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2,727 results
  • Antiviral Drugs and Acute Kidney Injury (AKI). [Journal Article]
    Infect Disord Drug Targets 2019Leowattana W
  • The introductions of more efficient antiviral drugs are common cause drug-induced acute kidney injury (AKI). The true prevalence of antiviral drugs induced nephrotoxicity is hardly determined. It causes AKI by many mechanisms including acute tubular necrosis (ATN), allergic interstitial nephritis (AIN), and crystal nephropathy. ATN has been described with a few kinds of antiviral drugs such as ci…
  • Desolvation behavior of indinavir sulfate ethanol and follow-up by terahertz spectroscopy. [Journal Article]
    Int J Pharm 2019; 567:118446Ito M, Tokuda R, … Noguchi S
  • Active pharmaceutical ingredients are composed of single-component or multicomponent crystals. Multicomponent crystals include salts, co-crystals, and solvates. Indinavir sulfate is the ethanol solvate form of indinavir that is known to deliquesce through moisture absorption. However, the detailed behavior of solvent molecules in the crystal has not been investigated. In this study, we studied th…
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