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124 results
  • Tcf4 is required for correct brain development during embryogenesis. [Journal Article]
    Mol Cell Neurosci. 2020 May 28; 106:103502.Mesman S, Bakker R, Smidt MP
  • Tcf4 has been linked to autism, schizophrenia, and Pitt-Hopkins Syndrome (PTHS) in humans, suggesting a role for Tcf4 in brain development and importantly cortical development. However, the mechanisms behind its role in disease and brain development are still elusive. We provide evidence that Tcf4 has a critical function in the differentiation of cortical regions, corpus callosum and anterior com…
  • Corpus Callosum: Molecular Pathways in Mice and Human Dysgeneses. [Review]
    Neuroimaging Clin N Am. 2019 Aug; 29(3):445-459.Raybaud C
  • The corpus callosum is the largest of the 3 telencephalic commissures in eutherian (placental) mammals. Although the anterior commissure, and the hippocampal commissure before being pushed dorsally by the expanding frontal lobes, cross through the lamina reuniens (upper part of the lamina terminalis), the callosal fibers need a transient interhemispheric cellular bridge to cross. This review desc…
  • Cajal-Retzius neurons are required for the development of the human hippocampal fissure. [Journal Article]
    J Anat. 2019 09; 235(3):569-589.Meyer G, González-Arnay E, … González-Gómez M
  • Cajal-Retzius neurons (CRN) are the main source of Reelin in the marginal zone of the developing neocortex and hippocampus (HC). They also express the transcription factor p73 and are complemented by later-appearing GABAergic Reelin+ interneurons. The human dorsal HC forms at gestational week 10 (GW10), when it develops a rudimentary Ammonic plate and incipient dentate migration, although the dor…
  • Histological and MRI Study of the Development of the Human Indusium Griseum. [Journal Article]
    Cereb Cortex. 2019 12 17; 29(11):4709-4724.Bobić Rasonja M, Orešković D, … Jovanov Milošević N
  • To uncover the ontogenesis of the human indusium griseum (IG), 28 post-mortem fetal human brains, 12-40 postconceptional weeks (PCW) of age, and 4 adult brains were analyzed immunohistochemically and compared with post-mortem magnetic resonance imaging (MRI) of 28 fetal brains (14-41 PCW). The morphogenesis of the IG occurred between 12 and 15 PCW, transforming the bilateral IG primordia into a r…
  • Substance P receptor in the rat indusium griseum during postnatal development. [Journal Article]
    Neurosci Res. 2018 May; 130:23-38.Barbaresi P
  • The presence of substance P (SP) receptor (Neurokinin-1 receptor, NK1R) in the indusium griseum (IG) and anterior hippocampal continuation (AHC) during postnatal development was studied by immunocytochemistry (ICC). NK1R-immunopositive neurons (NK1RIP-n) first appeared in both areas on postnatal day (P) 5. From P5 onward, their distribution pattern was adult-like. In sagittal sections NK1RIP-n fo…
  • Phylogenetic analyses place the monotypic Dryopolystichum within Lomariopsidaceae. [Journal Article]
    PhytoKeys. 2017Chen CW, Sundue M, … Huang YM
  • The monotypic fern genus Dryopolystichum Copel. combines a unique assortment of characters that obscures its relationship to other ferns. Its thin-walled sporangium with a vertical and interrupted annulus, round sorus with peltate indusium, and petiole with several vascular bundles place it in suborder Polypodiineae, but more precise placement has eluded previous authors. Here we investigate its …
  • Agenesis of the corpus callosum in Nogo receptor deficient mice. [Journal Article]
    J Comp Neurol. 2017 02 01; 525(2):291-301.Yoo SW, Motari MG, Schnaar RL
  • The corpus callosum (CC) is the largest fiber tract in the mammalian brain, linking the bilateral cerebral hemispheres. CC development depends on the proper balance of axon growth cone attractive and repellent cues leading axons to the midline and then directing them to the contralateral hemisphere. Imbalance of these cues results in CC agenesis or dysgenesis. Nogo receptors (NgR1, NgR2, and NgR3…
  • Perinatal midline astrocyte development is impaired in fibroblast growth factor 8 hypomorphic mice. [Journal Article]
    Brain Res. 2016 09 01; 1646:287-296.Stewart CE, Corella KM, … Chung WCJ
  • Our previous studies showed that Fgf8 mutations can cause Kallmann syndrome (KS), a form of congenital hypogonadotropic hypogonadism, in which patients do not undergo puberty and are infertile. Interestingly, some KS patients also have agenesis of the corpus callosum (ACC) suggesting that KS pathology is not limited to reproductive function. Here, we asked whether FGF8 dysfunction is the underlyi…
  • Functional connectivity in rat brain at 200 μm resolution. [Journal Article]
    Brain Connect. 2014 Sep; 4(7):470-80.Hyde JS, Li R
