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44,360 results
  • A Method for the Evaluation of Site-Specific Nephrotoxic Injury in the Intact Rat Kidney. [Journal Article]
    Toxics 2020; 8(1)Edwards J, Kowal M, … Prozialeck W
  • In a previously published report we detailed an in situ method to quantify cell death in the renal cortex by perfusing the cell membrane impermeable fluorochrome, ethidium homodimer in situ. The objective of the present study was to use this in situ viability assay to examine cell death following the administration of nephrotoxic drugs known to produce cell death and/or injury in specific segment…
  • Block Copolymer Nanosystems Encapsulating Magnetic Nanoparticles and Drug. [Journal Article]
    J Nanosci Nanotechnol 2020; 20(7):3981-3988Vlassi E, Papagiannopoulos A, … Pispas S
  • The goal of this study was to investigate the solution behavior of nanosystems composed of self-assembling amphiphilic diblock copolymers, poly(ethylene oxide-b-phenyl oxazoline) and poly(isoprene-b-ethylene oxide) (PEO-b-PPhOx and PI-b-PEO), with encapsulated iron oxide nanoparticles (γ-Fe₂O₃). The hybrid nanosystems were tested in aqueous solution, under physiological conditions and in mixtures…
  • Endoplasmic Reticulum Stress Contributes to Indomethacin-Induced Glioma Apoptosis. [Journal Article]
    Int J Mol Sci 2020; 21(2)Chang CY, Li JR, … Chen CJ
  • The dormancy of cellular apoptotic machinery has been highlighted as a crucial factor in therapeutic resistance, recurrence, and poor prognosis in patients with malignancy, such as malignant glioma. Increasing evidence indicates that nonsteroidal anti-inflammatory drugs (NSAIDs) confer chemopreventive effects, and indomethacin has been shown to have a novel chemotherapeutic application targeting …
  • Gonadal function protects against organ culture-induced vascular damage. Involvement of prostanoids. [Journal Article]
    Prostaglandins Other Lipid Mediat 2020; :106406Villalpando DM, Rivas JG, … Ferrer M
  • Androgen deprivation induces vascular dysfunction in which altered release and action of prostanoids has been extensively studied. On the other hand, the vascular organ-culture system has been reported as a valid model for phenotypic changes that occur in several cardiovascular pathologies. Since there are no studies analyzing the impact of androgenic loss on vascular vulnerability during induced…
  • Selected pharmacotherapy agents as antiproliferative and anti-inflammatory compounds. [Journal Article]
    Drug Dev Res 2020AlKhalil M, Al-Hiari Y, … Telfah A
  • The repurposing of safe therapeutic drugs has emerged as an alternative approach to rapidly identify effective, safe, and conveniently available therapeutics to treat/prevent cancer. Therefore, it was hypothesized that acidic chelator drugs could have a genuine potential as antiproliferative agents. Based on their pKa, the selected 15 acidic drugs of eight classes-namely sulfonylureas, proton pum…
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