response relationship. In this paper, we propose semiparametric regression methods under the popular proportional hazards model for both tumor onset and tumor-caused death. For inference, we develop a maximum pseudo-likelihood estimation procedure using a modified iterative convex minorant algorithm, which is guaranteed to converge to the unique maximizer of the objective function. Simulation studies under different tumor rates show that the new methods provide valid inference on the covariate-outcome relationship and outperform alternative approaches. A real study investigating the effects of benzidine dihydrochloride on liver tumor in mice is analyzed as an illustration.
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- Detection of indocyanine green fluorescence to determine tumor location during laparoscopic gastrectomy for gastric cancer: Results of a prospective study. [Journal Article]Asian J Endosc Surg 2019AJ
- CONCLUSIONS: The preoperative submucosal ICG marking was safely performed and successfully detected without excessive blurring during laparoscopic gastrectomy.