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1,294 results
  • Uremic Toxins and Atrial Fibrillation: Mechanisms and Therapeutic Implications. [Review]
    Toxins (Basel) 2019; 11(10)Yamagami F, Tajiri K, … Ieda M
  • Atrial fibrillation (AF) is the most prevalent arrhythmia in the general population. There is a close association between chronic kidney disease (CKD) and AF. In recent years, attention has been focused on the relationship between AF and uremic toxins, including indoxyl sulfate (IS). Several animal studies have shown that IS promotes the development and progression of AF. IS has been shown to cau…
  • The gut microbiota and its relationship with chronic kidney disease. [Review]
    Int Urol Nephrol 2019Plata C, Cruz C, … Ramírez V
  • Chronic kidney disease (CKD) is a worldwide health problem, because it is one of the most common complications of metabolic diseases including obesity and type 2 diabetes. Patients with CKD also develop other comorbidities, such as hypertension, hyperlipidemias, liver and cardiovascular diseases, gastrointestinal problems, and cognitive deterioration, which worsens their health. Therapy includes …
  • Domino Grignard Addition and Oxidation for the One-Pot Synthesis of C2-Quaternary 2-Hydroxyindoxyls. [Journal Article]
    Org Lett 2019; 21(19):8044-8048Mandal T, Chakraborti G, … Dash J
  • We herein delineate an unexplored reactivity of 3-hydroxyoxindoles toward Grignard addition enabling a rapid access to a broad range of unnatural C2-quaternary 2-hydroxyindoxyls in high yields. The reaction proceeds via a mechanistically intriguing one-pot 1,2-hydride shift followed by autoxidation pathway. The utility of this method is demonstrated by the synthesis of a new class of bis-indoxyl …
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