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138 results
  • Shedding light on excessive crying in babies. [Journal Article]
    Pediatr Res. 2020 Jul 06 [Online ahead of print]Adam-Darque A, Freitas L, … Ha-Vinh Leuchter R
  • CONCLUSIONS: Our results offer novel insights into IC pathophysiology by demonstrating that, shortly after birth, the central nervous system of babies developing IC has already greater reactivity to sensory stimuli than that of their noncolicky peers.Shortly after birth, the central nervous system of colicky infants has a greater sensitivity to olfactory stimuli than that of their noncolicky peers. This early sensitivity explains as much as 48% of their subsequent crying behavior at 6 weeks of life.Brain activation patterns to olfactory stimuli in colicky infants include not only primary olfactory areas but also brain regions involved in pain processing, emotional valence attribution, and self-regulation.This study links earlier findings in fields as diverse as gastroenterology and behavioral psychology and has the potential of helping healthcare professionals to define strategies to advise families.
  • A Particular Form of "Urolithiasis" in a Toddler. [Journal Article]
    Pediatrics. 2020 Jun; 145(6)Marzuillo P, Capalbo D, … Miraglia Del Giudice E
  • Milk of calcium is a viscous colloidal suspension of calcium salts that forms in dilated cysts or cavities. We present, for the first time in literature, a toddler with isolated milk of calcium and treated with a conservative approach. A boy with a history of one urinary tract infection and recurrent fever without vesicoureteral reflux showed at the age of 14 months a left obstructive staghorn st…
  • Subacute Neuropsychiatric Syndrome in Girls With SHANK3 Mutations Responds to Immunomodulation. [Case Reports]
    Pediatrics. 2020 02; 145(2)Bey AL, Gorman MP, … Van Haren K
  • Phenotypic and biological characterization of rare monogenic disorders represents 1 of the most important avenues toward understanding the mechanisms of human disease. Among patients with SH3 and multiple ankyrin repeat domains 3 (SHANK3) mutations, a subset will manifest neurologic regression, psychosis, and mood disorders. However, which patients will be affected, when, and why are important un…
  • Human parechovirus type 5 neurological infection in a neonate with a favourable outcome: A case report. [Case Reports]
    Int J Infect Dis. 2019 Dec; 89:175-178.Piralla A, Perniciaro S, … Baldanti F
  • The majority of parechovirus A type 5 (PeV-A5) infections have been reported in patients with gastrointestinal syndromes. In contrast, a sepsis-like illness associated with PeV-A5 infection has been reported only anecdotally. Herein, we report the first case in Italy of a PeV-A5 neurological infection presenting in a neonate with a sepsis-like syndrome. The patient, a healthy male infant born at …
  • GeneReviews®: MECP2 Disorders [BOOK]
    . University of Washington, Seattle: Seattle (WA)Adam MP, Ardinger HH, … Amemiya AKaur S, Christodoulou JBOOK
  • The spectrum of MECP2-related phenotypes in females ranges from classic Rett syndrome to variant Rett syndrome with a broader clinical phenotype (either milder or more severe than classic Rett syndrome) to mild learning disabilities; the spectrum in males ranges from severe neonatal encephalopathy to pyramidal signs, parkinsonism, and macroorchidism (PPM-X) syndrome to severe syndromic/nonsyndrom…
  • Preventing and Treating Colic. [Review]
    Adv Exp Med Biol. 2019; 1125:49-56.Indrio F, Dargenio VN, … Francavilla R
  • Colic is a common and distressing functional gastrointestinal disorder during infancy. It is a behavioral phenomenon in infants aged 1-4 months involving prolonged inconsolable crying and agitated status with multifactorial etiology. Colic can be considered as a benign, self-limited process because the baby normally grows and feeds even with transient irritable mood. Nevertheless, infantile colic…
  • Non-traumatic Infantile Slipped Capital Femoral Epiphysis following an Epileptic Seizure - A Case Report. [Case Reports]
    J Orthop Case Rep. 2019; 9(5):35-38.Kyriakos P, Dimitrios S, … Fares S
  • CONCLUSIONS: This unique case of a 10-month-old infant who developed SCFE following an epileptic seizure shows that this rare fracture may occur even in very young children. Although it is not currently indicated for the treatment of the vast majority of patients with SCFE, closed reduction and immobilization in a hip spicacast may be considered as an alternative treatment option in carefully selected patients.
  • Children with Cryptorchidism Complicated by Testicular Torsion: A Case Series. [Case Reports]
    Urol Int. 2019; 102(1):113-117.Deng T, Zhang X, … Jiang X
  • CONCLUSIONS: Cryptorchidism is an emergency in pediatric urology and often leads to a low testicular salvage rate, especially in infants, due to lack of knowledge, delayed diagnosis, and late treatment. Neonatal genital examination is important for the early diagnosis and management of cryptorchidism.
