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19,539 results
  • l-DOPA and Its Receptor GPR143: Implications for Pathogenesis and Therapy in Parkinson's Disease. [Review]
    Front Pharmacol 2019; 10:1119Goshima Y, Masukawa D, … Aladeokin AC
  • l-3,4-Dihydroxyphenylalanine (l-DOPA) is the most effective therapeutic agent for Parkinson's disease (PD). l-DOPA is traditionally believed to be an inert amino acid that exerts actions and effectiveness in PD through its conversion to dopamine. In contrast to this generally accepted idea, l-DOPA is proposed to be a neurotransmitter. Recently, GPR143 (OA1), the gene product of ocular albinism 1 …
  • A narrow residence time incubation reactor for continuous virus inactivation based on packed beds. [Journal Article]
    N Biotechnol 2019Senčar J, Hammerschmidt N, … Jungbauer A
  • A narrow residence time distribution (RTD) is highly desirable for continuous processes where a strict incubation time must be ensured, such as continuous virus inactivation. A narrow RTD also results in faster startup and shut down phases and limits the broadening of potential disturbances in continuous processes. A packed bed reactor with non-porous inert beads was developed to achieve narrow R…
  • Site-selective remote C(sp3)-H heteroarylation of amides via organic photoredox catalysis. [Journal Article]
    Nat Commun 2019; 10(1):4743Chen H, Fan W, … Yu S
  • Radical translocation processes triggered by nitrogen-centered radicals (NCRs), such as 1,5-hydrogen atom transfers (1,5-HAT), demonstrated by the well-established Hofmann-Löffler-Freytag (HLF) reaction, provide an attractive approach for the controllable and selective functionalization of remote inert C(sp3)-H bonds. Here we report an amidyl radical-triggered site-selective remote C(sp3)-H heter…
  • Sorting by interfacial tension (SIFT): Label-free enzyme sorting using droplet microfluidics. [Journal Article]
    Anal Chim Acta 2019; 1089:108-114Horvath DG, Braza S, … Abbyad P
  • Droplet microfluidics has the ability to greatly increase the throughput of screening and sorting of enzymes by carrying reagents in picoliter droplets flowing in inert oils. It was found with the use of a specific surfactant, the interfacial tension of droplets can be very sensitive to droplet pH. This enables the sorting of droplets of different pH when confined droplets encounter a microfabric…
  • Use of Acellular Dermal Matrix to Prevent Recurrence of Radioulnar Heterotopic Ossification. [Case Reports]
    Plast Reconstr Surg Glob Open 2019; 7(6):e2257Gould DJ, Rahgozar P, … Kulber DA
  • Radioulnar heterotopic ossification is a rare occurrence found in approximately 2% of all forearm injuries. Treatment is complicated by relatively high recurrence rates. Strategies to decrease recurrence have included the range of motion exercises and the interposition of inert or autogenous barriers. We report on the interposition of human acellular dermal matrix (ADM) for the treatment of dista…
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