  • The somatosensory functional magnetic resonance imaging (fMRI) response to electrical stimulation of the middle phalange of the second digit of four rats at a spatial resolution of 200 μm cubic at 9.4 T is reported. At high threshold (p<0.002), activated voxels encompass a penetrating vein that passes across the gray matter. These voxels lie mostly in three contiguous slices perpendicular to the …
  • The indusium griseum and the longitudinal striae of the corpus callosum. [Review]
    Cortex. 2015 Jan; 62:34-40.Di Ieva A, Fathalla H, … Tschabitscher M
  • In the eighteenth century, Lancisi described the indusium griseum (IG) and the longitudinal striae (LS) of the corpus callosum. The IG is a thin neuronal lamina above the corpus callosum, covered on each side of the midline by the medial and lateral LS. The medial LS (nerves of Lancisi) and lateral LS are two pairs of myelinated fiber bands found in the gray matter of the IG on the dorsal aspect …
  • Classification and phylogeny of the cyanobiont Anabaena azollae Strasburger: an answered question? [Review]
    Int J Syst Evol Microbiol. 2014 Jun; 64(Pt 6):1830-40.Pereira AL, Vasconcelos V
  • The symbiosis Azolla-Anabaena azollae, with a worldwide distribution in pantropical and temperate regions, is one of the most studied, because of its potential application as a biofertilizer, especially in rice fields, but also as an animal food and in phytoremediation. The cyanobiont is a filamentous, heterocystic cyanobacterium that inhabits the foliar cavities of the pteridophyte and the indus…
  • Phylogeny and biogeography of exindusiate Andean Polystichum (Dryopteridaceae). [Journal Article]
    Am J Bot. 2014 Feb; 101(2):365-75.McHenry MA, Barrington DS
  • CONCLUSIONS: The monophyletic exindusiate Andean Polystichum lineage diverged from a Mexican lineage in the middle Miocene and diversified in the central Andes before dispersing northward. This south-to-north dispersal pattern, documented for many other Andean lineages, corresponds with episodes of uplift in the tropical Andes.
  • Heparan sulfotransferases Hs6st1 and Hs2st keep Erk in check for mouse corpus callosum development. [Journal Article]
    J Neurosci. 2014 Feb 05; 34(6):2389-401.Clegg JM, Conway CD, … Pratt T
  • The corpus callosum (CC) connects the left and right cerebral hemispheres in mammals and its development requires intercellular communication at the telencephalic midline mediated by signaling proteins. Heparan sulfate (HS) is a sulfated polysaccharide that decorates cell surface and extracellular matrix proteins and regulates the biological activity of numerous signaling proteins via sugar-prote…
  • Surgical anatomy of the hippocampus. [Journal Article]
    Neurochirurgie. 2013 Aug-Oct; 59(4-5):149-58.Destrieux C, Bourry D, Velut S
  • CONCLUSIONS: Consequences of this complex anatomy are presented, and the authors stress the need for a subpial resection. Important landmarks are provided to avoid lesions of the surrounding structures.
  • The indusium griseum: anatomic study with potential application to callosotomy. [Journal Article]
    Neurosurgery. 2013 Aug; 73(2):312-5; discussion 316.Tubbs RS, Prekupec M, … Cohen-Gadol AA
  • CONCLUSIONS: The IG is a glial membrane with no neuronal content or obvious connections to the hippocampus. Based on this study, transection of this membrane with callosotomy should not be the reason for postoperative memory loss seen in some of these patients. Future studies aimed at elucidating the function of the IG in humans are now warranted.
  • Diffusion imaging of the congenitally thickened corpus callosum. [Case Reports]
    AJNR Am J Neuroradiol. 2013 Mar; 34(3):660-5.Rollins NK
  • This report presents 4 subjects with congenital segmental callosal thickening, an uncommon malformation studied with MR imaging and DTI. Medical records were reviewed for genetic testing and neurodevelopmental status. Three subjects had profound developmental delay; 3 had seizures. MR imaging showed segmental thickening of the rostral and/or midcallosal body. Associated anomalies included polymic…
  • Multiple Slits regulate the development of midline glial populations and the corpus callosum. [Journal Article]
    Dev Biol. 2012 May 01; 365(1):36-49.Unni DK, Piper M, … Richards LJ
  • The Slit molecules are chemorepulsive ligands that regulate axon guidance at the midline of both vertebrates and invertebrates. In mammals, there are three Slit genes, but only Slit2 has been studied in any detail with regard to mammalian brain commissure formation. Here, we sought to understand the relative contributions that Slit proteins make to the formation of the largest brain commissure, t…
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