  • Benign nocturnal alternating hemiplegia of childhood: A clinical and nomenclatural reappraisal. [Case Reports]
    Eur J Paediatr Neurol. 2018 Nov; 22(6):1110-1117.Maas RPPWM, Kamsteeg EJ, … Willemsen MAAP
  • CONCLUSIONS: We underscore the phenotypic homogeneity including the self-limiting course of BNAHC episodes and suggest the condition be renamed 'benign childhood hemiplegia during sleep' (BCHS). We propose a role for the PRRT2 gene and the resulting neuronal hyperexcitability as one of its possible underpinning mechanisms and discuss the clinical similarities of BCHS with the recognized PRRT2-related disorders.
  • StatPearls: Colic [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Banks J B. JB Grand Strand Medical Center Rouster Audra S. AS West Viginia University Chee J J Grand Strand Medical Center BOOK
  • Infant colic is challenging for new parents and is a reason for 10% to 20% of pediatrician visits during the early weeks of an infant's life. Colic is estimated at affecting 5% to 40% of infants worldwide. The condition typically presents in the second or third week of life, peaks around 6 weeks, and resolves by the age of 12 weeks in 60% of infants and by 16 weeks of age in 90%. Inconsolable cry…
  • A laboratory model for evaluating relapse of undesirable caregiver behavior. [Journal Article]
    J Exp Anal Behav. 2018 09; 110(2):252-266.Mitteer DR, Greer BD, … Wacker DP
  • The success of behavioral treatments like functional communication training depends on their continued implementation outside of the clinical context, where failures in caregiver treatment adherence can lead to the relapse of destructive behavior. In the present study, we developed a laboratory model for evaluating the relapse of undesirable caregiver behavior that simulates two common sources of…
  • Why do babies cry? [Review]
    Arch Dis Child. 2018 11; 103(11):1077-1079.Scott-Jupp R
  • Persistent, inconsolable crying in young infants is common, distressing but usually benign. This selective review examines perceptions and perceived origins of this phenomenon in babies where serious pathology has been excluded. Adult brains have evolved to become hypersensitive to infant cries. Babies respond to parental stress by crying more, thus setting up a vicious cycle. Most treatments app…
  • Prevention of Emergence Agitation with Ketamine in Rhinoplasty. [Randomized Controlled Trial]
    Aesthetic Plast Surg. 2018 Jun; 42(3):847-853.Demir CY, Yuzkat N
  • CONCLUSIONS: Emergence agitation after rhinoplasty is a common complication, likely disturbing operative outcomes in adults. Ketamine at sub-anesthetic doses is highly effective in preventing EA. Further, larger-scale prospective studies are warranted to determine preventive measures for EA development in rhinoplasty.
  • Chiari type I malformation of infants and toddlers. [Journal Article]
    Childs Nerv Syst. 2018 06; 34(6):1169-1176.Grahovac G, Pundy T, Tomita T
  • CONCLUSIONS: Young patients lacking effective verbal communication often present their Chiari I malformation differently from olderage groups. Behavioral changes indicative of headaches/irritability and oropharyngeal/respiratory symptoms are the primary presenting symptoms. The recurrence rate tends to be higher among the patients after Type 1 procedure (particularly those younger than 18 months) than after Type 2 procedure. We observed that duraplasty at primary or at redo PFD provides for better decompression and long-term outcome. However, one should keep it in mind that there is risk of CSF-related complications following duraplasty, particularly higher tendency after redo PFD.
  • Vaccines to Children: Protective Effect and Adverse Events: A Systematic Review [BOOK]
    . Swedish Council on Health Technology Assessment (SBU): Stockholm Swedish Council on Health Technology Assessment BOOK
  • Few medical interventions have had as great an impact on global health as immunisation of children. Extensive immunisation programmes have eradicated smallpox completely and eliminated polio in all but a handful of countries. Thus, the benefits of immunisation are indisputable. But it is important to critically examine an intervention that is recommended for all infants. Routine immunisation must…
  • Parenting the Crying Infant. [Journal Article]
    Curr Opin Psychol. 2017 Jun; 15:149-154.Zeifman DM, St James-Roberts I
  • Crying conveys evidence about an infant's state and neurological health which, when carefully assessed, can provide diagnostic information for parents and clinicians. When crying is inconsolable or judged to be excessive, it can stress parents, disrupt parenting and, in rare cases, place an infant at risk for abuse. Research has revealed physiological and neural responses to crying that may predi…
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